IZIMVO: Ukuncipha kwe-cortex dopamine yangaphambili (eyenzeka kubukhoboka), kubangele impendulo enkulu kunye nenkulu ye-dopamine ekutyeni nakwisondo. Okunye okufunyaniswayo kukuba i-cortex dopamine yangaphambili iya kuthintela umsebenzi wesekethe yomvuzo.
J Neurosci. 1992 Sep;12(9):3609-18.
IMFUNDO EFILEYO PDF
UMitchell JB, uGratton A.
imvelaphi
Iziko loPhando lweSibhedlele saseDouglas, iSebe lezengqondo, iYunivesithi yaseMcGill, eMontreal, eQuebec, eCanada.
Abstract
I-chronoamperometry enesantya esiphezulu yayisetyenziselwa ukubeka esweni i-extracellular concentration ye-dopamine ngaphakathi kwe-nucleus accumbens, intsimi ye-terminal yenkqubo ye-mesolimbic dopamine, ekuziphatheni ngokukhululekileyo iigundane ezivezwa yonke imihla, ngeentsuku ze-6 ezilandelelanayo, ukuya kwesinye sezibini zokuqinisa ngokwemvelo; ukutya okunencasa kakhulu okanye iimpawu zokuvumba ezinxulumene nesondo.
Izilwanyana mhlawumbi bezigqibelele okanye bezikhe zafumana ii-microinjections ze-6-hydroxydopamine kwi-prefrontal cortex ukuya kwi-lesion dopamine terminals. Ukutya okuthenjiweyo kubangele ukonyuka kwamanqanaba e-dopamine ngaphakathi kwe-nucleus accumbens, kwaye ukuba i-prefrontal cortical dopamine ibicinyiwe, impendulo ekutyeni yonyuka ngovavanyo oluphindaphindiweyo. Izilwanyana ezivezwe kwi-olfactory ehambelana nesondo evuselelayo zibonise ngokuqhubekayo ukukhutshwa kwe-dopamine ngovavanyo oluphindaphindiweyo, kwaye olu phuculo lwalunokubakho ngenxa ye-prefrontal cortical dopamine depletion.
Ezi ziphumo zibonisa ukuba ukubonakaliswa okuphindaphindiweyo kwiziganeko zokuqinisa ngokwemvelo kunokukhokelela ekuphenduleni kwe-mesolimbic dopamine inkqubo ekusebenzeni kwexesha elizayo, kwaye iphakamisa ukuba i-dopamine projection kwi-prefrontal cortex inefuthe elingathanga ngqo, elithintelayo kwi-mesolimbic dopamine neurotransmission.
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