I-Nutr Neurosci. 2017 Epreli 11:1-9. doi: 10.1080/1028415X.2017.1313583.
UKim JY1, UKim D1,2, Ipaki K3, Lee JH1, Jahng JW1.
Abstract
IINJONGO:
Olu phononongo lwenziwa ukuvavanya iimpembelelo ze-dimorphic zesondo zokutya okufumaneka lula (HPF) ngexesha lokufikisa kwi-neurochemistry kunye noxinzelelo- / isimilo-njengehambo yokuziphatha kweempuku.
IINDLELA:
Amaduna abesilisa nabasetyhini iSprague-Dawley yayinokufikelela simahla kwicookie enesitofu (HPF) ukusukela ngosuku lwasemva kokubeleka kwi-28 ukongeza kwi-ad libitum chow, kunye namaqela olawulo afumene i-chow kuphela. Iimeko zokutya zaqhubeka kulo lonke ixesha lokuvavanywa, kwaye imilinganiselo yokuma kunye neendlela zokuziphatha zenziwa ngexesha lokukhula komncinci. Iigundana zenziwa phantsi kwee-ambulatory function, zaphakanyiswa kunye maze, kwaye iimvavanyo zokuqubha zanyanzelwa. Amanqanaba e-Corticosterone ngexesha le-2 h yoxinzelelo yoxinzelelo ahlaziywa nge-radioimmunoassay, kunye ne-ΔFosB kunye nengcaciso evela kwi-neurotrophic factor (BDNF) kwi-nucleus accumbens (NAc) ngohlalutyo lweNtshona.
IINKCUKACHA:
Ukufikelela kukhukhi akuzange kuchaphazele ukuzuza komzimba kunye nokufumana i-caloric iyonke kwisini; nangona kunjalo, yonyusa i-depoperitoneal fat depot kuphela emadodeni. Ixesha elichithwe ezingalweni ezivulekileyo ngexesha lovavanyo oluphakanyisiweyo kunye ne-maze lwaluncitshisiwe kwaye ukungasebenzi ngexesha lokunyanzelwa kovavanyo lokubhukuda kwandisiwe kumadoda atya ukutya okwenziwa yi-cookie, kodwa hayi kubasetyhini abondliwe kukhukhi. Iziphumo eziphambili zokutya kwimeko yokunyuswa koxinzelelo lwe-corticosterone yabonwa emadodeni, kodwa hayi kwabasetyhini, kunye nokufikelela kukhukyo kukonyusa ukubonakaliswa kweBDNF kwi-NAc kuphela emadodeni.
IMISEBENZI:
Ukunyusa ukubonakaliswa kwe-BDNF kwi-NAc kunye ne-depot ye-fat, ukongeza kwi-axis dysfunction, kungadlala iindima kwi-pathophysiology yoxinzelelo- kunye / okanye indlela yokuziphatha enomdla yokufumana ikuki.
IINKCUKACHA: iCorticosterone; Ukutya kokutya; I-Nucleus accumbens; Uxinzelelo
PMID: 28399791
DOI: I-10.1080 / 1028415X.2017.1313583