Utywala lweeNkcazo zoTywala. 2004 Dec;28(12):1829-38.
Abstract
UMGQUBO:
Ukuphuhliswa kokuxhomekeka kunokuba nemiphumo ebalulekileyo malunga nokuqhubeka nokusetyenziswa kunye nokuxhatshazwa kwe-ethanol. Siye saqulunqa imodeli yeempuku yokuxhomekeka kwe-ethanol kunye nokurhoxiswa okuphindaphindiweyo okubonisa ukuziva kokubanjwa kunye nezinye iimpawu zokurhoxa. Akukaziwa ukuba amava anjalo anefuthe lokuziphatha okusela kwe-ethanol. Olu ngcelele lwangoku lweemvavanyo zenzelwa ukujonga ukuba ngaba imijikelezo ephindaphindiweyo yokuchana okungapheliyo kwe-ethanol kunye nokurhoxa kunefuthe kwizizathu ezilandelayo zokuzimela ngokuzimela ekuzinziseni i-ethanol.
IINDLELA:
Ngokusetyenziswa kwenkqubo eguqulweyo yokuphela kwe-sucrose-fading, i-C57BL / 6J yeempuku zabantu abadala zaqeqeshwa ukusela i-15% (v / v) ethanol kwinkqubo yokufikelela encinci (i-2 hr / imini). Izilwanyana zazingekokutya okanye manzi ancitshisiweyo nangaliphi na ixesha ngexesha lovavanyo. Nje ukuba kusekwe ukuzinzisa kwesiseko esizinzileyo, iimpuku ziye zavezwa kwimijikelezo emine ye-16 hr ye-ethanol vapor (okanye umoya) kumagumbi okuphefumla ahlukaniswe ne8-hr amaxesha okurhoxa. Kwi-32 hr emva komjikelo wokugqibela wokuvezwa kwe-ethanol, zonke iigundane zavavanywa ukuba zithathwe kwi-ethanol phantsi kweemeko zokufikelela ezinqamlekileyo kwiintsuku ze-5 zilandelelana. Izilwanyana ke ziye zafumana uthotho lwesibini lokuvezwa kwe-ethanol engapheliyo kunye nokurhoxiswa kulandelwa lelinye ixesha leentsuku ze-5 zovavanyo lokusela i-ethanol.
IINKCUKACHA:
Ukutya okuzinzileyo okusisiseko kwemihla ngemihla kwasungulwa kwiimpuku ezisele i-15% ethanol zidityaniswe ne-5% sucrose (ilinge 1), 15% ethanol yodwa (ukuzama i-2), 5% sucrose yodwa (ukuzama i-3), okanye i-15% ethanol xa ibonakaliswa ngamanzi (ulingelo lwe-4). Emva kwemijikelezo ephindaphindiweyo yokubonakaliswa kwe-ethanol engapheliyo kunye namava okurhoxisa, ukusetyenziswa kwezisombululo ze-ethanol kunyuke ngaphezulu kwamanqanaba osiseko kunye nokuthelekiswa kwamaqela olawulo (abonakaliswe ngumoya). Nangona kunjalo, ukusetyenziswa kwe-sucrose akutshintshanga kwiimpuku eziqeqeshelwe ukusela i-5% sucrose. Ukonyuka kokusetyenziswa kwe-ethanol emva kokuvezwa kwe-ethanol engapheliyo kunye namava okurhoxisa kubangele ukwanda okukhulu kumanqanaba e-ethanol egazi.
IMISEBENZI:
Nje ukuba kusekwe iipropathi zokuqinisa i-ethanol, ukuvezwa okungapheliyo kwe-ethanol kunye namava okurhoxa kukhokelele kukonyuka okuphawulekayo kukusela kwe-ethanol ngokuzithandela okwavelise ukonyuka okuphindwe kabini kwinqanaba leethanol yegazi. Oku kunyuka kokutya kwe-ethanol kwenzeka nokuba i-ethanol yaziswa ngokudibanisa ne-sucrose, iyodwa (engangxengwanga), okanye njengokukhetha ngamanzi etephu. Ngaphaya koko, esi siphumo sibonakala ngathi sikhetha i-ethanol kwizilwanyana eziqeqeshelwe ukusela isisombululo se-sucrose azibonisanga lutshintsho ekutyeni kwabo emva kokuvezwa okufanayo kwe-ethanol engapheliyo. Kananjalo, le modeli inokuba luncedo ekufundeni iindlela kunye neemeko apho unyango lwe-ethanol engapheliyo luchaphazela inkuthazo yokuqhubeka nokusela emva kwexesha lokuyeka (ukubuyela umva).
PMID: 15608599
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