I-Psychopharmacology (Berl). 2018 Jan; 235 (1): 23-35. doi: 10.1007/s00213-017-4744-0. Epub 2017 Okt 30.
UDi Ciano P1, Manvich DF2, Pushparaj A1, Gappasov A1, Hayi EJ3, Weinshenker D2, I-Foll B4,5,6,7,8,9,10.
Abstract
INDLELA YOKUZIPHATHA:
Ingxaki yokungcakaza yinkxalabo ekhulayo yoluntu, njengoko ibonwa luhlelo lwayo lwamva nje njengokuphazamiseka kokulutha kwi-DSM-5. Iingxelo zetyala zibonise ukuba i-disulfiram inciphisa ukuziphatha okunxulumene nokungcakaza ebantwini.
IINJONGO:
Injongo yolu phononongo yangoku yayikukufumanisa ukuba i-disulfiram ichaphazela ukusebenza komsebenzi wongcakazo wempuku, inguqulelo yempuku yomsebenzi we-Iowa wokungcakaza ebantwini, nokuba kukho naziphi na iinguqu ezayanyaniswa notshintsho kumanqanaba e-dopamine kunye/okanye norepinephrine.
IINDLELA:
Iimpuku zazilawulwa nge-disulfiram ngaphambi kokuvavanywa kumsebenzi wokungcakaza iimpuku okanye ngaphambi kohlalutyo lwe-dopamine okanye amanqanaba e-norepinephrine kwi-homogenates yobuchopho. Iimpuku kumsebenzi wokuziphatha zahlulwe zaba ngamacandelwana amabini (efanelekileyo vs eyongezelelekileyo) ngokusekwe kumanqanaba azo asisiseko okusebenza kumsebenzi wokungcakaza iimpuku. Iimpuku kwiqela elilelona liphezulu likhethe isicwangciso esinenzuzo ngakumbi, kunye neempuku kwiqela le-suboptimal (i-parallel kwingxaki yokungcakaza) yakhetha iqhinga elibi ngakumbi. Iigundane azizange zohlulwe zibe ngamaqela afanelekileyo okanye angaphantsi ngaphambi kohlalutyo lwe-neurochemical.
IINKCUKACHA:
I-Disulfiram ilawulwa i-2 h, kodwa ingabi yi-30 min, phambi kokuba idosi yomsebenzi-ixhomekeke ekuphuculeni ukuziphatha okukhethiweyo kwiigundane kunye neqhinga lokuqala elibi "lokungcakaza-njengokungcakaza", ngelixa lingenalo ifuthe kwiigundane ezisebenzisa isicwangciso esiluncedo. Iziphumo zokuziphatha ze-disulfiram zayanyaniswa nokunyuka kwe-striatal dopamine kunye nokuncipha kwe-norepinephrine ye-striatal.
IMISEBENZI:
Ezi ziphumo zibonisa ukuba izenzo ezidityanisiweyo kwi-dopamine kunye ne-norepinephrine inokuba lunyango oluluncedo lokuphazamiseka kokungcakaza.
IINKCUKACHA: I-Antabuse iDopamine; Ukungcakaza; Norepinephrine
PMID: 29085979
PMCID: PMC5750121
DOI: 10.1007/s00213-017-4744-0
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