Ukuvuselela kwe-Neurochem. 2013 Apr 13.
Lee DK, Owu JH, Shim YB, Choe ES.
imvelaphi
ISebe lezeNzululwazi zebhayoloji, iYunivesithi yeSizwe yasePusan, i-63-2 Pusandaehak-ro, Kumjeong-gu, Pusan, 609-735, Korea.
Abstract
Ukusebenza kweprotein kinase G (PKG) kuye kwanyanzeliswa kummiselo weplastiki ye-synaptic kwingqondo. Olu phononongo lwenziwe ukumisela ukubandakanyeka kwe-PKG-enxulumene ne-dopamine D2 (D2) receptors kummiselo wokukhutshwa kwe-dopamine, intetho ye-osBFosB kunye nomsebenzi we-locomotor ekuphenduleni ukubonakaliswa kwecocaine okuphindaphindiweyo. Ukuphindaphindwa kwenaliti yenkqubo yecocaine (20 mg / kg), kanye ngemini kangangeentsuku ezisixhenxe ezilandelelanayo, ukonyusa i-cyclic guanosine monophosphate (cGMP) kunye ne-extracellular dopamine concentrations kwi-dorsal striatum. Ukuthintela i-neuronal nitric oxide synthase (nNOS), cGMP okanye i-PKG kunye nokukhuthaza ii-receptors ze-D2 kunciphise ukonyuka okuphindaphindiweyo kwe-cocaine. Iziphumo ezifanayo zafunyanwa ngokudibanisa i-nNOS, cGMP okanye i-PKG inhibition ngokukhuthaza ii-receptors ze-D2. Ngokudibeneyo kwezi datha, ukuthintela i-PKG, ukukhuthaza ukwamkelwa kwe-D2, kunye nokudibanisa i-PKG inhibition kunye nokukhuthaza i-D2 receptors kunciphise ukunyuka okuphindaphindiweyo kwe-cocaine kwintetho ye-ΔFosB kunye nomsebenzi we-locomotor.
Ezi ziphumo zibonisa ukuba ulawulo lwe-receptors ze-D2 eyenziwa yi-PKG emva kokuphindaphindwa kwe-cocaine luxanduva lokukhupha ukukhutshwa kwe-dopamine kwaye luzinze utshintsho lwexesha elide kwi-gene expression kwi-dopamine terminals kunye ne-gamma-aminobutyric acid neurons ye-dorsal striatum, ngokulandelanayo. Oku kukonyuka kunganegalelo kutshintsho lweendlela zokuziphatha ekuphenduleni ekuvezweni okuphindaphindiweyo kwi-cocaine.
;