Neurotoxicol Teratol. Umbhalo obhaliweyo ifumaneka kwi-PMC 2009 Septemba 1.
Ishicilelwe kwifomu yokugqibela ehleliweyo njenge:
Ishicilelwe kwi-intanethi 2008 April 22. ikhonkco: I-10.1016 / j.ntt.2008.04.002
Inguqulelo yokugqibela yomhleli yeli nqaku iyafumaneka apha Neurotoxicol Teratol
Bona amanye amanqaku ku-PMC Wisdom nqaku epapashwe.
Abstract
Inkqubo ye-neural ejongene nokukhula komngcipheko wokufikisa kwinqanaba lokufikiswa kweziyobisi akucaci. Siphanda ukuba ngaba ukungafani kobudala kwi-dopamine neurotransuction kungachaza iziphumo eziphuculweyo zekhemikhali yomlinganiso kwi-periadolescent rat. Ukunyusa ngombane isixokelelwano se-medial forebrain bundle ye-anesthetised post-natal age 28 yeentsuku (PN28) kunye ne-PN65 rats elicited dopamine ukukhupha kwi-caudate nucleus kunye ne-nucleus accumbens core ngaphambi nangemva kwe-15 mg / kg ye-cocaine ip extracellular dopamine ye-FXX elandelayo ye-PNX I-65 kunye ne-28Hz inkuthazo nakwi-PN20 i-nucleus eqokelela emva kokunyusa kwe-60Hz. I-cocoaine yonyuse ugxininiso lwe-dopamine ephakanyiswe yi-65 Hz inkuthazo ye-60-emntwini omdala, kodwa iphantse ibe li-20-fold in periadolescent caudate. Iqondo lokukhutshwa kwe-Dopamine lalingaphantsi kwi-periadolescent caudate nangona ukucaciswa ngokupheleleyo kwe-dopamine kwakufana nokwabantu abadala. I-periadolescent caudate iphumelele imigangatho yabantu abadala yokucoca ngokubuyisela i-V esezantsimax ngokudibana okukhulu. Ukulawulwa ngamandla kwe-dopamine ye-extracellular ngokwenyusa okuphezulu / umda wokukhupha kwi-periadolescents kukhokelele kukonyuka okukhulu emva kwe-cocaine. Kwi-nucleus accumbens, ukukhutshwa kwe-dopamine kunye ne-Vmax babephantsi kwi-periadolescents kunabantu abadala, kodwa ukuthathwa kokuhambelana kunye neziphumo zecocaine zazifana. Ukungalingani kwe-dopamine neurotransuction kwi-dorsal striatum kungasenza ukuba iimpendulo ezizizo kwii-psychostimulants zikwimigangatho yokufikisa kwaye iphakamise indlela yokuba semngciphekweni omkhulu wabantu abakwishumi elivisayo ukuba likhoboka leziyobisi.
Internet: Uphuhliso, umlutha, voltammetry, dopamine neurotransuction, cocaine, ubutsha
izifinyezo
- PN
- emva-kwendalo (ubudala)
- [DA]p
- uxinzelelo lwe-dopamine ekhutshiweyo ngesiphumo sediphu
- [DA]max
- olona xinzelelo luphezulu lwe-dopamine
Imihlathi
Iphepha elichazayo ukuba awusenanto oyifunayo: Le fayili yeFayile yombhalo wesandla ongabhalwanga owamkelwe ukushicilelwa. Njengenkonzo kumakhasimende ethu sinika le ngcaciso yokuqala kwincwadi yesandla. Umbhalo wesandla uza kufumana ukukopishwa, ukufakela, nokuphonononga ubungqina obunokubakho ngaphambi kokuba kukhutshwe kwifomu yayo yokugqibela. Nceda uqaphele ukuba ngexesha lokuveliswa kweeprogram ezinokuthi zifumaneke ezinokuthi ziphazamise umxholo, kunye nazo zonke izisemthethweni ezichasayo ezisetyenziswa kwiphephancwadi.
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