Iintlobo zeeurosci. 2007 May;30(5):228-35. Epub 2007 Epreli 3.
USurmeier DJ1, Ding J, Usuku M, Wang Z, Shen W.
Abstract
I-Dopamine ibumba iindidi ezininzi zemisebenzi ye-psychomotor. Oku kwenziwa ikakhulu ngokumodareyitha imiqondiso ye-cortical kunye ne-thalamic glutamatergic echaphazela i-principal medium spiny neurons (MSNs) ye-striatum.
Imigca emininzi yobungqina icebisa ukuba i-dopamine D1 receptor signing iphucula ukonwatyiswa kwe-dendritic kunye nokubonakaliswa kwe-glutamatergic kwi-striatonigral MSNs, ngelixa ukubonakaliswa kwe-D2 receptor kusebenzisa isiphumo esichaseneyo kwii-MSN ze-striatopallidal. Uchaso olusebenzayo phakathi kwezi zimbini ziphambili ze-striatal dopamine receptors zinabela kulawulo lwe-synaptic plasticity.
Uphononongo lwakutsha nje, kusetyenziswa iimpuku ze-transgenic apho iiseli ziveza i-D1 kunye ne-D2 receptors, ziye zafumanisa umahluko ongaxatyiswanga phakathi kwee-MSNs ezibumba umqondiso we-glutamatergic kunye nefuthe le-DA kwi-synaptic plasticity. Ezi zifundo zikwabonisile ukuba utshintsho lwexesha elide kuphawu lwe-dopamine luvelisa ukubunjwa okunzulu kunye nohlobo oluthile lweseli yoqhagamshelo kunye nomsebenzi we-corticostriatal.
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