Jokinen, Jussi
Univesithi ea Umeå, Setsi sa Bongaka, Lefapha la Mahlale a Clinical.ORCID iD: 0000-0001-6766-7983
Flanagan, John
Chatzittofis, Andreas
Univesithi ea Umeå, Setsi sa Bongaka, Lefapha la Saense ea Tleliniki.
Oberg, Katarina
Abstract [en]
Ka morao: Boloetse ba Hypersexual (HD) bo kopanyang likarolo tsa lefu la ts'oaetso joalo ka tlolo ea takatso ea thobalano, bokhoba ba thobalano, ho qobelloa le ho qobelloa ho khothaletsoa e le tlhahlobo ea DSM-5. "Compulsive Sexual Behaeve Disorder" joale e hlahisoa e le boloetse ba khatello ea maikutlo ho ICD-11. Liphuputso tsa morao-rao li bontšitse axis ea HPA axis ho banna ba nang le HD. Oxytocin (OXT) e ama tšebetso ea selekane sa HPA; ha ho lithuto tse hlahlobileng maemo a OXT ho bakuli ba nang le HD. Hore na kalafo ea CBT ea matšoao a HD e na le phello maemong a OXT ha e so batlisisoe.
Mekhoa: Re hlahlobe maemo a plasma OXT ho bakuli ba banna ba nang le HD le baithaopi ba lilemo li 64 ba batona ba phetseng hantle. Ntle le moo, re ile ra hlahloba kamano lipakeng tsa boemo ba plasma OXT le matšoao a HD a sebelisang litekanyo tsa litekanyo tsa hypersexual boitšoaro: Hypersexual disorder screening inventory (HDSI) le tekanyo ea thobalano le thobalano ea thobalano (SCS). Karolo ea bakuli (N = 38) e phethile lenaneo la CBT le tsamaisitsoeng ke sehlopha la HD mme o bile le tekanyo ea bobeli ea OXT kamora kalafo. OXT e ne e lekantsoe le Radioimmunoassay (RIA).
Liphetho: Bakuli ba nang le HD ba ne ba na le maemo a phahameng haholo a OXT (Maemo a 31.0 ± SD 9.9 pM) ha a bapisoa le baithaopi ba phetseng hantle (Bolela 16.9 ± SD 3.9 pM) (p <0.001). Ho ne ho e-na le likamano tse ntle lipakeng tsa maemo a OXT le litekanyo tsa litekanyetso tse lekanyang boitšoaro ba bosodoma (Spearman rhos lipakeng tsa HDSI r = 0.649, p <0.001 le SCS r = 0.629, p <0.001) ho barupeluoa ba ithutoang ba kopane. Bakuli ba phethileng kalafo ea CBT ba bile le phokotso e kholo ea maemo a OXT ho tloha kalafong ea pele (30.5 ± 10.1pM) ho isa kalafong ea kalafo (20.2 ± 8.0pM) (p <0.001). Bakuli ba nang le HD ba bile le kamano e ntle ea liphetoho tsa bona ho HD: CAS e nang le plasma oxytocin level pele le kamora 'CBT (r = 0.388, p value = 0.0344).
Liphetho: Liphetho li bontša sistimi e matla ea oxytonergic ho bakuli ba banna ba nang le khatello ea maikutlo e ka bang mochini o tlatselletsang ho fihlela khatello ea methapo ea mali. Phekolo ea sehlopha sa CBT e atlehileng e ka ba le phello tsamaisong ea hyperactive oxytonergic.
Sebaka, mohatisi, selemo, khatiso, maqephe
Sehlopha sa Phatlalatso ea Tlhaho, 2019 Vol. 44, leq. 114-114
Mantsoe a bohlokoa [en]
Oxytocin le ho lemalla, Hypersexual Disorder, Cognitive Behahlangu Therapy
Sehlopha sa Sechaba
Pharmacology and Toxicology Neuroscience Psychiatry
Matšoao
URN: urn: nbn: se: umu: diva-168967ISI: 000509665600228OAI: oai: DiVA.org: umu-168967DiVA, id: diva2: 1420877
Seboka
Seboka sa 58 sa selemo le selemo sa American-College-of-Neuropsychopharmacology (ACNP), DEC 08-11, 2019, Orlando, FL
Tlatsetso: 1
Kopano ea Kopano: M71
E fumaneha ho: 2020-04-01 E thehiloe: 2020-04-01 E ntlafalitsoe ka ho qetela: 2020-04-01
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