Physiol Behav. I-2012 Jun 6; 106 (3): 332-6. doi: 10.1016 / j.physbeh.2012.03.020.
imvelaphi
IYunivesithi yaseFlorida, ikholeji yezonyango, iSebe lezeengqondo, McK Night Brain Institute, Gainesville FL 32610, United States. [imeyile ikhuselwe]
Abstract
Nangona zibandakanya kuphela isabelo esincinci se-neurons kulo mmandla, ii-interneurons ze-cholinergic kwi-dorsal striatum zibonakala ngathi zidlala indima ebalulekileyo kulawulo lweendlela zokuziphatha ezahlukeneyo, ngokuyinxenye, ngokunxibelelana neenkqubo ze-mesolimbic dopamine (DA). Kolu hlaziyo, sichaza izifundo eziphakamisa ukuba umsebenzi we-cholinergic interneurons kwi-nucleus accumbens (NAc) kunye noqikelelo lwe-cholinergic kwindawo yecandelo le-ventral tegmental (VTA) ichaphazela indlela yokuziphatha yokondla. Kwizifundo ze-vivo ze-microdialysis kwiigundane zityhile ukuba ukupheliswa kwesidlo kunxulunyaniswa nokunyuka kwamanqanaba e-acetylcholine (ACh) kwi-NAc. Ukwenza i-ACh isebenze kuya kuthintela ukondla, kwaye oku kukwayanyaniswa nokonyuka kokuqokelelwa kwe-synaptic ye-ACh. Ukongeza, sixoxa ngendlela, ukongeza kwindima yabo ekupheliseni isidlo, ii-cholinergic interneurons kwi-NAc zidlala indima ebalulekileyo ekuphelisweni kokusetyenziswa kweziyobisi. Enye inkqubo ye-cholinergic ebandakanyeka kwimicimbi eyahlukeneyo yokuziphatha okungafunekiyo yingqikelelo evela kwi-pedunculpontine nuclei ngqo kwi-VTA. Ukwenza kusebenze kwale nkqubo kuphucula indlela yokuziphatha ngokusebenzisa inkqubo ye-mesolimbic ye-DA, kunye nokuchasana kwe-ACh receptors kwi-VTA kunokunciphisa ukuzilawula ngokwamachiza. Okokugqibela, sixoxa ngendima yokuqokelela i-ACh kuzo zombini iziyobisi kunye nokutya okunencasa. Izifundo zityhila ukuba i-accumbens ACh iyanda ngexesha lokurhoxa kumachiza ohlukeneyo okuphathwa gadalala (kubandakanya icocaine, nicotine kunye ne morphine). Oku kunyuka kwamanqanaba angaphezulu kweeseli ze-ACh, kudityaniswa nokwehla kwamanqanaba angaphandle kwe-DA, kukholelwa ukuba kuya kuba negalelo kwimeko ephikisayo, enokubonakalisa njengeendlela zokuziphatha ezinxulumene nokurhoxa kweziyobisi. Le ithiyori ikwasetyenzisiwe kwizifundo zokutya kakhulu kunye / okanye "umlutha wokutya," kwaye iziphumo zibonisa ukungalingani okufanayo kumanqanaba e-DA / ACh, enxulunyaniswa neendlela zokuziphatha zokurhoxa okufana neziyobisi. Isishwankathelo, ii-cholinergic neurons zidlala indima ebalulekileyo kwimodyuli yokutya kunye nokutya iziyobisi, kunye nemiba ephindayo yokutya- kunye nokuziphatha okunxulumene neziyobisi.
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