ISIFUNDO ESIFUNDILEYO PDF
Abstract
Umsebenzi weDopamine (DA) kwindawo ye-medial preoptic (MPOA) inegalelo kulawulo lokuziphatha ngokwesondo kwamadoda. Siye savavanya (1) ukuba i-DA ye-extracellular iyanda ngexesha lokuvezwa kwangaphambili kwi-estrous female kunye nangexesha lokudityaniswa, (2) ukuba ukuvezwa kwenye indoda kwandisa i-DA ye-extracellular, (3) ingaba umsebenzi wemoto ngexesha lokudityaniswa kwee-akhawunti zokunyusa amanqanaba e-DA, kunye (4) nokuba i-testosterone yangoku okanye yamva nje ichaphazela amanqanaba e-DA okanye ukudibanisa kwi-castrates. I-DA ye-Extracellular kunye ne-metabolites yayo kwiigundane ze-MPOA zamadoda zilinganiswe ngokusebenzisa i-microdialysis. Inqanaba le-DA lenyuka ngexesha lokuvezwa kwangaphambili kwimazi kuzo zonke izilwanyana eziye zaphinda zadityaniswa; oku kuquke zonke izilwanyana ezingaguqukiyo, zonke i-testosterone-treated castrates, kunye ne-9 ye-14 i-1-iveki yokuthenwa kwe-oyile ephathwa ngesithuthi se-oyile. Amanqanaba e-DA awazange anyuke nakwesiphi na isilwanyana esathi emva koko asiphumelelanga ukulinganisa, kubandakanywa ne-1-iveki eseleyo, kunye nayo yonke i-2-iveki, i-castrates ephathwa ngemoto. Xa umqobo ususiwe kwaye izilwanyana zivunyelwe ukuba zihlangane, amanqanaba e-DA kunye ne-metabolites yayo aqhubeka enyuka kwindoda ephilileyo kunye nama-castrates adibeneyo. Impendulo ye-DA kowasetyhini e-estrous ayinakubalelwa kwi-nonsexual social stimuls, kuba ukutyhileka kwenye indoda kwakungaphumeleli. Impendulo ye-DA ekudityanisweni kwayo ayinakubalelwa ikakhulu kwintshukumo yemoto, kuba izilwanyana zibaleka ngokuzithandela kwivili lokubaleka azizange zibonise ukwanda kakhulu kweDA. Ezi kunye nedatha yangaphambili zibonisa ukuba i-DA ekhutshwe kwi-MPOA ekuphenduleni ibhinqa eli-estrous linokuba negalelo kwimpembelelo yezesondo kunye nobuchule bokukopa. I-Testosterone inokukhuthaza ukudibanisa ngokuyinxenye ngezenzo zokuvumela ukukhutshwa kwe-dopamine.
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