Scand J Psychol. 2011 Feb;52(1):28-34. doi: 10.1111/j.1467-9450.2010.00837.x.
I-Linnet J, Møller A, UPeterson E, Gjedde A, Doudet D.
Iziko le-Functional Integrative Neuroscience, iYunivesithi yaseAarhus, iSibhedlele seYunivesithi yaseArhus, eArhus C, eDenmark. [imeyile ikhuselwe]
Abstract
Inkqubo ye-dopamine kukholelwa ukuba iyayichaphazela indlela yokuziphatha yongcakazo kungcakazo ye-pathological. Ngokukodwa, ukukhutshwa kwe-dopamine kwi-ventral striatum kubonakala kuchaphazela ukwenza izigqibo kukuphazamiseka. Olu phononongo luphande ukukhutshwa kwe-dopamine kwi-ventral striatum ngokunxulumene nokusebenza kongcakazo kwi-Iowa Gambling Task (IGT) kwi-16 Pathological Gamblers (PG) kunye ne-14 yoLawulo lweMpilo (HC). Sisebenzise i-Positron Emission Tomography (PET) ukulinganisa amandla okubopha i- [(11)C] i-raclopride kwi-dopamine D2/3 receptors ngexesha lesiseko kunye nemeko yokungcakaza. Siye saqikelela ukuba yehla amandla okubopha i-raclopride kwi-ventral striatum ngexesha lokungcakaza (ebonisa ukukhutshwa kwe-dopamine) kuya kunxulunyaniswa nokusebenza okuphezulu kwe-IGT kuLawulo oluphilileyo, kodwa ukusebenza okuphantsi kwe-IGT kuBangcakazo bePathological. Iziphumo zabonisa ukuba i-Pathological Gamblers ngokukhutshwa kwe-dopamine kwi-ventral striatum yayinentsebenzo ephantsi kakhulu ye-IGT kunoLawulo lweMpilo. Ngaphaya koko, ukukhutshwa kwe-dopamine kwanxulunyaniswa nokusebenza okuphezulu kakhulu kwe-IGT kuLawulo lweMpilo kunye nokusebenza okuphantsi kwe-IGT kwi-Pathological Gamblers. Iziphumo zibonisa ukuba ukukhutshwa kwe-dopamine kubandakanyeka kokubini kwi-adaptive kunye ne-maladaptive yokwenza izigqibo. Ezi ziphumo zinokuba negalelo ekuqondeni ngcono ukungasebenzi kakuhle kwe-dopaminergic kungcakazo lwe-pathological kunye neziyobisi ezinxulumene neziyobisi.
© 2010 Ababhali. Ijenali yaseScandinavia yePsychology © 2010 iScandinavian Psychological Associations.
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