Physiol Behav. 2015 Apr 18;147:102-116. doi: 10.1016 / j.physbeh.2015.04.029.
Shannonhouse JL1, I-Grater DM2, York D2, Wellman PJ3, Morgan C4.
Abstract
Abasetyhini kunokwenzeka ngakumbi kunamadoda ukubonisa ukuphazamiseka okunyanzelekileyo (umzekelo, i-anhedonia kunye noxinzelelo) ngeendlela zokonyango ezinqongopheleyo, kunye nokutya ngaphezulu okunamafutha aphezulu "ukutya okuthuthuzelayo" ukuphucula ukuphazamiseka okukhuthazayo. Ngelishwa, ukuxhaswa kwe-neurobiological yokwahluka ngokwesini kuphazamiso olushukumisayo kunye neempendulo zabo kumanqatha okutya akuqondwa kakuhle. Ukunceda ukuvala ezi zikhewu zisisiseko zolwazi, sivavanye indlela yokuziphatha kunye neempendulo ze-neurobiological kumanqatha okutya kwimodeli ye-hamster ye-lability-biased motivational lability. Inxulumene nezindlu zentlalo, ukwahlulwa ekuhlaleni kunciphise i-hedonic drive kwindlela entsha yokuziphatha, uvavanyo lokukhetha ukhetho lomvuzo (RIP). I-Fluoxetine okanye unyango lwe-desipramine lwe-21, kodwa hayi i-7, iintsuku eziphuculweyo ukusebenza kovavanyo lwe-RIP. Ukucaciswa kwe-Pharmacologic kolu vavanyo kuboniswe ngokungaphenduli kwi-diazepam, tracazolate, propranolol, okanye naltrexone. Kuvavanyo olunxulumene noxinzelelo / uvavanyo lwempixano olunxulumene noxinzelelo (i-AFEC), ukwahlukana kwezentlalo kwenza mandundu ukutya ukutya okumnandi kakhulu phantsi kweemeko zoxinzelelo, kodwa hayi kwiikheji zasekhaya. Ukwahlula ngokwasentlalweni kukwehlisile ukutyeba kobunzima, ukutya ukutya, kunye nokuthambeka ngelixa kuphakanyiswa inkcitho yamandla, kuvavanywa ukusebenza kweekhalori kunye nekhalori engangqalanga. Ngaphaya koko, ukutya okungapheliyo okunamafutha aphezulu kuphuculwe iimpendulo ze-anhedonic kunye nexhala lokwahlukana, ngakumbi kwabasetyhini. Kwizinto eziphembelela inkuthazo ye-nucleus eqokeleleneyo, abantu ababhinqileyo, kodwa ingengabo abesilisa, babonisa ukwehla okuhambelana nokwehla okunxulumene noxinzelelo kumanqanaba eCreb1 mRNA kunye nokwehla okunxulumene ne-anhedonia kumanqanaba e-osFosb mRNA. Iyahambelana ne-antidepressant- kunye ne-anxiolytic-efana nefuthe lokuziphatha, ukutya okunamafutha aphezulu kunyusa i-Creb1 kunye ne-osFosb mRNA kumanqanaba abantu ababhinqileyo kuphela. Olunye uphawu lokufumana umvuzo, i-Tlr4 mRNA, yaphakanyiswa kwabasetyhini ngokutya okunamafutha aphezulu. Ezi ziphumo zibonisa ukuba ukwahlulwa kwentlalo kwee-hamsters kubonelela ngemodeli yenoveli ye-comorbid anhedonia exhomekeke kwisini, ixhala, kunye ne-anorexia, kunye ne-CREB ye-accumbal, ΔFosB, kunye ne-TLR4. Ngaphaya koko, iziphumo ziyaqinisekisa ulingo olutsha ngokusebenza okungapheliyo koxinzelelo.
Ilungelo lokushicilela X XUMUM Elsevier Inc.
IINKCUKACHA:
Anhedonia; I-Anorexia; Uxinzelelo lwe-antidepressant; Ixhala; Anxiolytic
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