Pharmacol Biochem Behav. 2013 Oct 12. pii: S0091-3057 (13) 00238-4. doi: 10.1016/j.pbb.2013.10.004.
Bijlsma EY, Chan JS, UOlivier B, Ukubona JG, Millan MJ, Waldinger MD, Oosting RS.
imvelaphi
Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Sorbonnelaan 16, 3584CA Utrecht, The Netherlands.
Abstract
I-Antidepressant-induced dysfunction yesondo ichaphazela kakubi umgangatho wobomi babasebenzisi be-antidepressant kwaye inciphisa ukuthotyelwa kwonyango. Iimodeli zezilwanyana zibonelela ngendlela efundisayo yokuvavanya iziphumo ebezingalindelekanga zesondo zamachiza anoveli. Olu phononongo luxoxa ngokuzinza kunye nokuphindaphinda kwenkqubo yethu yovavanyo olusemgangathweni oluvavanya iziphumo ezibukhali, ezingaphantsi kunye nezingapheliyo ze-psychoactive compounds kuvavanyo lwe-30minute mating. Ukongeza, sibonisa ujongo lweziphumo zeentlobo ezininzi ezahlukeneyo zoxinzelelo (i-putative) ekuziphatheni ngokwesondo kweempuku zamadoda, njengoko kuvavanywa kwinkqubo yethu yovavanyo olusemgangathweni. Ngokuthelekisa iziphumo zezi antidepressants zahlukileyo ngoomatshini (i-paroxetine, i-venlafaxine, i-bupropion, i-buspirone, i-DOV 216,303 kunye ne-S32006), olu phononongo luxoxa ngendlela yokubeka ephantsi kweziphumo ebezingalindelekanga zesondo ze-antidepressants kunye nokuqhelaniswa kwazo.
Olu phononongo lubonisa ukuba ukuziphatha ngokwesondo kuthintelwa ikakhulu zii-antidepressants ezonyusa i-serotonin neurotransmission nge-blockade yabathuthi be-serotonin, ngelixa ezo zonyusa kakhulu amanqanaba e-dopamine kunye ne-noradrenaline azinaziphumo ebezingalindelekanga zesondo. Ezo ziphazamiso ngokwesondo azinakwenziwa ziqheleke ngokunyusa kwangaxeshanye i-noradrenaline neurotransmission, kodwa iqhelekile ngokunyusa zombini i-noradrenaline kunye ne-dopamine neurotransmission. Ke ngoko, kucingelwa ukuba iziphumo ebezingalindelekanga zezesondo ze-serotonin reuptake inhibitors ezikhethiweyo zinokulamlwa ziziphumo zabo zokuthintela ekubonakalisweni kwe-dopamine kwiisekethe zobuchopho zesini. Uphuhliso lwezonyango lwenoveli yokudakumba kufuneka ke ngoko lugxininise kwiikhompawundi ezithi ngaxeshanye zonyuse zombini i-serotonin kunye nomqondiso we-dopamine.
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