Neuropharmacology. 2015 Sep 21;101:154-164. doi: 10.1016/j.neuropharm.2015.09.023.
I-LN yemveliso1, Ibala PW1, Icasey GR2, I-webb ye-IC2, Coolen LM3.
Abstract
Amava ezesondo kwiigundane zesilisa ezilandelwa lixesha lokuyekiswa kubangela uvakalelo kumvuzo we-d-Amphetamine (Amph), oboniswa kukonyuka kokhetho kwindawo (CPP) yemithamo ephantsi yeAmph.. Ngaphaya koko, amava ezesondo afaka i-neural plasticity ngaphakathi kwe-nucleus accumbens (NAc), kubandakanywa ukwenziwa kwe-deltaFosB, edlala indima ephambili kumnqweno wokufumana u-Amph.
I-NMDA receptor subunit i-NR1 iphinda ikhuliswe ngokuvuthwa, kodwa ukusebenza kwe-NMDA receptors kumava esini-iziphumo ezithandwayo azaziwa.
Apha, sivavanye impembelelo ye-infra-NAc MK 801 infusions kumava ezesondo-afaka i-NAc deltaFosB kunye nenkcazo ye-cFos, kunye nokutsala- kunye ne-Amph-indened CPP kwimigca yamadoda amadala.
Kwilingo le-1, amadoda afumana i-MK 801 okanye i-saline kwi-NAc ngexesha ngalinye le-4 leentsuku zokulandelelana nokuzilungisa kwaye kwavavanywa i-Amph CPP kunye namava okuphelisa i-deltaFosB 10 kwiintsuku kamva.
I-Intra-NAc MK 801 ngexesha lokuziphatha ngokwesondo ithintele ukunyuka kwamava kwi-Amph CPP kunye ne-NAc deltaFosB expression ngaphandle kokuchaphazela indlela yokuziphatha ngokwesondo.
Kwilingo le-2, iziphumo ze-intra-NAc MK 801 kwi-CPP-in-induction-in-matension zavavanywa ngokunyanzelwa kwe-intra-NAc kweMK 801 okanye i-saline ngaphambi kokutsalwa kwemihla yokuhlengahlengiswa. I-Intra-NAc MK 801 ayichaphazelekanga i-CPP-indved-ikiwa.
Okulandelayo, iimpembelelo ze-intra-NAc MK 801 kwi-cFos yokungeniswa kwi-immunoreactivity ziye zavavanywa. I-MK 801 ithintele ukubonakaliswa kwe-cFos yoku-mating kwi-NAc igobolondo kunye nomongo.
Ngokudibeneyo, ezi ziphumo zibonelela ubungqina bokuba i-NAc NMDA receptor isebenze ngexesha lokuziphatha ngokwesondo idlala indima ebalulekileyo ekuphembeleleni i-cFos kunye neentetho ze-deltaFosB kunye namava alandelayo-okuphembelela ukuwela kumnqamlezo kumvuzo we-Amph.
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