Iingxelo: Uphando olutsha lwe-Italia lufumanisa ukuba i-25% yezigulane ezintsha ezinzima i-erectile dysfunction iphantsi kwe-40.
IMITHETHO: Uhlalutyo lohlolisiso lubonise ukuba esinye sezigulane ezine ezifuna uncedo lokuqala lwezonyango kwi-ED entsha sasiyincinane kune-40 iminyaka. Phantse isiqingatha sabaselula abahluphekileyo kwi-ED, kunye neerhafu ezifananisiweyo kwizigulane ezigugile. Ngokubanzi, amadoda amancinane ahluke kumntu omdala ngokwemimiselo yeeklinikhi kunye neentlalo.
J Sex Med. 2013 Jul;10(7):1833-41. i-doi: 10.1111 / jsm.12179.
Capogrosso P, Colicchia M, Ventimiglia E, Castagna G, Clementi MC, Suardi N, Castiglione F, Briganti A, Cantiello F, Damiano R, Montorsi F, Salonia A.
imvelaphi
Isebe le-Urology, i-University Vita-Salute uSan Raffaele, eMilan, eItali.
Abstract
INTSHAYELELO:
I-Erectile i-dysfunction (ED) isikhalazo esiqhelekileyo kumadoda ngaphezu kweminyaka eyi-40 ubudala, kwaye ukukhula kwamazinga okunyuka kunyuke ngexesha lokuguga. Ubunzima kunye nemingcipheko ye-ED phakathi kwamadoda amancinci ahlalutyiwe ngokukhawuleza.
AIM:
Ukuvavanya iimeko zentlalo kunye neempawu zekliniki zamadoda amancinci (achazwe njenge ≤ iminyaka eyi-40) efuna uncedo lokuqala lwezonyango kwi-ED entsha njengengxaki yabo yesondo.
IINDLELA:
Ukuzalisa i-sociodemographic kunye nedatha yeklinikhi evela kwizigulane ezilandelanayo ze-439 zahlaziywa. Iimpawu ezingabalulekanga zempilo zifunyenwe kunye neCharlson Comorbidity Index (CCI). Izigulityi zigqityiwe i-International Index ye-Erectile Function (IIEF).
IMISEBENZI YOKUPHATHWA KWEENKQUBO:
Iinkcukacha-manani ezichazayo zavavanya imeko yezentlalo kunye nokwahluka kweklinikhi phakathi kwezigulana ze-ED ukuya kwiminyaka engama-40 kunye> neminyaka engama-40.
IINKCUKACHA:
Ukuqala okutsha kwe-ED njengengxaki eyimfuneko efunyenwe kwi-114 (26%) amadoda ≤ iminyaka eyi-40 (ithetha ukuguquka okuqhelekileyo [SD]]: 32.4 [6.0]; ibanga: 17-40 iminyaka). Izigulana years iminyaka engama-40 inezinga eliphantsi leemeko comorbid (CCI = 0 kwi-90.4% vs 58.3%; χ (2), 39.12; P <0.001), ixabiso elisezantsi lomzimba elinexabiso lesalathiso somzimba (P = 0.005), kunye Intsingiselo ephezulu yokujikeleza kwenqanaba le testosterone (P = 0.005) xa kuthelekiswa nezo> zeminyaka engama-40. Izigulana ezincinci ze-ED zihlala zibonisa umkhwa wokutshaya icuba kunye nokusetyenziswa kweziyobisi ezingekho mthethweni, xa kuthelekiswa namadoda amadala (yonke iP ≤ 0.02). I-ejaculation yangaphambi kwexesha yayiyinto ehlekisayo kumadoda amancinci, ngelixa isifo sikaPeyronie sasixhaphakile kwiqela elidala (yonke i-P = 0.03). I-IIEF, iirhafu ezinzima ze-ED zafunyanwa kwi-48.8% yamadoda amancinci kunye ne-40% yamadoda amadala, ngokwahlukeneyo (P> 0.05). Kwangokunjalo, amaqondo obumnene, ophakathi nokumodareyitha, kunye ne-ED engafaniyo ayengafani ngokwahlukileyo phakathi kwala maqela mabini.
IMISEBENZI:
Uhlalutyo lohlolisiso lubonise ukuba esinye sezigulane ezine ezifuna uncedo lokuqala lwezonyango kwi-ED entsha sasiyincinane kune-40 iminyaka. AIsiqingatha sabaselula abahluphekileyo kwi-ED, kunye namazinga athathekayo kwizigulane ezigugile. Ngokubanzi, amadoda amancinane ahluke kumntu omdala ngokwemimiselo yeeklinikhi kunye neentlalo.
© 2013 International International for Medical Medicine.
IINKCUKACHA:
Ubudala, Ukukhubazeka Kwezonyango, Ukukhuseleka, Ukuguga, Ukukhubazeka kwe-Erectile, Isimo sezeMpilo, iNkcazo yeSizwe ye-Erectile Function, Izinto ezinobungozi, abancinci
PMID: 23651423
intshayelelo
I-Erectile i-dysfunction (ED) isikhalazo esiqhelekileyo kumadoda ngaphezu kweminyaka eyi-40 ubudala, kwaye ukunyuka kwamazinga kwanda ngexesha lokuguga [1].
Ininzi yemibhalo yesandla echaphazelekayo kwi-ED ivame ukuvula ngolu hlobo, kungakhathaliseki ukuba ingqalelo nawuphi na uluntu okanye uhlanga,
kwanoma yiphina inzululwazi isifundo / umphandi ungowabo, kwaye nayiphi na iphephandaba lezesayensi apho imibhalo yesandla ipapashwe. Ngamanye amagama, abadala bafumana, xa beqala ukujongana no-ED [2].
Ngokudibeneyo, i-ED ngokuthe ngcembe ifumene indima ebalulekileyo njengesipili sempilo yamadoda iyonke, ithatha ukubaluleka kokusebenza kwentliziyo
Kwintsimi [3-6]. Ke ngoko, kuqinisekile ukuba i-ED ifikelele ekubalulekeni okubonakalayo hayi kuphela kwicandelo lezonyango, kodwa nakwicandelo lezempilo loluntu, ngenxa yefuthe lazo kwezentlalo zobomi bomntu. Inzala ekhulayo yesi sihloko ikhokelele kuphuhliso lwezinto ezininzi
Uphando malunga nokuxhaphaka kunye nemingcipheko ye-ED phakathi kweefomathi ezahlukeneyo zezigulane [7, 8]; kulo mongo, inkoliso yeenkcukacha ezipapashwe zibhekisela kubantu abaneminyaka ephakathi kunye nabalupheleyo besilisa, kwaye ngokukodwa kubantu abangaphezu kweminyaka eyi-40 ubudala [7-9]. Ngokuqinisekileyo, amadoda asebegugile, kwaye ngokuqinisekileyo asebekhulile, bahlala bexhamla kwiimeko ezinzima-ezifana nesifo sikashukela, ukukhuluphala, izifo ze-cardiovascular disease (CVD), kunye neempawu ze-urinary (I-LUTS) ezisezantsi ezinokuthi zilungele ukulungiswa kwe-ED [7-12].
Ngakolunye uhlangothi, iziganeko zentsholongwane kunye nobungozi be-ED phakathi kwamadoda amancinci ziye zahlaziywa ngokukhawuleza. Idatha kule ngqutyana yamadoda ibonisa amazinga e-ED aphakathi kwe-2% kunye no-40% kubantu abangaphantsi kweminyaka eyi-40 ubudala [13-16]. Ngokubanzi, idatha edityanisiweyo igxininise ukubaluleka kwe-ED kumadoda amancinci, nangona le nxalenye ethile yabantu abazange ibonakale ikwabelana ngemingcipheko efanayo yonyango yamadoda amadala akhononda ngokukhubazeka komsebenzi we-erectile [15, 16], oko kukhokelela ekukholweni ukuba iqela leengqondo lixhaphake kakhulu kwizigulane ezincinci ezineengxaki zokulungiswa okanye ukuxinzezeleka kwezinto ezichaphazelekayo [17].
Ngokubanzi, phantse zonke iingxelo zixela ukubaluleka kwe-ED ngokumalunga noluntu jikelele, kwaye ngale ndlela akukho nxu lumene nedatha
kwindlela yokwelapha yemihla ngemihla; Ngokufanayo, akukho datha ifumaneka ngokucacileyo malunga nezo zigulane ezincinci ezifuna uncedo lwezokwelapha kwimeko yeklinikhi ngenxaki ehambelana nomgangatho wokwakhiwa kwawo. Ngalolu hlobo, safuna ukuvavanya ubungakanani kunye nokuqikelela kwe-ED kumadoda amancinci (ngokucacileyo achazwa ≤40 ubudala ubudala) njengengxenye yeqela elilandelelanayo laseCaucasian-European ukufuna uncedo lokuqala lwezonyango zokungasebenzi kakubi ngokwesondo kwiziko elilodwa lezemfundo.
tindlela
Lwabantu
Uhlalutyo lwalusekelwe kwiqela le-790 ezilandelelanayo zaseCaucasian-European ezithintekayo izigulana ezifuna ukufumana unyango lokuqala lokusasazeka ngokwesondo phakathi kukaJanuwari 2010 kunye noJuni 2012 kwiklinikhi eyodwa yezikolo eziphambili. Ngenjongo ethile yale sifundo yophando, kuphela idatha evela kwizigulana ezikhalazayo nge-ED zacatshangelwa. Kule njongo, i-ED yachazwa njengengenakukwazi ukufezekisa okanye ukugcina ukulungelelaniswa okwaneleyo ekusebenzeni ngokwesondo [18].
Izigulane zavavanywa ngokugqithisileyo kunye nembali yecandelo lezokwelapha kunye nezesondo, kubandakanywa nedatha yoluntu. Iimpawu ezinobungozi zempilo zafakwa kunye neCharlson Comorbidity Index (CCI) [19] zombini njengoluhlu oluqhubekayo okanye oludidiyelwe (okt, 0 vs 1 vs ≥2). Sasisebenzisa Ulwahlulo lwaMazwe ngamazwe, Ukuhlaziywa kwe-9th, ukuguqulwa kwezonyango. I-index ye-mass body index (BMI),
ichazwa njengesisindo kwiikhilogram ngokuphakama kwiimitha ezi-square, yaqwalaselwa isigulane ngasinye. Kwi-BMI, sasebenzisa i-cutoffs ecetywayo
amaZiko eNational Health [20]: ubunzima obuqhelekileyo (18.5-24.9), ukutyeba kakhulu (25.0-29.9), kunye nodidi ≥1 ukutyeba kakhulu (-30.0). Uxinzelelo lwexinzelelo lwegazi lwachazwa xa amayeza athatha uxinzelelo lwegazi athathwe kunye / okanye uxinzelelo lwegazi oluphezulu (≥140 mm Hg systolic okanye ≥90 mm Hg diastolic). I-Hypercholesterolemia yachazwa xa unyango lwe-lipid-lowing luthathiweyo kunye / okanye i-cholesterol ephezulu ye-lipoprotein cholesterol (HDL) yayiyi- 40 mg / dL. Ngokufanayo, i-hypertriglyceridemia yachazwa xa i-plasma triglycerides yayingu-150 mg / dL [21]. Iprogram yeSizwe yeCholesterol yeNkqubo-I-Panel Treatment Panel III [21] Iimpawu zenziwa ngokuphindaphindiweyo ukuchaza ukuxhaphaka kwe-syndrome (MeTs) kwiqela elipheleleyo lamadoda ane-ED.
Ukulungiselela injongo ethile yolu phononongo kunye nokubonisa isenzo esiqhelekileyo selabhoratri yeekhemikhali, sonyule ukulinganisa ukujikeleza amanqanaba e testosterone (tT) ngokusebenzisa iindlela zohlalutyo ezikhoyo. I-Hypogonadism ichazwe njenge-tT <3 ng / mL [22].
Izigulane zaza zahlanjululwa ngokobuhlobo babo bobudlelwane (ezichazwe ngokuthi "ubudlelwane obulilileyo ngokwesondo" ukuba izigulane zazinomlingani ofanayo
kwiinyanga ezintandathu okanye ngaphezulu ezilandelelanayo; ngenye indlela "akukho buhlobo obuzinzile" okanye umhlolokazi). Ngokufanayo, izigulane zahlukaniswa ngokwemiqathango yazo yezemfundo kwiqela eliphantsi lemfundo (oko kukuthi, imfundo yesikolo esisekondari kunye nesesekondari), iqela lezinga eliphakamileyo lemfundo, kunye namadoda anezinga eliphezulu lemfundo (oko kukuthi, i-degree yunivesithi / i-postgraduate degree).
Ngaphezu koko, izigulane zacelwa ukuba zizalise i-International Index ye-Erectile Function (IIEF) [23]; ukubonelela isakhelo sesithenkethi ngokuchanekileyo ukutolika ubunzima be-ED, sasebenzise udidi lwe-IIEF-erectile domain domain njengoko kucetyiswa nguCapelleri et al. [24].
Ingxaki zokufunda nokubhala kunye nezinye iingxaki zokufunda nokubhala zazingabandakanywa kuzo zonke izigulane.
Iqoqo leenkcukacha lwenziwa emva kwemigaqo echazwe kwiSibhengezo saseHelsinki; zonke izigulane zisayine imvume enolwazi evuma ukuhambisa ulwazi lwazo olungabonakaliyo ngezifundo ezizayo.
Iziphumo eziPhambili
Isiphumo esiphambili sophando lwangoku kwakuhlolisisa ukuxhaphaka kunye nokuqikelelwa kokuqala kwe-ED kumadoda amancinci afuna uncedo lwabo lokuqala lwezonyango
kwisimo seklinikhi yansuku zonke, ngokubhekiselele ekutshitshweni kwe-40 kweminyaka yobudala. Isicwangciso sokugqibela sesibini ukuhlola ukuba isenzo sokusebenza ngokwesini, njengoko sineenkalo ezahlukeneyo ze-IIEF, safumana ngokwahlukileyo kumadoda omncinci kuneminyaka eyi-40 ubudala xa kuthelekiswa nezigulane ezigugile.
Uhlalutyo lweSatisati
Ukulungiselela injongo ethile yolu hlalutyo, abaguli abanesifo esitsha se-ED kwaye bafuna uncedo lokuqala kwezonyango ngokulandelelana kwabo baba ngamadoda ≤ iminyaka eyi-40 kunye nabantu> iminyaka eyi-40. Inkcazo echazayo isetyenzisiwe ukuthelekisa iklinikhi kunye neempawu zentlalo yabantu
maqela a mabini. Iinkcukacha zenziwe njengentsingiselo (ukuphambuka okuqhelekileyo [SD]). Ukubaluleka kwenani leentlukwano kwindlela kunye nokulinganisa
vavanywa ngee-tailed ezimbini t-vavanyo kunye ne-chi-square (χ2) iimvavanyo, ngokulandelanayo. Uhlalutyo lwesitatisti lwenziwe ngokusebenzisa i-13.0 (IBM Corp., Armonk, NY, USA). Zonke iimvavanyo zazinzibini zecala, kunye nenqanaba elibalulekileyo elibekwe kwi-0.05.
iziphumo
Ukuqala okutsha kwe-ED njengengxaki ephambili yafunyanwa kwizigulana ezingama-439 (55.6%) kwizigulana ezingama-790. Kubo, i-114 (25.9%) yayineminyaka engama-old40 ubudala. Itheyibhile 1 iimpawu zeenkcukacha zabantu kunye neenkcukacha ezichazayo zeqela elipheleleyo lezigulane ezine-ED, njengoko zihlukaniswe ngokweminyaka yobudala be-40. Kulo mongo, izigulane ≤40 ubudala ubudala ngexesha lokuqala kwabo befuna unyango lwe-ED lubonise
Ixabiso elincinci leemeko ze-comorbid (njengengqinisiso efunyenwe kunye neCCI), inani elincinci le-BMI, inani elincinane labantu abane-BMI ebonisa ukugqithisa kakhulu kunye neklasi ≥I-1 ukukhuluphala, izinga elingaphantsi lomfutho wexinzelelo kunye ne-hypercholesterolemia, kunye nenqanaba elingaphantsi elijikelezayo leTT xa kuthelekiswa nalabo badala kuneminyaka eyi-40 (konke P ≤ 0.02). Kwelinye icala, akukho mahluko waqwalaselwayo phakathi kwamaqela ngokwexabiso le-hypertriglyceridemia, MetS, kunye ne-hypogonadism (Itheyibhile 1). Ngaphezu koko, izigulane ze-ED ezincinane zabonisa izinga eliphezulu lokwabelana ngesini ngokwesini kunye nesahlulo esincinci sobudlelwane bezesondo obuzinzile (konke P ≤ 0.02). Akukho mahluko ubalulekileyo waqwalaselwa ngokwemeko yemfundo phakathi kwamaqela. Iqondo eliphezulu kakhulu le-comorbid ejaculation ngaphambi kwexesha (nokuba kukuphila okanye kufunyenwe) kwajongwa kwizigulana ezincinci kunakwabantu abadala; ngokuchaseneyo, isifo sikaPeyronie sasikhona kwiqela elidala (konke P = 0.03), ngelixa kwakungekho nantlukwano kubukho besifiso esiphantsi sesini phakathi kwala maqela mabini (Itheyibhile 1).
| Izigulane ≤40 iminyaka | Izigulana> iminyaka engama-40 | P inani* | |
|---|---|---|---|
| |||
| Inombolo yezigulane (%) | 114 (25.9) | 325 (74.1) | |
| Ubudala (iminyaka; uthetha [SD]) | 32.4 (6.0) | 57.1 (9.7) | |
| uluhlu | 17-40 | 41-77 | |
| I-CCI (ayikho [%]) | <0.001 (χ2, 39.12) | ||
| 0 | 103 (90.4) | 189 (58.3) | |
| 1 | 6 (5.3) | 62 (19) | |
| 2+ | 5 (4.4) | 74 (22.7) | |
| BMI (kg / m2; kuthetha [SD]) | 25.1 (4.1) | 26.4 (3.7) | 0.005 |
| I-BMI (udidi lwe-NIH) (ayikho [%]) | 0.002 (χ2, 15.20) | ||
| 1 (0.9) | 0 (0) | ||
| 18.5-24.9 | 63 (56.5) | 126 (38.7) | |
| 25-29.9 | 34 (29.6) | 157 (48.3) | |
| ≥30 | 16 (13) | 42 (13) | |
| Uxinzelelo lwengqondo (No. [%]) | 6 (5.3) | 122 (37.5) | <0.001 (χ2, 42.40) |
| I-Hypercholesterolemia (No. [%]) | 4 (3.5) | 38 (11.7) | 0.02 (χ2, 5.64) |
| I-Hypertriglyceridemia (No. [%]) | 0 (0.0) | 10 (3.1) | 0.12 (χ2, 2.37) |
| I-MeTs (No. [%]) | 2 (1.8) | 10 (3.1) | 0.57 (χ2, 0.74) |
| tT (ng / mL; uthetha [SD]) | 5.3 (2.0) | 4.5 (1.8) | 0.005 |
| Hypogonadism (iyonke <3 ng / mL) (Hayi [%]) | 12 (10.3) | 54 (16.6) | 0.14 (χ2, 2.16) |
| Ukuqhelaniswa ngokwesondo (No. [%]) | 0.02 (χ2, 5.66) | ||
| Heterosexual | 109 (95.6) | 322 (99.1) | |
| Ngqingili | 5 (4.4) | 3 (0.9) | |
| Ubume bobudlelwane (uNombolo [%]) | <0.001 (χ2, 27.51) | ||
| Ulwalamano oluzinzileyo ngokwesini ≥IXXXX | 81 (71.4) | 303 (93.2) | |
| Akukho nxu lumano lwezesondo | 33 (28.6) | 22 (6.8) | |
| Isimo sezemfundo (No. [%]) | 0.05 (χ2, 9.30) | ||
| Isikolo sezinto | 0 (0) | 22 (6.8) | |
| Kumabanga aphakathi | 20 (17.5) | 64 (19.7) | |
| Isikolo esiphakamileyo | 51 (44.7) | 141 (43.4) | |
| Idigri yaseyunivesithi | 43 (37.7) | 98 (30.2) | |
| Izikhalazo zoxhatshazo zesini (No. [%]) | |||
| PE | 14 (12.4) | 20 (6.2) | 0.03 (χ2, 4.55) |
| Libido ephantsi | 10 (8.8) | 23 (7.1) | 0.55 (χ2, 0.35) |
| Isifo se Peyronie | 5 (4.4) | 37 (11.4) | 0.03 (χ2, 4.78) |
itafile 2 Uluhlu lweziyobisi ezithathwe zizigulana zala maqela mabini, zahlulwe lusapho lweziyobisi. Ngokufanayo, iTafile 2 Kwakhona iinkcukacha zokuzonwabisa ezichazwe zizigulane kwaye
lahlulwe liqela leminyaka. Izigulane ze-ED ezikhulile zazihlala zithatha
imishanguzo emininzi yentsapho nganye kunye ne-thiazide
i-diuretics kunye ne-lipid-ukwehlisa iziyobisi xa kuthelekiswa namadoda ≤40 iminyaka (konke P
≤ 0.02). Ngokufanayo, izigulane ezithe zahlala zihlala zihlala zithatha
ama-antidiabetics kunye nezidakamizwa zezilwanyana, ii-alpha-blockers ze-LUTS, kunye neproton
i-pump inhibitors kuthelekiswa namadoda amancinci (konke P ≤ 0.03).
| Izigulane ≤40 iminyaka | Izigulana> iminyaka engama-40 | P inani* | |
|---|---|---|---|
| |||
| Inombolo yezigulane (%) | 114 (25.9) | 325 (74.1) | |
| Machiza a | |||
| ACE-i | 1 (0.9) | 47 (14.5) | <0.001 (χ2, 14.62) |
| Abadlali be-Angiotensin-II | 2 (1.8) | 41 (12.6) | 0.002 (χ2, 9.95) |
| Beta-1 blockers | 2 (1.8) | 44 (13.5) | 0.0009 (χ2, 11.12) |
| Abadlali beCalcium | 0 (0.0) | 39 (12.0) | 0.002 (χ2, 13.57) |
| Diuretics | |||
| Loop diuretics | 0 (0.0) | 6 (1.8) | 0.33 (χ2, 0.94) |
| Thiazide diuretics | 0 (0.0) | 18 (5.5) | 0.02 (χ2, 5.20) |
| Ezinye iziyobisi zentliziyo | |||
| Digoxin | 0 (0.0) | 7 (2.2) | 0.24 (χ2, 1.36) |
| Izidakamizwa ze-Antiarrhymic | 1 (0.9) | 6 (1.8) | 0.82 (χ2, 0.05) |
| Iziyobisi zeAnticoagulant | 1 (0.9) | 10 (3.1) | 0.35 (χ2, 0.89) |
| Iziyobisi zeAntilatelate | 1 (0.9) | 1 (1.8) | 0.82 (χ2, 0.06) |
| Iziyobisi ezinciphisa i-Lipid (i-statins kunye / okanye i-fibrate) | 0 (0.0) | 43 (13.2) | 0.0001 (χ2, 15.21) |
| Inkqubo ye-nervous drug | |||
| Izidakamizwa zeAnticonbulsant | 1 (0.9) | 6 (1.8) | 0.82 (χ2, 0.05) |
| Barbiturates | 0 (0.0) | 2 (0.6) | 0.99 (χ2, 0.00) |
| Benzodiazepine | 2 (1.8) | 15 (4.6) | 0.29 (χ2, 1.11) |
| Neuroleptics | 2 (1.8) | 3 (0.9) | 0.79 (χ2, 0.07) |
| Iziyobisi zeOpioid | 0 (0.0) | 2 (0.6) | 0.99 (χ2, 0.00) |
| SNRIs | 1 (0.9) | 1 (0.3) | 0.99 (χ2, 0.00) |
| SSRIs | 8 (7.0) | 8 (2.5) | 0.06 (χ2, 3.65) |
| Izidakamizwa ze-Endocrinological | |||
| Izidakamizwa ze-Antiandrogenic | 0 (0.0) | 3 (0.9) | 0.73 (χ2, 0.12) |
| Izidakamizwa ze-Antithyroid | 0 (0.0) | 1 (0.3) | 0.57 (χ2, 0.33) |
| Thyroxin | 2 (1.8) | 17 (5.2) | 0.20 (χ2, 1.61) |
| Corticosteroids | 3 (2.6) | 12 (3.7) | 0.80 (χ2, 0.07) |
| IDarbepoetin | 0 (0.0) | 1 (0.3) | 0.57 (χ2, 0.33) |
| Desmopressin | 0 (0.0) | 2 (0.6) | 0.99 (χ2, 0.00) |
| Dopamine agonists | 2 (1.8) | 4 (1.2) | 1.00 (χ2, 0.00) |
| Abaphikisi beDopamine | 4 (3.5) | 3 (0.9) | 0.14 (χ2, 2.19) |
| Iziyobisi zonyango | |||
| Iziyobisi ezichasayo | 3 (2.6) | 32 (9.8) | 0.02 (χ2, 5.05) |
| Insulin | 3 (2.6) | 23 (7.1) | 0.13 (χ2, 2.31) |
| Inkqubo yokuphefumula | |||
| Antihistamines | 4 (3.5) | 12 (3.7) | 0.85 (χ2, 0.04) |
| Beta2-agonist | 1 (0.9) | 3 (0.9) | 0.56 (χ2, 0.33) |
| Amachiza ahlobene ne-BPH / LUTS | |||
| I-5-alpha reductase inhibitors | 1 (0.9) | 6 (1.9) | 0.77 (χ2, 0.09) |
| I-Alpha-blockers | 1 (0.9) | 41 (12.6) | 0.0005 (χ2, 12.04) |
| Ezinye iziyobisi | |||
| Iziyobisi zeAnticholinergic | 1 (0.9) | 1 (0.3) | 0.99 (χ2, 0.00) |
| Immunomodulators / immunosuppressors | 3 (2.6) | 12 (3.7) | 0.80 (χ2, 0.07) |
| Proton pump inhibitors | 2 (1.8) | 33 (10.2) | 0.008 (χ2, 6.98) |
| Izidakamizwa ezichasene nezidakamizwa | 7 (6.1) | 14 (4.3) | 0.60 (χ2, 0.27) |
| Triptans | 0 (0.0) | 1 (0.3) | 0.57 (χ2, 0.33) |
| iivithamini | 2 (1.8) | 11 (3.4) | 0.59 (χ2, 0.30) |
| Iziyobisi | 0 (0.0) | 17 (5.2) | 0.03 (χ2, 4.84) |
| Ukubhema i-cigarette (No. [%]) | 0.02 (χ2, 7.56) | ||
| Abatshayi bamanje | 43 (37.8) | 80 (24.6) | |
| Ababhemayo abedlule | 1 (0.9) | 7 (2.2) | |
| Ungaze utshaye | 70 (61.3) | 238 (73.2) | |
| Ukusetyenziswa kotywala (naliphi ivolumu / iveki) (ayikho [%]) | 0.52 (χ2, 0.41) | ||
| Rhoqo | 88 (77.2) | 262 (80.6) | 0.16 (χ2, 1.93) |
| Ukusela utywala (1-2 L / iveki) | 26 (22.8) | 98 (30.2) | 0.96 (χ2, 0.00) |
| Ukuselwa kotywala (> 2 L / iveki) | 4 (3.6) | 10 (3.1) | |
| Iziyobisi ezingekho mthethweni (nayiphi na uhlobo) (No. [%]) | 24 (20.9) | 11 (3.4) | <0.001 (χ2, 34.46) |
| I-Cannabis / marijuana | 24 (20.9) | 9 (2.8) | <0.001 (χ2, 37.29) |
| ICocaine | 4 (3.5) | 0 (0.0) | 0.005 (χ2, 37.29) |
| Heroin | 0 (0.0) | 3 (0.9) | 0.73 (χ2, 7.92) |
Akukho mahluko wafunyanwa kulo naluphi na olunye usapho lweziyobisi (Itheyibhile 2).
Mncinci
Iigulane ze-ED zihlala zibonakalisa umkhwa wokubhema ugwayi
kunye nokusetyenziswa kweziyobisi ezingekho mthethweni (zombini isnabisi / i-marijuana kunye ne-cocaine) njengaye
kuthelekiswa namadoda amakhulu kuneminyaka eyi-40 (konke P ≤ 0.02). Akukho mahluko wafunyanwa ngokwasiselo sotywala phakathi kwamaqela (Itheyibhile 2).
itafile 3 Iinkcukacha zithetha (i-SD) imiba yee-fiveEE domains scores; hayi
Ukungafani okuphawulekayo kwagcinwa kwiphina i-domain ye-IIEF phakathi
abancinci nabasemagqabini amatsha e-ED. Ngokufanayo, amadoda ≤40 ubudala ubudala
ibonisa ukufana okufanayo kunye nokugqithisa okukhulu kwe-ED xa kuthelekiswa
nezigulane ezindala. Ngokufanayo, amazinga omnene, omnene ukuya kumodareyitha, kwaye
I-ED engamaphepha ayifani kakhulu phakathi kwamaqela amabini
(Itheyibhile 3).
| Ii-IIEF-domains (ithetha [SD]) | Izigulane ≤40 iminyaka | Izigulana> iminyaka engama-40 | P inani* |
|---|---|---|---|
| |||
| IIEF-EF | 12.77 (8.7) | 14.67 (8.4) | 0.23 |
| IIEF-IS | 5.9 (4.2) | 6.69 (4.1) | 0.33 |
| IIEF-OF | 7.51 (3.2) | 7.06 (3.5) | 0.49 |
| IIEF-SD | 6.98 (2.3) | 6.57 (2.1) | 0.36 |
| IIEF-OS | 4.95 (2.6) | 5.06 (2.5) | 0.82 |
| I-IIEF yobunzima† (Hayi [%]) | |||
| EF eqhelekileyo | 11 (9.3) | 39 (11.9) | 0.73 (χ2, 2.01) |
| Uluhlu ED | 16 (14.0) | 55 (16.8) | |
| ED elula ukuya kwi-ED | 10 (9.3) | 51 (15.8) | |
| ED ephakathi | 21 (18.6) | 48 (14.9) | |
| ED | 56 (48.8) | 132 (40.6) | |
ingxoxo
We
ukuphonononga ngokuphindaphindiweyo iqela elilandelelanayo laseCaucasian-European
amadoda asebenza ngokwesondo afuna uncedo lokuqala lwezonyango kwi-ED entsha
inkonzo enye yokuphululelwa kwabafundi ngokwexesha leenyanga ze-30 ukwenzela ukuba
ukuvavanya ukuxhaphaka kunye neempawu zabantu ngabanye ≤40 ubudala ubudala
xa kuthelekiswa namadoda amakhulu kunama-40 iminyaka ngexesha lokuxilongwa kwe-ED.
Sifumene ukuba omnye kwabesilisa abane abane-ED wayemncinane kuneminyaka eyi-40.
Ngaphezu koko, inani elifanayo labathathi abancinci nabasabadala be-ED benza
isikhalazo se ED. Ngokufanayo, izigulane ezincinane kunye nabadala
ifunyenwe kwisizinda ngasinye se-IIEF, oko kubandakanya umnqweno wesini, i-orgasmic
umsebenzi kunye nokwaneliseka jikelele. Ngoko ke, ukubonwa njengento
Yonke yabonakala ngathi njengomfanekiso obangeleko ukusuka kwiklinikhi yansuku zonke
ku sebenza.
ED iimeko kunye
iziganeko zonyango kunye neengxaki zentlalo ezenzekayo
ukuvavanywa ngokubanzi kwizifundo ezahlukeneyo [7-10, 13, 14, 25]. Ngokubanzi, iminyaka iyabonwa njengona nto inempembelelo, ngezifundo eziliqela ezibonisa ukwanda okukhulu kwe-ED kunye nobudala [7, 8, 26];
Ngokomzekelo, idatha evela kwi-Massachusetts Male Aging isifundo iphelile
loo minyaka yayingu-variable ehambelana kakhulu ne-ED [7]. Ngaphandle kweeminyaka, ezinye iimeko ezininzi zonyango ziye zadibaniswa kakhulu ne-ED [7, 10, 12-14, 26].
Kwixesha lokuguga, abantu abesilisa bahlala behlushwa kwesinye
okanye ngaphezulu kweemeko ezichazwe ngentla apha, kwaye akunjalo
Akumangalisi ukuba bahlala bekhalaza nge-ED. Ngenxa yezi zizathu, uninzi lwazo
Izifundo ze-epidemiological ezijongene nokuxhaphaka kwe-ED kunye neengqikelela
zenziwa kwinani labantu abadala kuneminyaka eyi-40 ubudala;
Ngokuchanekileyo, zifundo ezimbalwa kuphela ziquka idatha ukusuka kumncinci
ngabanye [14-16, 26, 27].
Ngokubanzi, idatha evela kwezi zifundo kamva ibonise ukuba i-ED ayiyinto inqabile
imeko nakwabeselula. Mialon et al., Umzekelo, ingxelo
ukuba ukusabalalisa kwe-ED kwakuyi-29.9% kwiqela labeselula abaseSwitzerland [15]. Ngokufanayo, uPonholzer et al. [14] afumane amazinga afanayo e-ED kwisiqulatho esilandelayo samadoda aneminyaka eyi-20-80
iminyaka ethatha inxaxheba kwiprojekthi yokujonga impilo kwindawo yaseVienna.
Ngokufanayo, uMartins noAbdo [16] esetyenzisiweyo idatha esuka kwinqanaba le-cross-sectional apho amadoda e-1,947 aneminyaka eyi-18-40 iminyaka
abadala baqhagamshelana nakwiindawo zikawonke-wonke ze-18 ezinkulu zaseBrazil kunye
udliwano-ndlebe usebenzise i-questionnaire engaziwa; ngokubanzi, i-35% yabo
abantu baye babika ezinye iibakala zeengxaki ze-erectile.
A
Amandla amakhulu esihlalutyo sethu siphumelela ekubeni sichaze ngokuchanekileyo
ukuvavanya ukukhula kunye neempawu ze-ED kumadoda amancinci
ukusuka kwiqela lezigulane eziye zafika ngokusisigulana sethu
ikliniki efuna unyango lokuqala lwe-ED; kulo mongo, sifumene oko
kwikota yezigulane ezijongene ne-ED kwimisebenzi yeklinikhi yansuku zonke
bangamadoda angaphantsi kweminyaka yobudala be-40. Oku kuqinisekisa ngokucacileyo ngaphambili
idatha ye-epidemiological ukusuka kwizifundo ezixhomekeke kubemi, oko kuchaza oko
I-ED ayiyona nje ingxaki yomntu oguga kunye nomsebenzi we-erectile
ukuphazamiseka kwamadoda amancinci akufanele kubekwe ngonyango. Wethu
Ukubonakaliswa kwimeko yeklinikhi yansuku zonke kwenza okungakumbi malunga
kuqwalasela ukusebenza kwansuku zonke oogqirha abangenawo
ukuqhelana nempilo yesondo ngesini; eneneni, enikezwe ngokuphantsi
amazinga ovavanyo lwe-ED ngabasebenzi abaqhelekileyo kwizigulane ezindala kunokuba
iminyaka 40 [28], sinoyika kakhulu ukuba i-ED okanye ukusetyenziswa ngokwesondo ngeyona nto ingaphinda iphandwe kumadoda amancinci [29].
The
Ukufunyaniswa kohlalutyo lwethu kubonise ukuba izigulane ezincinci zisehlabathini lonke
enempilo xa kuthelekiswa namadoda amakhulu kuneminyaka eyi-40, ebonisa i-CCI ephantsi
amanqaku-kunye nenani elincinci lemithi, ngakumbi
Ii-CVDs, i-BMI ephantsi, kunye nokuxhaphaka kwe-hypertension.
Ngokufanayo, kwaye akumangalisi ukuba abantu abancinci babephethe i-TT ephezulu
amanqanaba xa kuthelekiswa nezigulane ezidlulileyo kuneminyaka eyi-40, ngaloo ndlela zivumelana
Uninzi lweengxelo ze-epidemiological phakathi kwabantu baseYurophu abakhulileyo [2].
Ngokubanzi, le nkcukacha zekliniki ziqinisekisa abo bafunyanwa kwi
Uphando lwaseBrazil, olwalunakufumanisa naluphi na umbutho obalulekileyo
liqinisekisa ubungqina bezinto ezinobungozi be-ED ezifana nesifo sikashukela kunye nee-CVD kumadoda
uneminyaka eyi-18-40 ubudala [16].
Ngokubanzi, oku kwahluka kulindeleke, kunika i-ED
Amadoda aselula aqhelekile axhulumana neengqondo ezininzi kunye
izinto ezibandakanyekayo ezibangela ukuba izizathu ezinobangela
[8, 30, 31]. Ukongezelela, uMialon et al. [15] wabonisa ukuba ulwahluko oluphambili phakathi kwabaselula nabasemadeni ase-ED bekunjalo
impilo yengqondo kunye nesimo sengqondo ngemithi. Kwiqela lethu le-ED
izigulane, safumanisa ukuba amadoda amancinci ayedla ngokukhawuleza
ukubhema ucuba kunye neziyobisi ezingekho mthethweni (okt, i-cannabis / marijuana kunye
cocaine) kunezigulane ezindala. Idatha yangaphambili malunga nokusetyenziswa okungapheliyo
iziyobisi-ingakumbi i-cannabis, i-opiates kunye ne-cocaine-ibonise akukho
ubungqina obungabonakaliyo bokuqhagamshelana ne-ED [32-34],
kwaye ngokuqinisekileyo iimpendulo eziliqela ziphakanyiswe indima ebangela umdla
ukutshaya utshayi ongapheliyo ekukhuthazeni ukukhubazeka kwemisebenzi ye-erectile
kubantu abatsha [7, 34-37].
Ngenxa yesimo esichazayo sesifundo sethu, asikwazi ukucinga
ukuba ezi ndlela zokugqibela zendlela yokuphila zingabandakanywa ngokucacileyo kunye
ukuqala kwe-ED kumadoda amancinci, kodwa kuyacaca ukuba kuqikelele ukuxilisa
ukuba bobabini banokudlala indima kunye nezinye izinto
ukukhuthaza ukukhubazeka komsebenzi we-erectile. Ngokwahlukileyo, oku kungapheliyo
umlutha wezinto zokuzonwabisa-ezinokuba nazo
ukulimaza kungekhona kuphela kwimpilo yesondo-iqinisa ngakumbi inkxalabo
isakhelo esivela kwimbono yethu, oko kukuthi, isine kwikota yabantu
eze ukufuna uncedo lokuqala kwi-ED phantsi kwe-40 iminyaka, kwaye ihlala ingxelo
ukusetyenziswa okungapheliyo kwezinto ezinobungozi, ngokuqhelekileyo kwanokungekho mthethweni.
Gqi beleni,
Singahlolwa iqondo le-psychometrically rates of ED uqobo kumaqela amabini;
Ukulinganiswa okulinganayo kwama-ED severities kwafunyanwa phakathi kwamaqela. Ku
Kubaluleke kakhulu, malunga nesiqingatha sabantu abangaphantsi kweminyaka eyi-40 ubudala
waxhatshazwa ngu-ED ngokubhekiselele kwiCappelleri et al. [24],
ukuba le nqanaba iyafana nento ebonwa kumadoda amadala.
Ngokombono wethu, oku kufumanisa kuza kugqiba ukuba
ukuphazamiseka kokumiswa kungabonwa njengokuba kungasebenzi kumncinci
izigulane njengamadoda amadala, ngoko kuxhasayo ukuba le ntlobano yesondo
Ingxaki iya kulungelelaniswa ngokwaneleyo kwimihla ngemihla yonyango
yonke iminyaka. Ngokufanayo, sihlolisise ukuba izigulane ze-ED ezincinane kunye nakwezinye
zifunyenwe ngokubhekiselele ekusebenzeni ngokwesini, njengoko kuchazwe ngokusebenzisa
ezahlukeneyo ze-IIEF. Iyahambelana nedatha edlulileyo ibonisa oko
Ukutshintsha kwexesha elide kwimimandla emihlanu yesifundo sezesondo kunye kunye
ixesha elidlulele [38],
asizange sikubone nayiphi na into eyahlukileyo kwisiza ngasinye se-IIEF
phakathi kwamaqela. Ngaloo ndlela, kuya kwenzeka ukuba ucacise ukuba,
kunye nezizathu ezahlukileyo ezibangelwa i-ED, isixhobo se-IIEF asikwazanga
uyakwazi ukubandlulula ngokuthe ngqo u-pathophysiology emva kwe-ED. Kanjalo,
nangona i-ED, njengoko ichazwa ngokucacileyo kunye nomsebenzi we-IIEF-erectile
kwisizinda, kuboniswe kwi-akhawunti kwi-CCI ephezulu, enokuba yiyo
kuthathwa njengommeli onokwethenjelwa wezinga eliphantsi lempilo yabantu,
kungakhathaliseki i-etiology ye-ED [3], UDeveci et al. [39] ngaphambili behlulekile ukubonisa ukuba i-IIEF inakho ukukwazi
calule phakathi kwe-ED kunye no-psychogenic. Nangona kunjalo, kunjalo
Ngokuqinisekileyo ukuba uphando oluninzi lubonisa ukuba i-ED ingaba
ukubonakaliswa ngokubanzi kweziganeko zeCVD [40, 41]. Phakathi kwabo, u-Chew et al. [41],
Ngokomzekelo, uphando nge-ED njengendlela yokucwangcisa iziganeko ze-CVD kwi
Inani labantu abano-ED abaphakathi kwe-20 kunye ne-89 yeminyaka ubudala; ezi
Ababhali bafumene ingozi enkulu enxulumene neziganeko ze-CVD kwizigulane ze-ED
ncinane kuneminyaka eyi-40. Ngokuchasene, ukuhla kwexabiso lokugqibela eliphantsi kwe-ED
Iziganeko ze-CVD zabonwa ngabantu abadala [41].
Ngokubanzi, ezi ziphumo ezidlulileyo kunye neziphumo zethu zangoku zingabonisa
Ukuhlolwa kwe-ED yindlela ebalulekileyo yokuchonga abancinci kunye
amadoda angama-middle-aged abaxabisekileyo abanomdla wengozi yengqondo
uvavanyo kunye nokungenelela kwonyango olulandelayo. Nangona uninzi lwazo
Izigulane kweli qela leminyaka ziza kuba zihlupheke kwi-ED engaqhelekanga,
kukho inxalenye yabo yokukhalaza nge-organic ED
i-label-wide spectrum etiologies, kunye ne-ED ibe yedwa umakishi we-sentinel
ukungonakaliswa kwempilo yezempilo (oko kukuthi, i-atherosclerosis). Kule
umxholo, u-Kupelian et al., umzekelo, ufunda abantu base 928 amadoda
ngaphandle kweMeTs, wabonisa ukuba i-ED yayiyilungelelaniso lokuphuhlisa okulandelayo
I-MeTS kwizigulane ezine-BMI eziqhelekileyo kwisiseko [42],
ngaloo ndlela ugxininisa ukubaluleka kwe-ED njengenjongo yokunceda abantu abaselula
ukuba nexesha elide lokuphila impilo, enokuyilungisa ingozi
izifo ezifana neswekile nesifo se-CVD, phakathi kwabanye.
yethu
ukufundisisa akusiyo imingcele. Okokuqala, iqela lethu elincinane
yamadoda inganciphisa intsingiselo yeziphumo zethu, ngelixa singena
akhawunti kuphela ezo gulane ezithunyelwe kwiyeza zonyango
iklinikhi yokugula ingase iqinisekise ukhetho olukhethiweyo ngenxa yobunzima
ye-ED, ngaloo ndlela ekhokelela ekuphoseni inani labantu abane-ED kunye ne-ED
abangenakukhuthazwa ukuba bafune uncedo lwezokwelapha. Nangona kunjalo, sicinga ukuba oku
Iphutha leendlela eziza kubakho ngokufanayo kwimibini yobudala, ngaloo ndlela
ingabonakali ukubaluleka kwezi ziphumo. Okwesibini, asizange sihlole
amazinga okudakumba okanye uxhalabo usebenzisa izixhobo zokusebenza ezicetywayo.
Kulo mongo, ulwalamano lwe-causal phakathi kwe-ED kunye nokuba
ukuxinezeleka okanye uxhalaba, okanye zombini, mhlawumbi i-bidirectional; kwenene, ED
inokufunyanwa emva kokudandatheka okanye uxhalaba oluya kuba nalo
ngenxa yoluphi usebenziso lwezesondo. Ukuba nesixhobo esinako
ukucalula le meko inokuba yinto ebalulekileyo yeklinikhi
ngakumbi kubemi abemi. Okwesithathu, ukuhlalutya kwethu akuzange kwenzeke
kuvavanya ngokukodwa imbali yesigulana kunye nokwabelana ngesondo ngaphezulu kwe
ixesha elivisayo. Kule nkalo, uMartins no-Abdo [16] wabonisa indlela ukungabi nolwazi ngolwabelana ngesondo kwizigulane ezincinane kakhulu
idibene ne-ED ngenxa yokwenza ukwesaba kunye nokungabaza okuphakanyiswe ngamathambo
kunye nokulindelekanga okungenakwenzeka. Iziguli ezinobunzima kulo lonke
Ekuqaleni kobomi babo bobulili babonisa ukubonakala okuphezulu kwe-ED, mhlawumbi
eveliswa ngumjikelezo wokuxhalabisa kunye nokwehluleka ekugqibeleni kuyonakalise
ukusebenza komntu ngokwesondo [43].
Ekugqibeleni, ukuhlalutya kwethu akuzange kuthathe ingqalelo kwi-socio-economic
imiba yobomi; Ngokwenene, imali eyongezelelweyo yengeniso yendlu yaboniswa
kulungiswe ngokuqinisekileyo nokuziphatha okufuna unyango, ngelixa
ukungahlawulwanga kwemali ekugqibeleni kungabonakalisa umqobo [44].
Noko ke, sinqume ukuba singabizi inkcazelo yengeniso ngenxa yezantsi
izinga lokuphendula kwimali engenayo esiyifumanayo kwimpilo yangempela
uhambo lwezonyango ngexesha lokutyelela i-ofisi.
izigqibo
In
ngokuchasene noko kuye kwabikwa zifundo zabantu
ukwanda kwe-ED kwizigulane eziselula, iziphumo zethu zibonisa ukuba enye
Amadoda amane afuna uncedo lwezokwelapha kwi-ED kwimihla ngemihla
ikliniki yokugulisa isiselula esingaphantsi kweminyaka eyi-40. Ngaphezu koko,
phantse isiqingatha sabaselula abahluphekileyo kwi-ED enkulu, kuba ngulo
inani elifana nelo liyabonwa kubantu abadala. Ukuhambisa
kwindlela yokwelapha yemihla ngemihla, ukufunyanwa kwangoku kusikhuthaza ukuba siqhubeke
ucacise ukubaluleka kokuthabatha unyango kunye nesondo
imbali kunye nokwenza uvavanyo olupheleleyo lwangaphakathi kubo bonke abantu abanalo
ED, kungakhathaliseki ubudala babo. Ngokufanayo, kunikwa izinga eliphantsi lokufuna
Uncedo lonyango lweengxaki ezinxulumene nempilo yesondo, ezi ziphumo
ukubonisa ngakumbi imfuneko yokuba ababoneleli bezempilo banokubuza
malunga nezikhalazo zesini, mhlawumbi nangakumbi kumadoda amancinci kunoko
Iminyaka eyi-40 ubudala. Ngenxa yokuba ubungakanani beesampula esikhoyo ngoku, bunokwenzeka
asikwazi ukufumana izigqibo eziqhelekileyo; Ngoko ke, izifundo ezingaphezulu
iisampula ezixhomekeke kubemi zifuneka ukuba ziqinisekise ezi ziphumo kunye
ukuqhubela phambili ukubonakalisa indima enokubaluleka kwe-ED ubunzima njenge-harbinger
lweengxaki zezokwelapha kumadoda angaphantsi kweminyaka yobudala be-40.
Ukugqubana kwemidla: Ababhali babika ingxabano yomdla.
Inkcazo yoBungqina
Udidi 1
- (a) UkuCwangciswa kunye nokuDalwaPaolo Capogrosso; Andrea Salonia
- (B) Ukufunyanwa kweDathaMichele Colicchia; Eugenio Ventimiglia; Giulia Castagna; Maria Chiara Clementi; Fabio Castiglione
- (c) Uhlalutyo kunye nokuchazwa kwedathaNazareno Suardi; Andrea Salonia; UFrancesco Cantiello
Udidi 2
- (a) Ukuqulunqwa kweSiqenduPaolo Capogrosso; Andrea Salonia
- (B) Ukubuyiselwa kwakhona kwiNkcazelo yoBuchuleAndrea Salonia; Alberto Briganti; Rocco Damiano
Udidi 3
- (a) Ukuvunyelwa kokugqibela kweCandelo eligqityiweyoAndrea Salonia; Francesco Montorsi
Ucaphulo
- 1, , . Ukuguqula umngcipheko wezinto zokukhusela nokunyanga i-erectile dysfunction. J Sex Med 2013;10:115-119.
- 2, , , , , , , , , , , , , , , , , , , , Iqela leSifundo se-EMAS. Ezihlobene nobudala
utshintsho kwimpilo jikelele kunye nezokwezesondo kwindoda eneminyaka ephakathi kunye nangaphezulu:
Iziphumo ezivela kwisiFundo se-Aging yase-Yurophu (EMAS). J Sex Med 2010;7:1362-1380. - 3, , , , , , , , , . Is
i-erectile disys functional proxy ethembekileyo yesimo sempilo yabantu besintu?
Ityala le-International Index ye-Erectile Function-Erectile
Idilesi yomsebenzi. J Sex Med 2012;9:2708-2715. - 4, , , , , , , , . Erectile
ukusabalalisa ukungasebenzi, ixesha lokuqalisa kunye nokuzibandakanya nemingcipheko
kwizigulane ezilandelelanayo ze-300 ezineentlungu zesifuba esibuhlungu kunye ne-angiographically
ugqirha wesifo somgulo. Eur Urol 2003;44:360-364. - 5, , , , , , , . I-Erectile i-dysfunction kunye nobungozi bemicimbi yesifo se-cardiovascular: I-meta-analysis of seven counts studies. J Sex Med 2010;7:2805-2816.
- 6, , . Ukungasebenzi kwe-Erectile kunye nomngcipheko wesifo senhliziyo: Uhlalutyo lwe-Meta-uphando lwamaqela aphakathi. J Am Coll Cardiol 2011;58:1378-1385.
- 7, , , , . Ubuthathaka kunye nama-correlates aloo ngonyango kunye neengqondo: Iziphumo zeSifundo se-Male Male Aging Study. J Urol 1994;151:54-61.
- 8, , . Ukungasebenzi kwezesondo e-United States: Ukunyamekela nokucwangcisa. JAMA 1999;281:537-544.
- 9, , , , . Ubuninzi be-erectile dysfunction: Ukuphononongwa ngokuchanekileyo kwezifundo ezisekelwe kubantu. Int J Impot Res 2002;14:422-432.
- 10, , , , , , . Ukukhula
kunye nemingcipheko ye-erectile ukungasebenzi komntu wesifo sikashukela,
uxinzelelo lwegazi, okanye zombini izifo: uphando lwentlalo phakathi kwe1,412 Israel
abantu. KwiKliniki yeKardiol 2003;26:25-30. - 11, , , , , , . Ubuninzi kunye nokuqikelela kweengxaki zezesondo kumadoda aneminyaka eyi-75-95 iminyaka: Isifundo esisekelwe kubantu. J Sex Med 2012;9:442-453.
- 12, , , , , , , , , . Critical
Uhlalutyo lolwalamano phakathi kwezinto zesondo kunye nezantsi
iimpawu zomchamo ngenxa ye-prostatic hyperplasia. Eur Urol 2011;60:809-825. - 13, , , , , , , , , , . Ukuphindaphinda kunye nezigqibo ze-erectile disysction in Italy. Eur Urol 2000;37:43-49.
- 14, , , , , . Ubunzima kunye nemingcipheko ye-erectile ukungasebenzi kwi-2869 amadoda esebenzisa imibuzo eqinisekisiweyo. Eur Urol 2005;47:80-85.
- 15, , , , . Ukungasebenzi kwezesondo phakathi kwamadoda amancinci: Ubuninzi kunye nezinto ezinxulumene nazo. J Adol Health 2012;51:25-31.
- 16, . Ukungasebenzi kwe-Erectile kunye nemibandela ehlangeneyo kumadoda eBrazil aneminyaka eyi-18-40 iminyaka. J Sex Med 2010;7:2166-2173.
- 17, , , , . Uhambo oluya kwiindawo zezicelo zoncedo olunikezwa kwiingcali zezobisi ngezesondo: Ukuzisa ukuxhalabisa ngokwesini. J Sex Med 2007;4:762-770.
- 18
- 19, , , . Indlela entsha yokwenza uhlengahlengiso olusisigxina ekufundweni kwexesha elide: Uphuhliso kunye nokuqinisekiswa. J Chronic Dis 1987;40:373-383.
- 20AmaZiko eZiko lezeMpilo, iNational Heart, Lung, ne-Blood Institute. Izikhokelo zenklinikhi ekuchongeni, ukuvavanya, kunye nokunyanga kokukhululeka nokugqithisa kubantu abadala-Ingxelo yoBungqina. Obes Res 1998;6(umrhumo):51-210S.
- 21, , , , , , , , , , , , American Heart Association; I-Heart Heart, iLung, ne-Blood Institute. Ukuqondwa
kunye nokulawulwa kwesifo se-metabolic: i-American Heart
Umbutho / iNtliziyo yeSizwe, iMilung, ne-Blood Institute yeScientific
inkcazo. Ukuhamba 2005;112:2735-2752. - 22I-American Association ye-Endocrinologist Clinic. Izikhokelo zonyango ekwenzeni iiklinikhi zokuvavanywa kunye nokunyangwa kwe-hypogonadism kwizigulane zabantu abadala-i-2002 update. Endocr Pract 2002;8:440-456.
- 23, , , , , . I-Index ye-International Index ye-Erectile Function (IIEF): Isilinganisi samanani amaninzi ekuhloleni usebenziso lwe-erectile. Urology 1997;49:822-830.
- 24, , , , . Ukuvavanya uvavanyo lwe-erectile domain domain ye-International Index ye-Erectile Function. Urology 1999;54:346-351.
- 25, . Isiganeko
ye-erectile disysction kunye neziganeko zezigulane zangaphambili kwaye
emva kokusungulwa kwe-sildenafil e-United Kingdom: Ukuwela
isifundo secandelo kunye nezigulane. Br Med J 2003;22:424-425. - 26, , , , , . I-Epidemiology ye-erectile dysfunction: Iziphumo ze "Cologne Male Survey". Int J Impot Res 2000;12:305-311.
- 27, , , , , . Ukukhula
kunye nezimo ezizimeleyo zobungozi be-erectile eSpain: Iziphumo
I-Epidemiologia de la Disfunction Erectil I-MAsculina Study. J Urol 2001;166:569-574. - 28, , , , , , , Iqela leSifundo se-EDEN. Ulawulo lwe-erectile ukungasebenzi ngokuqhelekileyo. J Sex Med 2009;6:1127-1134.
- 29, , . "Ndiza kujonga kwiwebhu kuqala": Izithintelo kunye nokoyisa izithintelo ekubonisaneni nokungasebenzi ngokwesondo phakathi kwabafana. Swiss Med Wkly 2010;140:348-353.
- 30. Iingxaki zobundlobongela kubantu abaneempilo kunye nabaxinezelekileyo. Int Clin Psychopharmacol 1998;13(XLUMX):S1-4.
- 31, , , , , , , , , , , . Inatomy, physiology, kunye ne-pathophysiology ye-erectile disys function. J Sex Med 2010;7:445-475.
- 32, , , , , , . Ukungasebenzi ngokukhawuleza kokuqala njengommakishi we-vasculogenic erectile ukungasebenzi kwiintlobo ezisemthethweni zabasebenzisi be-cannabis. Int J Impot Res 2008;20:566-573.
- 33, . Impembelelo yokusetyenziswa kwesininzi kwizempilo zesini. J Sex Med 2011;8:971-975.
- 34, , . Ukubhema i-cigarette: Ubungozi obuzimeleyo bokungabi namandla? Am J Epidemiol 1994;140:1003-1008.
- 35, , , , . Epidemiology
ukusetyenziswa kwe-erectile kumazwe amane: Ukufunda ngokubanzi komhlaba
ukuxhaphaka kunye ne-correlates ye-erectile dysfunction. Urology 2003;61:201-206. - 36, , , . I-Epidemiology ye-erectile dysfunction: Indima yezokwelapha kunye neendlela zokuphila. Urol Clinic North Am 2005;32:403-417.
- 37, . Efanelekileyo
iziphumo ze-nicotine ekuvukeleni ngokwesini kunye nokuzimela ngokwesini
Amadoda angabonakaliyo: Uvavanyo olulinganiselwe, oluphindwe kabini, lube lukhuni lwe-placebo. J Sex Med 2008;5:110-121. - 38, , , , , , , . Longitudinal
ukuvavanya umsebenzi wesini kwindoda yamadoda: I-Olmsted county
ukufundisisa iimpawu ze-urinary kunye nesimo sempilo phakathi kwamadoda. J Sex Med 2009;6:2455-2466. - 39, , , , , . Ngaba iNkcazo ye-International ye-Erectile Function ingahlukanisa phakathi komsebenzi we-erectile we-organic and psychogenic? BJU Int 2008;102:354-356.
- 40, , , , , , . Erectile
ukungasebenzi ngendlela ehambelana nezifo zesifo senhliziyo
Inani labemi baseDutch: Iziphumo ezivela kwi-Study Krimpen. Int J Impot Res 2008;20:92-99. - 41, , , , , , , , . I-Erectile i-dysfunction njenge-predictor for events subsequent atherosclerotic cardiovascular: Iziphumo ezivela kwi-data-linked data study. J Sex Med 2010;7:192-202.
- 42, , , , . I-Erectile i-dysfunction njenge-predictor of syndrome syndrome kubantu abaguga: Iziphumo ezivela kwi-Massachusetts Male Aging Study. J Urol 2006;176:222-226.
- 43, , , , , . Uxwebhu olubalulekileyo kwi-erectile dysfunction: Iinkalo ezibalulekileyo ekunyamekelweni kwesigulane nge-erectile dysfunction. Int J Impot Res 2004;16(I-2 suppl):S26-39.
- 44, , , , , , . I-correlates ye-PDE5i phakathi kwezifundo ezinobungozi be-erectile kwimilinganiselo emibini yoluntu. J Sex Med 2011;8:3051-3057.
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