ពេទ្យចិត្តសាស្ត្រ (Berl) ។ 2004 Dec;177(1-2):121-9.
van de Laar MC1, Licht R, Franken IH, Hendriks VM ។.
អរូបី
លំដាប់:
Motivational drive and its underlying affect-related states are the core mechanisms that precede the seeking and taking of drugs in substance dependence.
គោលបំណង:
The present study aimed to investigate the motivational relevance of cocaine cues and whether or not an appetitive emotional system is involved employing event-related potential (ERP) measurements.
វិធីសាស្រ្ត:
Cocaine-addicted subjects and healthy controls were exposed to neutral and cocaine-related pictures whilst ERPs were recorded simultaneously over frontal, parietal and midline sites.
លទ្ធផល:
Patients exhibited ERP amplitude discrepancies between neutral and cocaine-related pictures for N300, late slow positive wave (LSPW) and sustained slow positive wave (SSPW), whilst this effect was absent in control subjects. Differences in neutral and cocaine cue-evoked ERP waves were also found at left frontal sites for LSPW and SSPW in the patient group only. No group-specific cue-evoked ERP amplitudes were observed at parietal and midline sites.
សេចក្តីសន្និដ្ឋាន:
The findings confirm the assumption that cocaine cues induce motivational relevance in cocaine-dependent individuals. It is possible that exposure to cocaine cues triggers an appetitive emotional system since left frontal sites are assumed to be involved in processing positive emotional-laden stimuli. The present study provides evidence that the sensitivity of ERP correlates for cocaine cues may be an indicator of motivational and emotional processes in drug-dependent individuals.
- PMID:
- 15221199
- [PubMed - បានធ្វើលិបិក្រមសម្រាប់ MEDLINE]