Br J Psychiatry. 2015 Jun 4. pii: bjp.bp.114.152223.
I-Verdejo-Garcia A1, Clark L1, Verdejo-Roman J1, UAlbein-Urios N1, UMartinez-Gonzalez JM1, Gutierrez B1, ISoriano-Mas C1.
Abstract
imvelaphi
Abantu abane-cocaine kunye neziyobisi zokungcakaza babonisa ukusilela kwengqondo okunokuthi kube phantsi kokuzingisa kokuziphatha okuyingozi.
Iinjongo
Siphande i-neural substrates yokungaguquguquki kwengqondo kubasebenzisi be-cocaine v. abangcakazayo be-pathological, sijonge ukuphazamisa iindlela eziqhelekileyo ze-cocaine iziphumo.Indlela elishumi elinesibhozo abasebenzisi be-cocaine, i-18 yokungcakaza kwe-pathological kunye nolawulo lwe-18 benze umsebenzi wokufunda okubuyisela umva ngexesha lokucinga kwemagnethi esebenzayo, kwaye i-genotyped ye-DRD2/ANKK Taq1A polymorphism.
iziphumo
Abasebenzisi beCocaine kunye nabangcakazayo be-pathological babonise isibonakaliso esincitshisiweyo se-ventrolateral prefrontal cortex (PFC) ngexesha lokutshintsha umva. Abasebenzisi beCocaine baphinde babonise ukonyuka kwe-PFC (dmPFC) eyongeziweyo esebenzayo ngokunxulumene nabangcakazi be-pathological ngexesha lokuzingisa, kunye nokuncipha kokuvula i-dorsolateral PFC ngokunxulumene nabangcakazi be-pathological kunye nolawulo ngexesha lokutshintsha. Iziphumo zangaphambili zofuzo zibonise ukuba abasebenzisi be-cocaine abaphethe i-DRD2/ANKK Taq1A1+ genotype banokufumana iziphumo ezivuselelayo ezihambelana nokutshintsha kwe-ventrolateral PFC uphawu.
izigqibo
Ukwehliswa kokusebenza kwe-PFC ye-ventrolateral ngexesha lokutshintsha kunokwenza i-neural marker eqhelekileyo kulo lonke ungcakazo kunye neziyobisi ze-cocaine. Iziphumo ezongezelelekileyo ezinxulumene ne-cocaine zihambelana nepateni ebanzi ye-dysregulation enxulumene nomsebenzi, ebonakaliswa kuphawu olungaqhelekanga kwi-dorsolateral kunye ne-dmPFC.
;