Berry, uAnne, UC Berkeley
UBerry, uAnne, UC Berkeley, https://orcid.org/0000-0002-5086-3643
[imeyile ikhuselwe], [imeyile ikhuselwe]
Umhla wokupapashwa: NgoSeptemba 5, 2018
Umshicileli: UC Berkeley
https://doi.org/10.6078/D1JM3K
Citation
uBerry, uAnne; UBerry, u-Anne (2018), iindlela ze-Dopaminergic eziphantsi kokwahluka okuqhelekileyo kwinkxalabo yeempawu: ezongezelelweyo, i-UC Berkeley Dash, i-Dataset, https://doi.org/10.6078/D1JM3K
Abstract
Ukuxhalaba kweempawu kuye kwanxulunyaniswa nomsebenzi otshintshileyo ngaphakathi kwendlela ye-corticolimbic edibanisa i-amygdala kunye ne-rostral yangaphambili ye-cingulate cortex (rACC), efumana igalelo elicebileyo le-dopaminergic. Nangona inkcubeko edumileyo isebenzisa igama elithi "ukungalingani kweekhemikhali" ukuchaza i-pathophysiology yeemeko zengqondo ezifana nokuphazamiseka kokuxhalaba, siyazi kancinci malunga nokuba iyantlukwano yomntu ngamnye kwi-dopamine neurochemistry enxulumene nokwahluka kwixhala kunye nomsebenzi ngaphakathi kweesekethe ze-corticolimbic. Siwusombulule lo mbandela ngokuphonononga ukwahluka komntu ngamnye ekukhululweni kwe-dopamine ekuphumleni kusetyenziswa [11C] i-raclopride PET, uqhagamshelwano olusebenzayo phakathi kwe-amygdala kunye ne-rACC usebenzisa i-fMRI yokuphumla, kunye nemilinganiselo yokuxhalaba kubantu abadala abanempilo. Sifumene ubudlelwane obungalunganga phakathi kokukhutshwa kwe-dopamine kunye nokuxhalaba kweempawu ezifana nokuba abantu abane-dopamine ephezulu bakhululwe kwi-amygdala kunye ne-RACC yokuzixela ngokwazo ixhala elisezantsi. Ukuxhalaba kweempawu ezisezantsi kwanxulunyaniswa nokuncitshiswa kwe-rACC-amygdala yoqhagamshelwano olusebenzayo kwisiseko. Ngaphaya koko, unxibelelwano olusebenzayo lubonise ubudlelwane obuphakathi obungalunganga kunye nokukhululwa kwe-dopamine kangangokuba abantu abanonxibelelwano oluncitshisiweyo lwe-rACC-amygdala babonise amanqanaba aphezulu okukhutshwa kwe-dopamine kule mimandla. Ngokudibeneyo, ezi ziphumo zinegalelo kwiimodeli ze-hypodopaminergic zexhala kunye nokuxhasa ukusetyenziswa kokudibanisa i-fMRI kunye nemilinganiselo ye-PET yomsebenzi we-neurochemical ukuqhubela phambili ukuqonda kwethu iinkqubo ezisisiseko ezichaphazela abantu.
tindlela
Izixhobo ezongezelelweyo zibonelelwe apha, ezibandakanya uhlahlelo lokukhutshwa kwe-dopamine kwi-striatum kunye nobudlelwane kunye noxinzelelo lweempawu. Ukongeza, sibandakanya uhlalutyo lwe-right vs hemisphere dopamine ukukhutshwa kunye nokunxibelelana kwe-funcitonal ye-amygdala kunye ne-rostral yangaphambili ye-cingate cortex.
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