Iyafumaneka kwi-intanethi 28 ngo-Novemba 2016
Iimbalasane
•GABAA ii-receptors ngokwahlukileyo zilawula ukuhlangana ngokuxhomekeke kwimeko yesondo.
•I-Systemic bicuculline ibuyisela umva ukuhlutha ngokwesondo, kodwa ayinasiphumo kwiimpuku zamadoda ezisabela ngesondo.
•I-Intra-VTA bicuculline yenza ukuba kuhlangane iimpuku zamadoda ahluthi ngokwesondo.
•I-GABA ilawula ukuziphatha kweempuku zamadoda ekuphenduleni kwi-VTA
Abstract
Usasazo lwe-GABAergic kwindawo ye-ventral tegmental (VTA) inempembelelo ye-tonic inhibitory kumsebenzi we-mesolimbic dopaminergic neurons. Ukuvalwa kweVTA GABAA ii-receptors zonyusa ukukhutshwa kwe-dopamine kwi-nucleus accumbens (NAcc). Ukonyuka kwamanqanaba e-NAcc dopamine ngokuqhelekileyo ahamba nomboniso wokuziphatha ngokwesondo. Ukudibanisa kwi-satiety kubonakaliswe ngengxelo yexesha elide (72 h) inhibition yokuziphatha ngokwesondo kunye nenkqubo ye-mesolimbic ibonakala ibandakanyeka kule nto. Usulelo lwe-GABAergic kwi-VTA lunokudlala indima ekugcinweni kwesi sithintelo sesondo sihlala ixesha elide. Ukuvavanya le ngcamango, kulo msebenzi wangoku siphande umphumo we-GABAA i-receptor blockade kumadoda aphelelwe yisikhathi ngokwesondo i-24 h emva kokubambisana kunye ne-satiety, xa imeko ye-sex inhibitory state isungulwe, kwaye ithelekisa kunye nefuthe layo kwiigundane ezinamava ngokwesondo. Iziphumo zibonise ukuba iidosi eziphantsi ze-bicuculline ezilawulwa ngokusemthethweni zikhuthaza ukuziphatha ngokwesondo kwiigundane ezidiniweyo ngokwesondo, kodwa zingenaso isiphumo sokudityaniswa kwezilwanyana ezinamava ngokwesondo. I-Intra-VTA ye-bilateral infusion ye-bicuculline ayizange iguqule indlela yokuziphatha ngokwesondo yamagundane anamava ngokwesondo, kodwa yenza ukuba ukuziphatha ngokwesondo kubonakaliswe kuwo onke amadoda aphelelwe ngamandla ngokwesondo. Ke, i-GABA idlala indima kulawulo lwendlela yokuziphatha ngokwesondo kwi-VTA. Indima edlalwe lusasazo lwe-GABAergic ekubonakalisweni kokuziphatha ngokwesondo kwezilwanyana ezineemeko ezahlukeneyo zokuziphatha ngokwesondo iyaxoxwa.
Internet
- GABAA abamkeli;
- i-bicuculline;
- I-VTA;
- ukuthintela ngokwesondo;
- ukuhlutha ngokwesondo;
- ukuziphatha ngokwesondo kwamadoda;
- inkqubo ye-mesolimbic;
- ukuphendula ngokwesondo
;