Neuropsychopharmacology. I-2016 Jan 21. doi: 10.1038 / npp.2016.11.
I-Balodis IM1, Kober H1, I-Worhunsky PD1, Stevens MC2, I-Pearlson GD1,2,3, Carroll KM1, Potenza MN1,3,4.
Abstract
Ngelixa ulungiso lomvuzo lubonakala lutshintshile ukuba likhoboka, iziimbalo ezimbalwa zophando zilandelela utshintsho olusebenzayo emva kwonyango okanye zinxulumene nezixhobo zokunciphisa iziyobisi. Uphononongo lwangoku luvavanye utshintsho lwe-neuro-olusebenzayo kwinkqubo yokulungisa ukuxhomekeka kwecocaine (CD) kwangaphambi nangonyango ukumisela ukuba olutshintsho luhambelana nezalathi-nkqubela zesiphumo sezonyango. Izinto ezifuna unyango kwi-CD eziphuma kunyango (N = 29) zisebenza ngendlela engummangaliso ngelixa zisenza umsebenzi wokulibazisa wokukhuthaza ukunyangwa kunye nonyango lwasemva kwexesha. Imigca ye-MIDT ilindelekile ukusuka kwizigaba zesiphumo sokuhlawulwa / kwilahleko. Iimpawu zokuqhawula isisu (umchamo ongekho mgangathweni, iintsuku ezingafunekiyo kwi-cocaine ngexesha lokulandela) zaqokelelwa kunyango kwaye ziye kuthi ga kunyaka omnye kamva. Abathathi-nxaxheba abalawulayo (HC) (N = 28) baphinde baskena kabini nge-MIDT. Inxulumene nonyango lwangaphambi kokuthatha inxaxheba, kunyango lwenqanaba lonyango lwe-CD lubonise ukonyuka komvuzo wolindelo kumbindi wesibeleko, thalamus nakwisiqhelo (p.I-FWE<0.05). Ukonyusa imisebenzi ye-midbrain ehambelana nokuyeka i-cocaine ngexesha lokulandela unyaka we-1. Umsebenzi we-Ventral striatal (VS) ngexesha lokulahleka kolindelo olunxulunyaniswe ngokungalunganga kunye nezikrini ezibi zomchamo. Iziphumo zokuvavanywa kwakhona kweqela le-HC kubonise ukwehla kwemisebenzi yecortex yangaphambili ngexesha lokuphumelela. I-CD-HC yeqela-ngexa lexesha umahluko utyhile ukwanda komgangatho ophantsi ongaphambili we-gyrus kwiqela le-CD ngexesha lezigaba ezilindelekileyo kunyango lwasemva konyango. Kubathathi-nxaxheba be-CD, ukonyuka komsebenzi wonyango lwasemva kwexesha kwimimandla engafakwanga dopamine iphakamisa ukwehliswa kwemiqobo kulindelo lokutyikitywa kwemivuzo engeyiyo yeziyobisi. I-Midbrain kunye neempendulo ze-VS zinokumela ii-biomarkers ezinxulumene nokuthintela i-CD. Utshintsho olunxulumene ne-neurobiological enxulumene nokuzibamba lwenzeka kwimimandla efanayo ngexesha lokusebenzisa kwaye inokusetyenziselwa ukujonga inkqubela phambili ngexesha elifutshane kunye nexesha elide.
I-Neuropsychopharmacology yamkelwe inqaku lokuqala elikwi-intanethi, i-21 kaJanuwari 2016. doi: 10.1038 / npp.2016.11.
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