Semin Nucl Med. 2017 Jan;47(1):64-74. doi: 10.1053/j.semnuclmed.2016.09.003.
Trifilief P1, UDucrocq F2, van der Veldt S3, UMartinez D4.
Abstract
I-Positron emission tomography (PET) imaging ihlala ibonisa ukukhutshwa kwe-striatal striatal dopamine kunye nokuncipha kokufumaneka kwe-dopamine D2 receptor kubukhoboka. Apha, siphonononga izifundo zangaphambi kweklinikhi kunye nezonyango ezibonisa ukuba le phenotype ye-neurobiological kusenokwenzeka ukuba ibe sisiphumo sokusetyenziswa kweziyobisi ezingapheliyo kunye nento esichengeni ekuphuhliseni umlutha. Sicebisa ukuba, ngokuziphatha, ukuhanjiswa kwe-striatal striatal striatal kungabonakalisa ukonyuka kokutsaleka kunye nokuguqulwa kweendleko / ukubalwa kwenzuzo ezinxulumene nokukhobokisa. Izinto eziphembelela ukuhanjiswa kwe-striatal dopamine kwiziyobisi azaziwa. Apha, sinika isishwankathelo sezinto ezahlukeneyo, imfuzo, indalo, kunye nentlalo, ezaziwa ngokuchaphazela usasazo lwe-dopamine kwaye zayanyaniswa nokuba sesichengeni sokuphuhlisa umlutha. Lilonke, ezi datha zibonisa ukuba ukuhanjiswa kwe-dopamine blunted kunye nokuncipha kokufumaneka kwe-D2 receptor ziimpawu zebhayoloji zombini kuphuhliso lokulutha kunye nokuchasana nonyango. Ezi ziphumo zixhasa umbono wokuba i-dopamine ebumnyameni ibonisa indlela yokuziphatha engxamisekileyo kunye nokusilela kwinkuthazo, ekhokelela ekwenyukeni kokusetyenziswa kweziyobisi.
PMID: 27987559
DOI: 10.1053/j.semnuclmed.2016.09.003
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