J Neurol Sci. 2011 Nov 15; 310 (1-2): 53-7. Epub 2011 Jul 23.
Moriyama TS, Felicio AC, Chagas MH, Tardelli VS, Ferraz HB, Tumas V, Amaro-Junior E, Andrade LA, Crippa JA, Bressan RA.
Šaltinis
Instituto do Cérebro, Instituto de Ensino e Pesquisa do ligoninė Israelita Albert Einstein, San Paulas, Brazilija. [apsaugotas el. paštu]
Abstraktus
Social Anxiety Disorder (SAD) is more common among PD patients than in the general population. This association may be explained by psychosocial mechanisms but it is also possible that neurobiological mechanism underlying PD can predispose to SAD.
Šio tyrimo tikslas buvo ištirti galimą dopaminerginį mechanizmą, susijusį su PD sergančių pacientų, sergančių PDD, poveikiu, koreliuojant striatrijos dopamino transporterio surišimo potencialą (DAT-BP) su PD pacientų socialinio nerimo simptomų intensyvumu. using SPECT with TRODAT-1 as the radiopharmaceutical. Eleven PD patients with generalized SAD and 21 PD patients without SAD were included in this study; groups were matched for age, gender, disease duration and disease severity. SAD diagnosis was determined according to DSM IV criteria assessed with SCID-I and social anxiety symptom severity with the Brief Social Phobia Scale (BSPS). Demographic and clinical data were also collected.
DAT-BP was significantly correlated to scores on BSPS for right putamen (r=0.37, p=0.04), left putamen (r=0.43, p=0.02) and left caudate (r=0.39, p=0.03). No significant correlation was found for the right caudate (r=0.23, p=0.21). Šis atradimas gali sustiprinti hipotezę, kad dopaminerginė disfunkcija gali būti susijusi su socialinio nerimo patogeneze PD.
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