I-Ar Ar Psychchiin Clin Neurosci. 2015 Mar 27.
Isibonelelo JE1, Odlaug BL, IChamberlain SR.
Abstract
Ingxaki yokungcakaza isandula ukwamkelwa njengeprototype 'isimilo sokuziphatha' ngenxa yokubandakanywa kudidi lwe-DSM-5 'lweZinto ezinxulumene neziyobisi kunye neNgxaki yokuLungisa.' Ngaphandle kwesimo sayo esandula ukufunyanwa kunye nenqanaba lokuxhaphaka kwe-1-3% kwihlabathi liphela, kuncinci okwaziwayo malunga ne-neurobiology yesi sifo. Iinjongo zolu phononongo yayikukuphonononga i-cortical morphometry kwisifo esingakhange sinyangwe sokungcakaza, okwesihlandlo sokuqala. Izifundo ezinengxaki yokungcakaza (N = 16) yasimahla kunyango lwangoku lwe-psychotropic okanye kwi-comorbidities yengqondo, kunye nolawulo olusempilweni (N = 17), bangeniswa kuphononongo kwaye benza imaging yamagnetic resonance (3T MRI). Ubungqingqwa beCortical babuchazwa kusetyenziswa ubuchwephesha besahlulo esizenzekelayo (iFreeSurfer), kwaye umahluko weqela wachongwa kusetyenziswa uhlalutyo lweqela elinemvume, ngokulungiswa okungqongqo kuthelekiso oluninzi. Ingxaki yokungcakaza inxulunyaniswa nokwehliswa okubonakalayo (umndilili we-15.8-19.9%) kubukhulu be-cortical, ngokuchaseneyo nolawulo, ubukhulu becala kwimimandla engaphambili yecortical. Ixelwe kwangaphambili ukungahambi kakuhle kwengqondo kwi-morphometric engalunganga kwenzeka ekungcakazeni ukungcakaza, ixhasa ukugcwala kwe-neurobiological kukuphazamiseka kweziyobisi kunye nokuhlelwa kwayo kutsha nje njengokuziphatha gwenxa. Umsebenzi wexesha elizayo kufuneka uphonononge umkhwa xa kuthelekiswa nobume bezinto ezifunyanisiweyo kunye nokuba ukufana okukhoyo na nezinye izinto ezingabekelwanga mva ngokuziphatha.
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