Prog Neuropsychopharmacol Biol Psychiatry. I-2016 Dec 3; 74: 15-30. doi: 10.1016 / j.pnpbp.2016.11.008.
UWille-Bille A1, de Olmos S1, Marengo L2, I-Chiner F2, I-Pautassi RM3.
Abstract
Ukusetyenziswa kwangoko kwe-ethanol kuqikelela ukukhula kwexesha lokuphazamiseka ekusebenziseni utywala. Umahluko onxulumene nobudala ekusetyenzisweni kwakhona kwiziphumo ze-ethanol kunokuba phantsi kwesi siphumo. Iigundane zokufikisa zinobuntununtunu kwaye zinobuntununtunu obuncinci kunabantu abadala kwizimvo zokuziphatha ezinxaxhileyo kunye neendlela zokuziphatha ezinxamnye ne-ethanol, ngokwahlukeneyo, kunye nokuziva ngakumbi kwiziphumo ze-neurotoxic zokuvavanywa kolawulo lwe-binge ye-ethanol. Nangona kunjalo, kuncinci okwaziwayo malunga nokungafani okunxulumene nobudala kwiziphumo ze-neural ze-ethanol ezilawulwa nguwe. I-osBFosB yinto ekhutshelweyo eqokelelwa emva kokuvezwa gwenxa kweziyobisi kwaye isebenza njengophawu lweemolekyuli zeplastiki ye-neural ehambelana notshintsho lube likhoboka. Sivavanye iimpembelelo ezingapheliyo (Iiseshini ze-18 zokukhetha ukutya kwiibhotile ezimbini zisasazeke kwiintsuku ezingama-42, ubude beseshoni: 18h) i-ethanol [okanye kuphela isithuthi (iqela lolawulo)] ukuzilawula ngexesha lokufikisa okanye ukuba mdala ekufakweni kwe-ΔFosB kwiindawo ezininzi zobuchopho, Ukuziphatha okufana noxinzelelo, kunye nomsebenzi we-ethanol-induction locomotor kunye nendawo ekhethiweyo yokukhetha (CPP) kwiigundane zaseWistar. Iigundane zokufikisa zibonise ukukhula okuqhubekayo kokutya kwe-ethanol kunye nokukhetha, ngelixa iigundane zabantu abadala zibonisa imodeli ezinzileyo yokungenisa. Bambalwa umahluko wokuziphatha ebaleni elivulekileyo okanye kuvavanyo olumnyama ukukhanya kwaqwalaselwa emva kovavanyo lokutya. Ngaphaya koko, ulawulo lwe-ethanol aluzange lukhuthaze ukubonakaliswa kwe-CPP ye-ethanol. Kwakukho, nangona kunjalo, umahluko omkhulu onxulumene nobudala kwiziphumo ze-neural zokusela i-ethanol: inani elikhulu kakhulu leeseli ze-ethanol ezibangelwa yi-ΔFosB zafunyanwa kulutsha ngokuchasene nabantu abadala kwi-prelimbic cortex, dorsolateral striatum, nucleus accumbens core and shell , kunye ne-amygdala nucleus capsular kunye ne-basolateral amygdala, neyantlukwano enxulumene nesondo efumaneka kumbindi we-amygdala. Oku kubangelwa kukungeniswa kwe-ΔFosB kwi-ethanol kunokubonisa omnye umahluko onxulumene nobudala kuvakalelo kwi-ethanol enokuthi ibeke abakwishumi elivisayo emngciphekweni omkhulu wokusetyenziswa kwengxaki ye-ethanol.
IINKCUKACHA: Ulutsha; Abantu abadala; Ukusela i-Ethanol; Umsebenzi we-encomotor we-ethanol I-FBB
PMID: 27919738
DOI: I-10.1016 / j.pnpbp.2016.11.008
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