Qhagamshela kwinqaku - https://medicalxpress.com/news/2019-09-brain-circuit-mood-response-stress.html
Uninzi lwabantu luye lwafumana iimeko zoxinzelelo ezibangela imo ethile kwaye zitshintshe neemvakalelo ezithile ngokutya. Iqela lamanye amazwe elikhokelwe ngabaphandi kwiBaylor College of Medicine lajonga amathuba okuba phakathi kokutya kunye nemozulu kwaye lafumanisa isangqa sobuchwephesha kwiimodeli zegundwane ezinxibelelanisa indawo yokondla kunye neemeko zeengqondo. Ipapashwe kwijenali I-Molecular Psychiatry, ezi ziphumo zinokukunceda ukucacisa okunye okuqapheleyo phakathi kweenguqu kwimozulu kunye nemetabolism kunye nokubonelela ngokubonakalayo kwizisombululo zexesha elizayo kwezi ngxaki ngokujolisa kule sekethe.
"Olu phononongo lwaqalwa ngumbhali wokuqala uGqirha Na Qu, ugqirha wezifo zengqondo wase-Wuhan Mental Health Centre, China, xa wayetyelele i-lab yam," utshilo umbhali ohambelana nolu gqirha u-Yong Xu, unjingalwazi onxulumene nezifo zabantwana kunye ne-biology yeemolekyuli kunye neeseli e Ikholeji yaseBaylor yezoNyango.
UQ, ugqirha wezengqondo oqhuba nokwenza ingqondo esisiseko, wayenomdla wokuphanda ukuba ingaba sasikhona na isiseko somnxeba phakathi konxunguphalo kunye nolunye uphazamiseko lwengqondo kunye notshintsho kwimetabolism, njengokungcungcutheka okanye ukungabi namdla wokutya, uye wabona inamba. yezigulana zakhe.
U-Xu, uQ kunye noogxa babo basebenza kunye imodeli yegundwane yoxinzelelo olubangelwa ngu uxinzelelo olungapheliyo kwaye waqaphela ukuba izilwanyana ezixinzelelweyo zisitya kancinci kwaye zilahlekile. Emva koko, basebenzise inani leendlela zokuvavanya ukuqaphela i-neuronal iisekethe yatshintsha imisebenzi xa imfuyo yayinoxinzelelo.
"Sifumanise ukuba ii-neurom ze-POMC kwi-hypothalamus, eziyimfuneko ekulawuleni ubunzima bomzimba kunye nokuziphatha kokutya, zandisa unxibelelwano lomzimba komnye ummandla wobuchopho onee-dopamine neurons ezininzi ezichaphazeleka kulawulo lwemood," utshilo u-Xu. ngumphandi kwiziko loPhando ngeZondlo labantwana e-USDA / ARS e-Baylor nase-Texas Children's Hospital. Siyazi ukuba ukwehla kwedopamine kunokubangela uxinzelelo. ”
Ukongeza kunxibelelwano oluphakathi kokondliwa kunye nendawo yengqondo, abaphandi bafumanise ukuba xa bekhuthaza uxinzelelo kwiimpuku, ii-neurom ze-POMC zenziwa zasebenza kwaye oku kukhokelela kuthintelo lwee-dopamine neurons. Okubangel 'umdla kukuba, xa abaphandi bethintela umjikelezo we-neuronal oxhumanisa ukondliwa kunye nendawo yomoya, izilwanyana zatya ngaphezulu, zafumana ubunzima kwaye zajongana noxinzelelo oluncinci.
Sifumanise ukuba uhlobo loxinzelelo olungapheliyo lubangele isekethe ye-neuronal eqala kwinani leeseli ezaziwayo ukulawula imetabolism kunye indlela yokutya kwaye iphela liqela lee-neurons ezidume ngolawulo lwemood, ”utshilo uXu. "Uxinzelelo olubangelwe luxinzelelo lweziko lokondla kukhokelele kuthintelo lwee-dopamine ezivelisa ii-neurons kwiziko leemood."
Nangona kufuneka uphando oluninzi, u-Xu, uQ kunye noogxa babo bacebisa ukuba iziphumo zabo zibonelela ngesiseko esitsha sebhayoloji esinokuthi sichaze olunye unxibelelwano phakathi kokutshintsha kwemozulu kunye notshintsho kwimetabolism olubonwe ebantwini, kwaye lunokubonelela ngezisombululo kwixesha elizayo.
"Iziphumo zethu zichaza imeko enye, xa uxinzelelo lunxulunyaniswa nokutya okungenampilo. Kodwa kwezinye iimeko ukudangala Unxulumene nokutya kakhulu. Sinomdla wokuphanda le nhlangano yesibini phakathi ngqondweni kunye nokutya kukuchonga imijikelezo ye-neuronal Ingayichaza impendulo, ”utshilo uXu.
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