Oxytocin e fetola litšenyehelo tse bakoang ke amphetamine ho hokahanngoa ha sechaba: bopaki ba ho sebelisana le nucleus accumbens dopamine (2014)

Ho lemalla lithethefatsi ho na le litlamorao tse bohloko litloaelanong tsa sechaba ebile ho ka lebisa ho senyeheng ha tlamo ea botsoalle. Bopaki bo felletseng bo bonts'a hore liphetoho tse bang teng lipakeng tsa oxytocin (OT) le dopamine (DA) neurotransmission ka har'a "portal" ea moputso oa boko.

Re fuputse monyetla ona, le menyetla ea kalafo ea OT bakeng la bofokoli ba tšebeliso ea lithethefatsi sechabeng, re sebelisa prairie vole (Microtus ochrogaster) - setlokotsebe se atamelaneng sechabeng se thehang maqhama a pakeng tsa balekane ba baholo. Re bontša hore ho pepesehela khafetsa psychostimulant amphetamine (AMPH) khafetsa ho thibela ho khethoa ha lithahasello tsa molekane (index ea li-bonding) ka li-voes tsa basali tsa prairie. Phatlalatso ea AMPH e boetse e fetotse li-neurotransication tsa OT le DA libakeng tse arabelang sebopeho sa khetho ea balekane: e fokotse ts'ebetso ea OT le DA D2 receptor immunoreactivity ho medial prefrontal cortex (mPFC) le li-nucleus accumbens (NAcc), ka ho latellana, le litekanyetso tsa NAcc DA tse eketsehileng.

Tsamaiso ea OT ka kotloloho ho mPFC ea li-vops tse senotsoeng tsa AMPH e khutlisetse lithahasello tsa molekane, mme e fetotsoe maemo a NAcc DA, mme phello ena e ne e itšetleha ka ts'ebetso ea li-receptor tsa OT. Ka bobeli, tlhaiso-leseling ena e fana ka maikutlo a hore ho pepeseha hoa ts'ebetso ea AMPH ho senyeha ka mokhoa o kopanetsoeng ke OT, le hore litsamaiso tsa OT le DA tse tsamaisong ea moputso oa boko li ka sebelisana ho rarolla kamano e rarahaneng lipakeng tsa tlhekefetso ea lithethefatsi le tlamahano ea sechaba. Ho feta moo, liphetho tsena li fana ka tšehetso e matla bakeng sa mohopolo oa hore Sisteme ea OT e ka emela sepheo sa bohlokoa kalafong ea bofokoli ba sechaba ka ho lemalla.

• PMID:
• 24948805
• [E hatisitsoe - e na le index ea MEDLINE]