IZIMVO: I-Testosterone efakwe kwisekethe yomvuzo inomvuzo ngeendlela ezifana neziyobisi ezikhobokisayo- oko kukuthi i-testosterone yenza ukuba kukhethwe indawo enemeko.
imvelaphi
ISebe leengqondo, iYunivesithi yaseNew Orleans, eLouisiana 70148, e-USA.
Abstract
Ubungqina obudlulileyo bubonisa ukuba kwipheripheral kunye ne-intranucleus accumbens inaliti of testosterone zibeneziphumo ezinomvuzo kwiimpuku ezingamadoda njengoko kulinganisiwe ku- imeko indawo ukhetho (CPP) iparadigm. Uphononongo lwangoku luphande iziseko ze-neurochemical zeempawu ezinomvuzo ze testosterone ngokuphonononga isiphumo se kwipheripheral kunye ne-intranucleus accumbens injection ye-dopamine receptor antagonist alpha-flupenthixol on nkulumo of testosterone-CPP eyenziwe. Ngeentsuku ezitshintshisanayo, iimpuku eziyindoda endala e-Long-Evans zafunyanwa kwipheripheral inaliti of testosterone kwi-hydroxypropyl-beta-cyclodextrin (HBC) e-soluble yamanzi (0.8 mg / kg) okanye i-saline-HBC ngokukhawuleza ngaphambi kokuvalelwa i-30 min ukuya kwelinye lamacandelo amabini indawo ukhetho izixhobo. Zonke iigundane zifumene iintsuku ze-8 zokubhanqa (ii-hormone ezine zokudibanisa, ii-saline pairings ezine). Ngomhla we-9 iimpuku zanikwa iseshoni yovavanyo lwemizuzu engama-20 apho zazikwazi ukufikelela kuzo zonke iikhompothi zezixhobo. Akukho hormone ifakwe ngaphambi kweseshoni yokuvavanya; nangona kunjalo, iimpuku zifumene a kwipheripheral (imizuzu engama-20 ngaphambili; 0.2, 0.3 mg / kg) okanye i-intra-accumbens (imizuzu emi-2 ngaphambili, iimicrogram eziyi-5.0) injection of alpha-flupenthixol okanye saline. Ngomhla wovavanyo, iimpuku zifumana ityuwa inaliti ixesha elichithwe kakhulu kwigumbi elidityaniswe nalo ngaphambili inaliti of testosterone kunakwikhompatimenti ebidityaniswe nesithuthi ngaphambili inaliti. Ngokuchaseneyo, iimpuku ezifumanayo kwipheripheral or i-intra-accumbens alpha-flupenthixol inaliti khange achithe ixesha elininzi kwikhompatimenti ebidityaniswe nayo ngaphambili testosterone. Ukuvalwa kwe testosterone I-CPP ayizange ibe ngenxa yesiphumo alpha-flupenthixol kwindlela yokuziphatha kwemoto. Iziphumo zibonelela ngobungqina obongezelelweyo beempawu ezichaphazelayo ezivuzayo ze testosterone kwaye ubonise ukuba kwipheripheral ulawulo kunye i-intra-accumbens ulawulo lwe alpha-flupenthixol ibhloko nkulumo of testosterone CPP. Iimpawu ezinomvuzo ezichaphazelekayo ze testosterone zidityanisiwe, ubuncinci ngokuyinxenye, ngokusebenzisana nenkqubo ye-mesolimbic dopamine.
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