Ha e le hantle - boikoetliso bo eketsa maemo a mantlha a dopamine. Bokhoba ba lithethefatsi bo fokotsa dopamine. Kahoo boikoetliso bo botle haholo.
Neuromolecular Med. 2008; 10 (2): 67-80. doi: 10.1007 / s12017-008-8032-3. Epub 2008 Feb 15.
mohloli o moholo
Setsi sa Ntlafatso ea 'Mele sa Lefapha, Setsi sa Neuroscience, Moaho o Monyenyane oa Clare, Univesithi ea Colado-Boulder, Boulder, CO 80309-0354, USA.
inahaneloang
Ho ikoetlisa ho eketsa tšebetso ea methapo tsamaisong e fapaneng ea li-neurotransmitter. Tlhahlobo ea hajoale e shebisisa litlamorao tsa ho ikoetlisa ka tloaelo ho li-neurotransication tsa DAamine le moelelo o ka bang teng oa liphetoho tsena molemong oa ho tepella maikutlo.
Le ha ho hlakile hore ts'ebeliso ea pheripherse ts'ebelisong ea mesifa le matla a substrate e kenya letsoho ho sena, haufinyane tjena ho 'nile ha fanoa ka maikutlo a hore methapo ea methapo e "nyolohelang" ea motor cortex, e qalang ts'ebetso ea mesifa ea masapo, le eona e bohlokoa. Monehelo oa boko mokhathaleng o bakoang ke ho ikoetlisa o 'nile oa bitsoa “mokhathala o bohareng.”Ha ho fanoa ka karolo e hlalositsoeng hantle ea DA ts'ebetsong ea motsamao, ho kanna ha etsahala hore liphetoho mekhoeng ea DA li susumetsa boikoetliso.
Phokotso ea tšebetso ea methapo ea methapo ea DA ho substantia nigra pars compacta (SNpc), mohlala, e ka fokolisa ts'ebetso ea gangal ea basal le ho fokotsa ho ts'oaroa ha motor cortex e lebisang mokhathala o bohareng.
Mona re hlahisa bopaki ba hore tloaelo ea ho tsamaea ka mabili e hlahisa liphetoho lits'ebetsong tsa DA. Re sebelisa mekhoa ea hybridization ea rona, re tlaleha hore libeke tsa 6 tsa ho tsamaea ha mabili li ne li lekane ho eketsa polelo ea tyrosine hydroxylase mRNA le ho fokotsa D2 autoreceptor mRNA ho SNpc. Ho feta moo, libeke tsa 6 tsa ho tsamaea ka mabili li eketsehile D2 postsynaptic receptor mRNA ho caudate putamen, sebaka se seholo sa projeke ea SNpc.
Liphetho tsena li tsamaisana le tlhaiso-leseling e fanang ka maikutlo a hore liphoofolo tse tloaetseng ho phela ka 'mele li ka ba le bokhoni bo ntlafalitsoeng ba ho eketsa sebopeho sa DA le ho fokotsa D2 autoreceptor-mediated inhibition ea li-neurons tsa DA ho SNpc ha li bapisoa le liphoofolo tse lulang li lutse fatše.
Furthermore, liphoofolo tse tloaetseng ho phela hantle 'meleng, ha li bapisoa le taolo ea ho lula fatše, li ka khona ho ntlafatsa litšitiso tsa D2 receptor-mediated tse tseleng e sa tobang ea gangal. Liphetho tsa lithuto tsena li tšohloa ka leseli la kutloisiso ea rona ea karolo ea DA lits'ebetsong tsa methapo ea kutlo ea mokhathala o bohareng.
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