Neuroimage. 1997 May;5(4 Pt 1):251-60.
Larisch R, Klimke A, Vosberg H, Loffler S, UGaebel W, UMüller-Gärtner HW.
imvelaphi
Iklinikhi yeNuclear Medicine, iYunivesithi yaseDüsseldorf, eJamani.
Abstract
Inkqubo ye-dopaminergic yinkqubo ye-neurotransmitter yomgqatswa ekucingelwa ukuba ibandakanyeka kwi-pathogenesis yoxinzelelo. Olu phononongo lujongana nomba wokuba ukusebenza kwe-antidepressant ye-serotonin reuptake inhibition inxulumene notshintsho kwinkqubo ye-cerebral dopaminergic. I-cerebral dopamine-D2 receptors ibonakaliswe kwizigulana ze-13 ezinoxinzelelo olukhulu zisebenzisa i-dopamine-D2 receptor antagonist iodobenzamide kunye ne-photon emission tomography enye. Ukubopha i-Dopamine receptor kwavavanywa kabini, ngaphambi nangexesha lokunqanda ukubuyiswa kwakhona kwe-serotonin. Ukonyuka kwe-dopamine-D2 receptor ebophelelayo ngexesha le-serotonin reuptake inhibition yafunyanwa kwi-striatum kunye ne-anterior cingulate gyrus kubaphenduli bonyango, kodwa kungekhona kubantu abangaphenduliyo. Ukonyuka kwe-dopamine-D2 receptor ebophelelayo ihambelana kakhulu nokuchacha kweklinikhi kuxinzelelo njengoko kuhlolwe kunye ne-Hamilton depression scale (r = 0.59 kwi-striatum yasekunene nasekhohlo ngokulandelanayo, P <0.05; r = 0.79 ye-anterior cingulate gyrus, P <0.05 emva Ukulungiswa kweBonferroni). Ulungelelwaniso olufana nolufanelekileyo lwabonwa kwi-precentral gyrus, i-gyrus yangaphambili ye-medial, i-gyrus yangaphambili engaphantsi, kunye nenxalenye engaphambili ye-opercular gyrus, kodwa olu lungelelaniso aluphumelelanga ukufikelela ukubaluleka kwamanani emva kokulungiswa kweziphumo zovavanyo oluninzi. Akukho lunxulumano lunjalo lufunyenweyo kwigyrus yangaphambili ephezulu, i-orbitofrontal gyrus, i-gyrus rectus, i-parietal gyrus ephezulu, okanye i-gyrus yexesha eliphezulu. Idatha yomeleza ingcamango yokuba i-striatum kunye ne-anterior cingulate gyrus zibandakanyeka kulawulo lwemo. I-Dopamine-D2 i-receptors inokwenza indima ephambili kule ndawo.
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