I-Risperidone yi-dopamine antagonist, oko kuthetha ukuba kunciphisa ukubopha kwe-dopamine kwii-dopamine receptors. Njengabanye abachasene ne-dopamine, i-risperidone iqalise uxinzelelo lwentlalo kwabanye abasebenzisi.
I-Neurology. I-2003 Aprili 8; 60 (7): 1130-5.
I-Scahill L, i-Leckman JF, Schultz RT, Katsovich L, Peterson BS.
imvelaphi
IZiko leMfundo lokuFunda, iSikolo saBongikazi, iYunivesithi yaseYale, iNew Haven, i-CT 06520, e-USA. [imeyile ikhuselwe]
Abstract
INJONGO:
Ukuvavanya ukusebenza ngokukhuselekileyo kunye nokukhuseleka kwe-risperidone kubantwana nakubantu abadala abaneTourette syndrome.
IINDLELA:
Le yayiyiveki ye-8-veki, yenziwa ngokungakhethiyo, iimfama ezimbini, zilawulwa nge-placebo. Owona mqobo wesiphumo sasiyi-Tic yenqaku le-Yale Global Tic Severity Scale (YGTSS).
IINKCUKACHA:
Izifundo ezingasimahla zamayeza ezingamashumi amathathu anesine (abantwana be-26 kunye nabantu abadala be-8) ukusukela kwiminyaka yobudala be-6 ukuya kwi-62 iminyaka (kuthetha = 19.7 +/- 17.0 iminyaka) ethathe inxaxheba. Amanqaku e-YGTSS apheleleyo e-Tic afanayo kwisiseko (i-26.0 +/- 5.1 ye-risperidone vs 27.4 +/- 8.5 ye-placebo). Emva kweeveki ze-8 zonyango (kuthetha ukuba idosi yemihla ngemihla ye-2.5 +/- 0.85), izifundo ze-16 ezikwi-risperidone zibonisa ukunciphisa kwe-32% ekunciphiseni kobunzima besiseko, kuthelekiswa nokucuthwa kwe-7% kwizigulana ze-placebo (n = 18) (F [ 2,64] = 6.07; p = 0.004). Abantwana be-12 abakhethwe ngokungafanelekanga kwi-risperidone babonisa ukunciphisa kwe-36% kwiimpawu ze-tic xa kuthelekiswa nokuncipha kwe-11% kubantwana be-14 kwi-placebo (F [2,48] = 6.38; p = 0.004). Ababini abantwana kwi-risperidone babonakalisa ubukho bentlalo obusisigxina, obasombulula ngokuncitshiswa kwedosi kwisifundo esinye kodwa kwakhokelela ekuyekisweni kwamayeza kwelinye. Ukonyuka okunesisindo somzimba we-2.8 kg kwaqwalaselwa kwiqela le-risperidone ngokuthelekiswa notshintsho kwi-placebo (F [2,64] = 10.68; p = 0.0001). Akukho zimpawu ze-extrapyramidal kwaye akukho lutshintsho lubalulekileyo lweklinikhi ngexesha lokuqhutywa kwentliziyo okanye amanyathelo elabhoratri abonwa.
UKUQINISWA:
I-Risperidone ibonakala ikhuselekile kwaye iyasebenza kunyango lwexesha elifutshane leetics ebantwaneni okanye kubantu abadala abaneTourette syndrome. Izifundo zexesha elide ziyafuneka ukuvavanya ukuqina kokusebenza ngempumelelo kunye nokhuseleko ekuhambeni kwexesha.
;