Sci Rep. 2017 Nov 24;7(1):16306. doi: 10.1038/s41598-017-16433-y.
Genauck A1,2, Umgangatho S3,4, Wüstenberg T3, UMörsen C.3, Heinz A3, I-Romanczuk-Seiferth N3.
Abstract
Iimpawu zokujonga intsholongwane yokungcakaza kunye nokuxhomekeka kotywala (AD) kubandakanya ukuzibandakanya okuphindaphindiweyo ngaphandle kokufumana iziphumo ezibi. Nangona kunjalo, umbono wento yokulahlekileyo (LA) njengenxalenye yokuthathwa kwezigqibo ngokusekwe kwixabiso awukasetyenziswa ukuthelekisa ngokuthe ngqo oku kuphazamiseka. Sinciphise i-LA ekunciphiseni ukugembula kwe-pathological (PG) kunye nezigulana ze-AD, ulungelelwaniso lwe-LA ngobunzima bokuphazamiseka, kunye nokuncitshiswa kokuchaphazela okunxulumene nokulahleka komsebenzi wobuchopho. Izifundo ze-19 PG, izigulana ze-15 AD kunye nolawulo olusempilweni lwe-17 (HC) zibandakanyeka kumsetyenzana we-LA kwisimo esisebenzayo semagneti eshukumisayo. Ukulinganisa ukuhlalutya kugxile ekuzuzeni kwe-neural kunye nokulahleka kwemvakalelo kwinethiwekhi-cortico-limbic network yengqondo. Zombini izifundo ze-PG kunye ne-AD zibonise ukunciphisa i-LA. Izifundo ze-AD zibonise ukuguqulwa kwemeko enxulumene nelahleko eguqukayo kwimimandla yangaphambili. Izifundo ze-PG zibonise isibonisi esiguquliweyo se-amygdala-pre-prealal functionxised. Nangona sabona kuncitshiswe i-LA kokubini kwisimo sokuziphatha kunye nengxaki enxulumene neziyobisi iziphumo zethu ze-neural zinokucela umngeni umbono wokuziphatha ngokupheleleyo kwe-neuro-yokuziphatha ukuchasana kokusebenzisa iziyobisi kunye nokuziphatha kakubi.
PMID: 29176580
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