Neuropsychopharmacology. 2015 Aug 20. doi: 10.1038 / npp.2015.253.
IKerstetter KA1, I-Wunsch AM1,2, Nakata KG1,2, Iirholithi E1, UNumauma JF2,3,4, UFerguson SM1,2,3.
Abstract
I-medial pre mapemaal cortex (mPFC) kunye ne-nucleus accumbens (NAc) zizinto zombini ezihlanganisiweyo ze-cortico-basal ganglia-thalamic circry ezilawula indlela yokuziphatha enxulumene nokuziphatha. Nangona kunjalo, indima yamagalelo afakiweyo ukusuka kwi-mPFC ukuya kwi-NAc kwezi ndlela zokuziphatha ayicacanga.
Ukuphelisa lento, sisebenzise indlela yokuxhomekeka kwentsholongwane ye-Cre-recombinase ukubonisa uGmna / oIi-DREADD -eziqulathiweyo (Abaqulunqi abaYamkeli ngokuSebenza ngokukhethekileyo ngabaSebenzisa iziyobisi) ngokukhetha ku I-neuron ye-mPFC esebenza kwi-NAc kwaye yajonga iziphumo zokufumana imisebenzi yezi neuron kwi-sensitization ye-amphetamine kunye nokuthatha iziyobisi kunye nokufuna iziyobisi ngexesha lokuzilawula kwe-cocaine.
Okothusayo, ukwehlisa umsebenzi we-mPFC wokudibana kwi-NAc kuphela okwethutyana kuncitshiswa kwemvakalelo yendawo kwaye akunampembelelo kukuthatha iziyobisi ngexesha lokuzilawula kwe-cocaine.
Nangona kunjalo, ukuthintela umsebenzi wobudlelwane be-corticostriatal ngexesha lokuvuselela uvakalelo oluphendulweyo kamva.
Ukongeza, oku kuxhaphaza ngexesha lokuzilawula kwamachiza kuye kwakhokelela ekucothisweni kwamanani anyanzeliswayo kwaye kwandiswa ukuphendula ngexesha lokubuyiselwa kweziyobisi- isiphumo esenziwa salungiswa ngokuthintela ezi zinto zidibeneyo zakwicorticostriatal kwangoko phambi kwentloko.
Ezi ziphumo zibonisa ukuba ukunciphisa ulawulo lwe-cortical kwi-NAc ngexesha lokuvezwa kweziyobisi kunokukhokelela kutshintsho lwexesha elide kubuchule bamachiza kunye nenkuthazo ehambelana nokuqhuba nokuziphatha.
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