IZIMVO: Iiveki ze-8 zokuzilolonga zonyuse kakhulu i-D2 receptors kwi-meth addicts ephantsi konyango. Oku kuxhasa oku kulandelayo:
- Ukuzilolonga kunokunceda ukubuyisela umva umva we-desensitization nakumakhoboka e-meth.
- Amanqanaba e-D2 receptor awabekwanga kwilitye: imiba yokusingqongileyo.
- Ukusetyenziswa kweMeth kubonakala kubangela ukuhla kwe-D2 receptors. Njengakwi #2 le nto iyayikhaba "ozelwe ukuba likhoboka" meme.
Neuropsychopharmacology. 2015 Okt 27. doi: 10.1038/npp.2015.331.
Robertson CL1,2, Ishibashi K2,3, Chudzynski J3, Mooney LJ3, Rawson RA3, Dolezal BA4, Cooper CB4, Ntsundu AK1,2, I-Mandelkern MA2, London ED1, 2,3.
Abstract
I-Methamphetamine Use Disorder inyanyaniswa nokusilela kwe-striatal dopaminergic, edityaniswe neziphumo zonyango olubi, ukuchonga ezi ntsilelo njengenjongo yonyango ebalulekileyo. Ukuzivocavoca kunciphisa umonakalo we-neurochemical owenziwe yi-methamphetamine kwingqondo yegundane, kwaye uqwalaselo lokuqala lubonisa ukuba umthambo uphakamisa ukufumaneka kwe-receptor ye-striatal D2 / D3 (elinganiswa njenge-non-displaceable binding, BP).ND) kwizigulane ezine-Parkinson's disease.
Injongo yolu phononongo yayikukuvavanya ukuba ingaba ukongeza inkqubo yoqeqesho lokuzilolonga kungenelelo lokuziphatha kwabagulayo ngenxa yokuphazamiseka kokusetyenziswa kwe-methamphetamine kubuyisela ukusilela kwi-striatal D2/D3 receptors. Abathathi-nxaxheba babengamadoda nabasetyhini abadala abaye badibana neendlela ze-DSM-IV zokuxhomekeka kwe-methamphetamine kwaye babhaliswa kwindawo yokuhlala, apho bahlala bengazibandakanyi kwiziyobisi ezingekho mthethweni zokuxhatshazwa kwaye bafumana unyango lokuziphatha ngenxa yokuba likhoboka labo.
Baye bahlelwa ngokungenamkhethe kwiqela elifumene i-1-hr egadwayo yoqeqesho lokuzilolonga (n=10) okanye omnye ofumene uqeqesho lwezempilo-imfundo elinganayo (n = 9), iintsuku ze-3 / iveki kwiiveki ze-8.
Beza kwiziko lophando lwezifundo kwi-positron emission tomography (PET) besebenzisa 18I-F-fallypride ukumisela imiphumo ye-8-iveki yokungenelela kwi-striatal D2 / D3 receptor BPND.
Kwisiseko, i-striatal D2 / D3 BPND awahlukanga phakathi kwamaqela. Nangona kunjalo, emva kweeveki ze-8, abathathi-nxaxheba kwiqela lokuzilolonga babonise ukwanda okukhulu kwi-D2 / D3 BP yokubulala.ND, ngoxa abo bakwiqela lemfundo bengazange. Akukho tshintsho kwi-D2 / D3 BPND kwimimandla engaphandle kwelizwe kulo naliphi na iqela.
Ezi ziphumo zibonisa ukuba uqeqesho lokuzilolonga olucwangcisiweyo lunokuphucula i-striatal D2 / D3 receptor deficits kubasebenzisi be-methamphetamine, kwaye iziqinisekiso zovavanyo olongezelelweyo njengonyango lokuncedisa ukuxhomekeka okuvuselelayo.I-Neuropsychopharmacology eyamkelekileyo inqaku lokujonga kuqala kwi-intanethi, i-27 Oktobha 2015. doi: 10.1038/n.2015.331.
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