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Abaphandi base-US babethelele phantsi umahluko omtsha kwikhemikhali yengqondo yabantu abanengxaki yokungahoywa kwe-hyperactivity disorder (ADHD).
Bafumene abaguli be-ADHD abanazo iiproteni eziphambili ezibavumela ukuba babe namava omvuzo kunye nenkuthazo.
Uphononongo lweBrookhaven National Laboratory luvela kwiJenali yeAmerican Medical Association.
Kuyathenjwa ukuba inokunceda ekuyilweni kweendlela ezintsha zokulwa le meko.
“Kangangexesha elide bekucingwa ukuba abantwana abane-ADHD benza ngabom ngabom” Andrea Bilbow ADDISS
Uphando lwangaphambili olujonge ubuchopho babantu abane-ADHD lufumanise umahluko kwiindawo ezilawula ukuhoywa kunye nokuxakeka.
Kodwa olu phononongo lubonisa ukuba i-ADHD inempembelelo enkulu kwenye indawo engqondweni.
Umphandi uGqr Nora Volkow uthe: "Oku kusilela kwinkqubo yomvuzo wengqondo kunokunceda ukuchaza iimpawu zeklinikhi ze-ADHD, kubandakanya ukungakhathaleli kunye nokuncipha kwenkuthazo, kunye nokuthambekela kweengxaki ezinjengokusetyenziswa gwenxa kweziyobisi kunye nokutyeba phakathi kwezigulana ze-ADHD."
Abaphandi bathelekisa ukujongwa kwengqondo kwizigulana ezingama-53 zabantu abadala be-ADHD abangazange bafumane unyango kunye nabantu abangama-44 ababengenayo le meko.
Bonke abathathi-nxaxheba baye bahlolwa ngononophelo ukuphelisa izinto ezinokuthi zijike iziphumo.
Indlela yeDopamine
Besebenzisa indlela entsonkothileyo yokuskena ebizwa ngokuba yi-positron emission tomography (PET), abaphandi bagxininise kwindlela ubuchopho babathathi-nxaxheba baphatha ngayo imichiza ye-dopamine, umlawuli ophambili wemood.
Ngokukodwa balinganise amanqanaba eeprotheyini ezimbini-i-dopamine receptors kunye nabathuthi-ngaphandle kokuba i-dopamine ingasebenzi ngokufanelekileyo ukuphembelela imo.
Izigulana ze-ADHD zazinamanqanaba asezantsi azo zombini iiproteni kwiindawo ezimbini zobuchopho ezaziwa ngokuba yi-nucleus accumbens kunye ne-midbrain.
Zombini zenza inxalenye yenkqubo ye-limbic, enoxanduva lweemvakalelo, kunye neemvakalelo ezifana nenkuthazo kunye nomvuzo.
Izigulana ezineempawu ze-ADHD ezichazwe ngakumbi zazinawona manqanaba asezantsi eeprotheyini kwezi ndawo.
"Icebisa ukuba ootitshala kufuneka baqinisekise ukuba imisebenzi yesikolo inomdla kwaye inika umdla, ukuze abantwana abane-ADHD bakhuthazeke ukuba bahlale benomdla." Unjingalwazi uKatya Rubia
UGqr Volkow uthe iziphumo zixhasa ukusetyenziswa kwamayeza avuselelayo ukunyanga i-ADHD ngokunyusa amanqanaba e-dopamine.
Iziphumo zikwaxhasa ithiyori yokuba abantu abane-ADHD banokuthambekela ngakumbi ekusebenziseni kakubi iziyobisi kunye nokutyeba kakhulu kuba bengazi ngokuzama ukubuyisela inkqubo yomvuzo enqongopheleyo.
U-Andrea Bilbow, we-ADHD yesisa ye-ADDISS, uthe uphononongo lunokunceda ukweyisela abantu abathi i-ADHD inxulumene kakhulu nobuzali obubi kunawo nawuphi na umahluko obambekayo wezonyango.
Uthe: “Izinto ezifunyaniswe kolu phando lutsha ziya kuhamba indlela ende ekusincedeni ukuba siqonde ukuboniswa kweempawu kodwa okona kubaluleke ngakumbi kunokunika ootitshala umbono wokuba loluphi ungenelelo ekufuneka lusetyenziswe kwigumbi lokufundela ukuze kuhlaliswe abantwana abane-ADHD. .
“Kangangexesha elide bekukho ingcinga yokuba abantwana abane-ADHD benza ngabom ngabom nto leyo ekhokelele kulawulo olugwenxa yaye ekugqibeleni bagxothwa ngokusisigxina esikolweni.”
Unjingalwazi uKatya Rubia, weLondon's Institute of Psychiatry, uthe: “Olu phononongo luyandisa iimbono zethu. Ibonisa ukuba i-ADHD ayisiyonto ingaqhelekanga kwiinkqubo zokuqwalaselwa kwengqondo, kodwa kunye nokungaqhelekanga kumaziko enkuthazo kunye neemvakalelo.
“Icebisa ukuba abafundisi-ntsapho bafanele baqinisekise ukuba imisebenzi yesikolo ibangela umdla yaye inika umdla, ukuze abantwana abane-ADHD bakhuthazeke ukuba bahlale benomdla.”
ISIFUNDO
LWESIBINI, Septemba 8 (IiNdaba zoSuku lweMpilo) -Imbuyekezo-iintsilelo ezixhasayo ezixelwe kubantu abanengxaki yengqwalasela-intsilelo/i-hyperactivity disorder (ADHD) inokunxulunyaniswa nokuphazamiseka kwendlela yomvuzo we-mesoaccumbens ye-dopamine ebonakaliswa ngokuncipha kweempawu ze-dopamine synaptic ezibonwa kwi-positron emission tomography. (PET) ukucinga kwengqondo, ngokutsho kophando kwi-9 Septemba ye-Journal ye-American Medical Association.
UNora D. Volkow, MD, weZiko leSizwe lokuSetyenziswa gwenxa kweZiyobisi eBethesda, Md., kunye noogxa benza i-PET imaging kwizifundo ze-53 ezine-ADHD ezazingekho kumayeza, kunye nezifundo eziphilileyo ze-44, ukufunda umsebenzi kwingqondo ye-mesoaccumbens dopamine. indlela yokuvuza, ekukholelwa ukuba iyabandakanyeka ekuziphatheni kokukhuthaza imivuzo. Ukubophelela okuthe ngqo kwe-positron emission tomographic radioligands kubathuthi be-dopamine (DAT) balinganiswa kusetyenziswa i- [11C] cocaine kunye ne-D2/D3 receptors.
Abaphandi bafumene ukubopha okuthotyiweyo okuthotyiweyo kuzo zombini iiligand kwimimandla yengqondo esekhohlo ebandakanyeka kwindlela yomvuzo we-dopamine kwizifundo ezine-ADHD. Intsingiselo ye-DAT kwi-nucleus accumbens yayingu-0.63 kwizifundo ze-ADHD kunye ne-0.71 yokulawula, kwaye kwi-midbrain yayiyi-0.09 yezifundo ze-ADHD kunye ne-0.16 yokulawula. Kwi-D2/D3 receptors, i-median kwi-accumbens yezifundo ze-ADHD yayiyi-2.68 kunye ne-2.85 yolawulo, kwaye kwi-midbrain yayiyi-0.18 yezifundo ze-ADHD kunye ne-0.28 yokulawula.
"Ekuqukunjelweni, ezi ziphumo zibonisa ukuncipha kweempawu ze-dopamine synaptic kwi-dopamine umvuzo wendlela ye-midbrain kunye nengingqi eqokelelayo yabathathi-nxaxheba abane-ADHD eyayanyaniswa nemilinganiselo yokuhoya," ababhali babhala.
Uninzi lwababhali bophononongo baxele ukuba bafumana inkxaso yophando kunye neefizi zokucebisa kwiinkampani zamayeza.
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