Am J Ukusetyenziswa Kakubi kotywala. 2019;45(1):84-89. doi: 10.1080/00952990.2018.1529182.
Sadat-Shirazi MS1,2, Babhadi-Ashar N1, Khalifeh S3, Mahboubi S2, Ahmadian-Moghaddam H1, Zarrindast MR1,4,5.
Abstract
UMGQUBO:
Ngaphandle kwesiphumo se-analgesic ye-tramadol, ukuvezwa ixesha elide kwi-tramadol kunokubangela utshintsho oluguqukayo ngaloo ndlela lukhokelela kukuxhomekeka kunye nokunyamezelana. I-Tramadol yenza umphumo wayo ngokusebenzisa i-µ-opioid receptor (MOR). Nangona kunjalo, i-tramadol inezinye iithagethi ezifana ne-serotonin kunye ne-epinephrine transporters.
INJONGO:
I-CREB kunye ne-ΔFosB zizinto ezikhutshelweyo, ezibandakanyekayo ekuziphatheni okungaqhelekanga okusisiseko sokusetyenziswa gwenxa kweziyobisi. Kolu phononongo, iziphumo zonyango lwe-tramadol olubukhali kunye nolungapheliyo kumanqanaba e-MOR, ΔFosB, kunye ne-CREB zafundwa.
IINDLELA:
Ukwenzela le njongo, kwasetyenziswa iimpuku zeWistar ezingamadoda angama-36. Izilwanyana zahlulwa zangamaqela amabini aphambili. Izilwanyana ze-18 zizonke zifumene i-tramadol (0, 5, kunye ne-10 mg / kg) ngokukhawuleza kwaye izilwanyana ze-18 zafumana amanani afanayo kwiintsuku ze-14 ezilandelayo. Iyure enye emva kwesitofu sokugqibela, i-NAC kunye ne-PFC yachithwa kwaye igcinwe kwi -80 ° C kwi-nitrogen engamanzi. Kusetyenziswa ubuchule bokubhula entshona, amanqanaba e-MOR, ΔFosB, kunye ne-p-CREB avavanywa.
IINKCUKACHA:
Kwi-NAC, i-acute tramadol exposure yonyusa amanqanaba e-MOR kunye ne-p-CREB. Ngapha koko, ulawulo lwetramadol olungapheliyo kulo mmandla lukhokelela kumanqanaba aphezulu e-MOR, ΔFosB kunye ne-p-CREB xa kuthelekiswa neempuku eziphathwe ngetyuwa. Amanqanaba e-MOR kunye ne-p-CREB kwi-PFC ande kwi-exposure ebukhali kunye nengapheliyo ye-tramadol. Kwakhona, amanqanaba e-ΔFosB anyuke kuphela emva kolawulo olungapheliyo lwe-tramadol. Iziphumo zibonise ukuba utshintsho oluziqhelanisayo lwenzekile ngexesha lokuvezwa ngamachiza.
UKUQINISWA:
Sigqibe kwelokuba zombini i-CREB kunye ne-ΔFosB zidlale indima ekuxhomekeke kwi-tramadol. Ukongeza, ukonyuka kwamanqanaba e-MOR ngexesha lonyango lwe-tramadol kunokuba ngenxa ye-receptors deensitization.
AMAGAMA ENGUNDOQO: CREB; Tramadol; i-nucleus accumbens; i-cortex yangaphambili; µ-i-opioid receptor; ΔFosB
PMID: 30632799
INGXELO: 10.1080 / 00952990.2018.1529182
;