Mol Psychiatry. 2014 Dec; 19 (12): 1305-13. doi: 10.1038/mp.2013.163. Epub 2013 Dec 10.
Boileau mna1, Umrholisi D2, UChugani B3, Lobo DS4, Houle S5, Wilson AA5, U-Warsh J6, Kish SJ7, UZack M8.
Abstract
Ukukhotyokiswa ziziyobisi kuye kwanxulunyaniswa nokusilela kumsebenzi we-mesostriatal dopamine (DA), kodwa ukuba eli lizwe liyanwenwela na kwindlela yokuziphatha efana nokungcakaza nge-pathological (PG) akucaci. Apha sisebenzise i-positron emission tomography kunye ne-D3 receptor-preferring radioligand [(11)C] -(+)-PHNO ngexesha leprotocol ye-double-scan ukuphanda ukukhululwa kwe-DA ekuphenduleni i-amphetamine yomlomo kwi-pathological gamblers (n = 12) kunye nempilo. ulawulo (n=11). Ngokuchaseneyo neziphumo ze-neuroimaging zomntu kumlutha weziyobisi, sixela ubungqina bokuqala bokuba i-PG inxulunyaniswa nokukhutshwa okukhulu kwe-DA kwi-dorsal striatum (54-63% enkulu [(11)C] -(+) -PHNO yokufuduka) kunolawulo. Okubalulekileyo, impendulo ye-dopaminergic kwi-amphetamine kubangcakazi yaxelwa kwangaphambili ngamanqanaba e-D3 receptor (elinganiswe kwi-substantia nigra), kwaye enxulumene nobungqongqo bokungcakaza, ukuvumela ukwakhiwa kwemodeli yobuchwephesha enokunceda ukuchaza igalelo le-DA kwiPG. OIziphumo ze-ur ziyahambelana nemeko ye-hyperdopaminergic kwi-PG, kwaye ixhasa i-hypothesis yokuba i-dopaminergic sensitization ebandakanya iindlela ezinxulumene ne-D3 inokuba negalelo kwi-pathophysiology yokulutha kokuziphatha.
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