Synapse. 2004 Jul;53(1):20-7.
Bradley KC1, Mullins AJ, Meisel RL, Watts VJ.
Abstract
Iziyobisi zokuxhatshazwa ziveza utshintsho lwexesha elide kwi-dopamine neurotransuction kunye ne-receptor-made intracellular signaling. Iinguqu ezifanayo kwimisebenzi ye-neuronal zixutywe kukuziphatha okukhuthazayo. Ukuphononongwa kweendlela zeselula ezilandela ezi neuroadaptations kulandela amava ezesondo, ukuqokelelwa kwe-cyclic AMP kulandela ukukhuthaza kwe-D1 dopamine receptors, G-protein, kunye ne-cymbase ye-adenylate kuthelekiswa ne-nucleus accumbens kunye ne-caudate ye-nusate ye-hamsters yesini engenamsebenzi kunye namava alandelayo ngokuziphatha ngokwesondo. Ukuvuselelwa ngokuthe ngqo kwe-adenylate cyclase nge-forskolin okanye ngokungathanga ngqo ngokusebenza kwe-G-protein ene-Gpp (NH) p ivelise idosi-exhomekeke kwinkuthazo ekwakhiweni kwe-cyclic AMP kwi-nucleus accumbens kunye ne-caudate nucleus, ngaphandle kweziphumo zesondo kumava. Ukunyuswa okukhethekileyo kwe-D1 ye-receptor yokunyusa amandla e-Gpp (NH) p-inkuthazo ye-adenylate cyclase yomsebenzi kwi-nucleus accumbens kunye ne-caudate nucleus yazo zonke izilwanyana. Okubangela umdla kukuba, oku kukhuthazeka kuphuculwe ngakumbi kwi-membranes evela kwi-nucleus accumbens, kodwa hayi ukusuka kwi-caudate nucleus, yama-hamsters anamava ngokwesondo xa kuthelekiswa nokuphendula kwabasetyhini abangafundanga. Ezi ziphumo zibonisa ukuba amava okuziphatha ngokwesondo anokubangela uvakalelo lwe-mesolimbic dopamine kwaye nokuba le mvakalelo yenzeka ngokwanda kwe-D1 receptor-mediated signaling.
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