Neuroreport. 2020 Feb 5; 31 (3): 240-244. doi: 10.1097 / WNR.0000000000001400.
USalaya-Velazquez NF1, ILopez-Muciño LA1, UMejía-Chávez S1, ISánchez-Aparicio P2, IDomínguez-Guadarrama AA3, IVenbra-Muñoz A1.
Abstract
Umvuzo wokutya ufundwe ngesimo esithandekayo esivela kwizongezelelo zendalo ezinje nge-sucrose. Esona songezo sokutya siqhelekileyo yi-sucralose, isisongelo se-noncaloric ekhoyo kwiimveliso zokutya ezininzi zemihla ngemihla. Indima ye-anandamide [N-arachidonylethanolamide (AEA)], cannabinoid endo native, ifundwe ngokubanzi kwindlela yokuziphatha yokutya. Izifundo zibonakalise ukuba i-cannabinoids, ezinje nge-AEA, 2-Arachidonilglycerol, kunye neTetrahydrocannabinol, zinokuvuselela i-hyperphagia, kuba zonyusa ukuthanda kunye nokutya okumnandi kunye namafutha aphezulu. Umbono wokungcamla uxolelaniswe nodidi lwencasa ye-receptor 1 receptor 3 (T1R3); ke ngoko, kunokubakho isylinggistic effect phakathi kwee-receptors ze-CB1 kunye ne-T1R3. Oku kunokucacisa ukuba kutheni i-cannabinoids inokutshintsha ukunambitheka okumnandi kwaye ke umsebenzi we-neural nuclei obandakanyeka kumngcipheko kunye nomvuzo. Kolu phononongo, sivavanye umsebenzi we-dopaminergic nuclei obonakalayo kumvuzo wokutya emva kokulawulwa okungapheliyo kwe-AEA (0.5 mg / kg bw) kunye nokutya kwe-sucralose (0.02%). Sihlalutye intetho ye-ΔFosB ngu-immunohistochemistry. Iziphumo zethu zibonisa ukuba ulawulo olungapheliyo lwe-AEA kunye nokutya kwe-sucralose kuzisa i-overexpression ye-ΔFosB kwindawo ye-infralimbic cortex (Cx), i-nucleus accumbens (NAc) isembindini, igobolondo, kunye nentloko ye-amygdala (Amy). Ezi ziphumo zibonisa ukuba ukusebenzisana okunokwenzeka phakathi kwe-receptors i-CB1 kunye ne-T1R3 kuneziphumo kungekuko kumbono wokunambitha kuphela kodwa nokuba i-AEA ingenelela emsebenzini we-dopaminergic nuclei efana ne-NAc, kunye nolawulo olungapheliyo lwe-AEA kunye nokuthatha ixesha elide kwi-sucralose. Inkqubo yomvuzo.
PMID: 31923023
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