Kay M. Tye, UJulie J. Mirzabekov, Melissa R. Warden, Emily A. Ferenczi, Hsing-Chen Tsai, UJoel Finkelstein, Sung-Yon Kim, Avishek Adhikari, Kimberly R. Thompson, Aaron S. Andalman, ULisa A. Gunaydin, Ilana B. Witten & Karl Deisseroth
Indalo (2012)doi:10.1038/indalo11740
- I funyenwe 02 May 2012
Ukudakumba okukhulu kubonakala ngeempawu ezahlukahlukeneyo eziphazamisayo ezibandakanya ukungabi nathemba kunye ne-anhedonia1. I-Dopamine neurons ebandakanyeka kumvuzo kunye nenkuthazo2, 3, 4, 5, 6, 7, 8, 9 ziphakathi kwabemi abaninzi be-neural ekucingelwa ukuba bafanelekile10, kunye nonyango oluthile lwe-antidepressant, kubandakanywa amayeza kunye nonyango lokuvuselela ingqondo, lunokuba nefuthe kwinkqubo ye-dopamine enzima. Ukuza kuthi ga ngoku akukenzeki ukuvavanya le ngcamango ngokuthe ngqo, nakwimodeli yezilwanyana, njengoko ungenelelo lonyango olukhoyo alukwazi ukujolisa ngokuthe ngqo kwi-dopamine neurons. Apha siphande ngokuthe ngqo igalelo le-causal ye-dopamine neurons echaziweyo kwi-multidimensional depression-efana ne-phenotypes ebangelwa luxinzelelo oluthambileyo olungapheliyo, ngokudibanisa iindlela zokuziphatha, ze-pharmacological, i-optogenetic kunye ne-electrophysiological kwiimpuku ezihamba ngokukhululekileyo. Sifumene ukuba ulawulo lwe-bidirectional (inhibition okanye uchulumanco) lwe-midbrain dopamine neurons ekhankanyiweyo ngokukhawuleza kwaye imodareyitha ngokuphindwe kabini (ibangela okanye ikhulule) iimpawu ezininzi zokudakumba ezizimeleyo ezibangelwa luxinzelelo olungapheliyo. Ngokuphonononga ukuphunyezwa kwesekethe kwezi ziphumo, siye sabona ukuba ukuqeshwa kwe-optogenetic kwezi dopamine neurons kutshintsha ngokubonakalayo i-neural encoding yeendlela zokuziphatha ezinxulumene nokudakumba kwi-nucleus esezantsi eqokelela amagundane ahamba ngokukhululekileyo, ecebisa ukuba iinkqubo ezichaphazela iimpawu zokudakumba zinokubandakanya utshintsho kwi-neural. ukufakwa kweekhowudi kwintshukumo yelimbic.
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