Umlutha weBool. I-2015 Nov 24. doi: 10.1111 / adb.12330.
UGao P1, I-Limpens JH2, Spijker S3, IVanderschuren LJ2,4, UVoorn P1.
Abstract
Utshintsho olusuka kwinto eqhelekileyo ukuya ekusebenziseni ngokunyanzelekileyo ukusetyenziswa kweziyobisi lucingelwa ukuba lwenzeka njengesiphumo sokuthatha iziyobisi okuphindaphindiweyo okukhokelela kutshintsho lwe-neuroadaptive ekujikelezeni kwengqondo okubandakanyeka kwimvakalelo nasekwazini. Kwisiseko se-neuroadaptations ezilele iinguqu ekubonakalisweni kwe-genes kwangoko (IEGs) yokunyanzeliswa kommiselo wokukhuphela, i-synaptic plasticity kunye ne-intracellular signaling. Nangona kunjalo, kuncinci okwaziwayo malunga nendlela iipateni zokubonisa ze-IEG zitshintsha ngexesha lokulawula iziyobisi ixesha elide.
TUhambisa isifundo, ke, uthelekisa imiphumo ye-10 kunye ne-60 yemini yokuzilawula kwe-cocaine kunye ne-sucrose kwi-expression ye-17 IEGs kwimimandla yobuchopho ifakwa kwisenzo somlutha, okt dorsal striatum, stralatum ye-ventral kunye ne-medial preortal cortex (mPFC).
Ukunyuka kokuthetha emva kokulawulwa kwe-cocaine kufunyenwe kwi-6 IEGs kwi-dorsal kunye ne-ventral striatum (c-fos, Mkp1, Fosb / ΔFosb, Egr2, Egr4, and Arc) kunye ne-10 IEGs kwi-MPFC (efanayo ye-6 IEGs. , I-Homer1, Sgk1 kunye ne-Rgs2). Ezintlanu kwezi 10 IEGs (Egr2, Fosb / ΔFosb, Bdnf, Homer1 kunye neJun) kunye neTrkb kwi-mPFC zaziphendula kulawulo lwe-sucrose lwexesha elide.
Ngokubalulekileyo, akukho mahluko omkhulu wafunyanwa phakathi kweendlela zokubonisa ze-IEG emva kweentsuku ze-10 okanye ze-60 zokuzilawula kwe-cocaine, ngaphandle kweFosb / ΔFosb kwi-dorsal striatum kunye ne-Egr2 kwi-mPFC, kanti inani lecocaine efunyenwe ngeseshoni nganye yayithelekiswa nolawulo lwexesha elide kunye nolawulo lwexesha elide.
Olu tshintsho luzinzileyo ekubonakalisweni kwe-IEG, ke ngoko, lunxulumene nokuziphatha okuzinzileyo kokuzilawula kunokuba lilonke inani lecocaine elichithekileyo. Ke ngoko, ukuthintela okuzinzileyo kummiselo we-IEG ngexesha lolawulo lwecocaine ixesha elide kunokuvuselela utshintsho lwe-neuroplastic ngokunyanzelwa kokusetyenziswa kweziyobisi.
IINKCUKACHA: Ukuzilawula kwecocaine; dorsal striatum; Uhlobo lwangoko i-cortex yangaphambili; I-ventral striatum
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