Neuropsychopharmacology. 2016 Mar 16. doi: 10.1038 / npp.2016.39.
Isingqala BF1, UBubula N2, Li D2, IPrzybycien-Szymanska MM2, IBindokas VP3, UVezina P1,2.
Abstract
Ukubonakaliswa okuphindaphindiweyo kwi-amphetamine kukhokelela kuzo zombini iimeko zokunxibelelana kunye nokuziva okungahambelani. Apha sivavanye igalelo lama-envirles e-neuronal kwi-nucleus accumbens (NAcc) kwezi ndlela zokuziphatha. Izilwanyana ezivezwe kwi-amphetamine IP okanye kwindawo yecandelo le-venral tegmental (VTA) zabonisa impendulo ye-locomotor evakalayo xa iphikiswa ne-amphetamine iiveki kamva. Zombini iindlela zokuvezwa kukonyusa amanqanaba ΔFosB kwi-NAcc. Olunye uphawu lwezi ΔFosB + zee-neurons, nangona kunjalo, luveze ukuba i-amphetamine ayinampembelelo kwi-dendritic spine density okanye ubungakanani, ibonisa ukuba ezi neurons azenzi lutshintsho kwi-dendritic spine morphology ehamba kunye nokuvakaliswa kovakalelo olungahambelani. Uvavanyo olongeziweyo oluchaze indlela i-neurons kwi-NAcc enegalelo ngayo ekubonakalisweni kwemeko yokudibana. Inkqubo yokufunda yocalucalulo yayisetyenziselwa ukubhentsisa iigundane kwi-IP okanye i-VTA amphetamine nokuba ibunziwe okanye engafakwanga ngenkundla evulekileyo. Njengoko kulindelwe, kuthelekiswa neKulawulo, iigundane ezibini ezilawulwa i-amphetamine ye-IP emva koko yabonisa ukuphendulwa komgangatho we-locomotor xa icelomngeni ne-saline kwindawo evulekileyo, isiphumo esilandelwa kukonyuka kwe-c-Fos + neurons kwi-medco NAcc. Olunye uphawu lwale seli ze-c-Fos + luveze ukuba iigundane ezibhangqisiweyo zibonisa ukonyuka koxinano lwe-dendritic spine kunye nobungakanani beepine eziphakathi nendawo kwi-NAcc. Ngokuchasene noko, iigundane ezihanjiweyo ngaphambili ezazivezwe kwiVTA amphetamine azibonisanga ndawo yendawo okanye imeko ye-c-Fos + ayikho. Ngokudibeneyo, ezi ziphumo zicebisa indima ye-c-Fos + neurons kwi-medical NAcc kunye notshintsho olukhawulezileyo kwi-morphology ye-dendritic spines kwimo yokubonakalisa imeko evuswe yi-amphetamine-paired stimuli.
PMID: 26979294
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