Biol Psychiatry. I-2015 Meyi 15; 77 (10): 903-11. doi: 10.1016 / j.biopsych.2014.10.024. Epub 2014 Nov 13.
Saddoris MP1, I-Sugam JA1, IStuber GD2, I-IB ebhaliweyo3, Deisseroth K4, Carelli RM5.
Abstract
UMGQUBO:
Ukwenza ukhetho olufanelekileyo, izinto eziphilayo kufuneka zivavanye iindleko kunye nezibonelelo zeziphumo ezixabisekileyo ezinokubakho, inkqubo eyaziwayo ukubandakanya i-nucleus accumbens (NAc) kunye nokufakwa kwayo kwi-dopaminergic. Nangona kunjalo, okwangoku ayaziwa ukuba ngaba i-dopamine ilandelela ngokushukumisayo utshintsho kwixabiso lomvuzo olindelekileyo kwi-intanethi njengokutshintsha kokukhetha kokuziphatha kwaye ukuba kunjalo, ukuba idityaniswe ngokufanelekileyo ngenxa yamacandelo athile amaxabiso anje ngobukhulu bomvuzo kunye / okanye ukulibazisa ukuqinisa.
IINDLELA:
Iindlela ze-Electrochemical zazisetyenziselwa ukulinganisa ukukhutshwa kwe-subcond NAc dopamine ngexesha lomsebenzi wokuphungula ukulungiswa apho ubungakanani bekulungelelaniswe kodwa ukulibaziseka kwahluka kwiibhloko (n = iigundane ze7). Okulandelayo, ukuvavanya ukuba ingaba le nto iphawula ukuvela kwe-dopamine yayinxulumene ngokufanelekileyo nezinto ezithile zokuziphatha okukhethiweyo, saqesha i-optogenetic yokunyusa i-terminals ye-dopamine kwi-NAc isebenzisa umsebenzi wokunciphisa ukulibaziseka apho ukulibaziseka nobukhulu kwahluka ngokuzimeleyo (n = 23 rats).
IINKCUKACHA:
Amakhehla axela kwangaphambili okhetho olwenziweyo lwasusa ukukhutshwa kwe-dopamine okukuko kukhetho olukhethiweyo lwerati kwaye lwatshintshwa ngamandla njengoko kulibaziseka ukuqiniselwa komvuzo omkhulu. Kwilingo lwesibini, ukuhanjwa kwe-dopamine kwakunxulumene ngokufanelekileyo neempawu zokwenza izigqibo, njengoko ukuphuculwa kokukhutshwa kwe-dopamine ngaphakathi kwe-NAc ngexesha lokubonakaliswa komfanekiso okwandisiweyo kwakwanele ukutshintsha ukhetho olunxulumene nexabiso. Ngokubalulekileyo, olu tshintsho luhamba phakathi koku dopamine ekukhetheni lwalunqunyelwe kwisiseko sokulibaziseka, kodwa hayi esekwe kubukhulu, izigqibo.
IMISEBENZI:
Ezi zinto zifunyanisiweyo zibonisa ukuba i-NAc dopamine ilandelela ukuthoba isaphulelo kwaye imisela indima yesizathu sokutyikitywa kweseti yobuchule obumanyanisiweyo.
I-Copyright © 2015 Umbutho we-Biological Psychiatry. Ipapashwe ngu-Elsevier Inc. Onke amalungelo agciniwe.
;