Prog Neuropsychopharmacol Biol Psychiatry. 2020 Epreli 20;99:109864. doi: 10.1016/j.pnpbp.2020.109864. Epub 2020 Jan 15.
UMascia P1, Wang Q1, UBrown J1, Nesbitt KM2, Kennedy RT3, UVezina P4.
Abstract
Kutshanje siye saxela ukuba i-nucleus accumbens (NAcc) dopamine (DA) ilandelela ukungaqiniseki ngexesha lokuphendula kwi-saccharin engeyo-caloric. Siphinde sabonisa ukuba ukubonakaliswa okuphindaphindiweyo koku kungaqiniseki, njengokuvezwa kweziyobisi zokusetyenziswa kakubi, kukhokelela ekuvakalisweni kwe-locomotor kunye ne-NAcc DA iziphumo ze-amphetamine kwaye ikhuthaza ukuzilawula kwechiza okulandelayo. Apha siphonononga ezi ziphumo kunye nezinye ezibonisa ukuba i-NAcc glutamate signing ichatshazelwa ngokufanayo kukungaqiniseki. Amanqanaba e-Extracellular e-glutamate kule ndawo aphinda alandele ukungaqiniseki kumsebenzi apho impumlo iphokoza i-saccharin kwishedyuli ekhulayo yomlinganiselo wokuqiniswa inxulunyaniswa nokwahluka okukhula okuqhubekayo phakathi kokusebenza komsebenzi kunye nentlawulo. Ngaphaya koko, indlela yokuziphatha eyandisiweyo yokuphendula kunye ne-amphetamine emva kokuvezwa kokungaqiniseki kukhatshwa ngamanqanaba okwanda kweCa.2+/ iprotein kinase II exhomekeke kwi-calmodulin (CaMKII) kunye neprotein kinase C (PKC) phosphorylation kunye namanqanaba eprotheyini atshintshiweyo ye-transcription factor ∆FosB (yandisiwe) kunye ne-glutamate transporter 1 (GLT1; iyancipha) kwii-NAcc tissues. Ngokucacileyo, i-phosphorylation yi-CaMKII kunye ne-PKC ilawula ukuthengiswa kwe-receptor ye-AMPA kunye nokusebenza kule ndawo, iphakanyisiwe emva kokuvezwa kwengqondo, kwaye iyimfuneko ekubonakalisweni kokusetyenziswa kweziyobisi okongeziweyo. Ukunyuka kwe-∆FosB kunye nokuncipha kwamanqanaba e-GLT1 kujongwa emva kokuba sesichengeni se-psychostimulant, anxulunyaniswa nokwanda kokuthatha ichiza kunye nokufuna, kwaye aziwa ngokumodareyitha ii-AMPA receptors kunye namanqanaba e-extracellular glutamate ngokulandelelanayo. Olu hlengahlengiso kwi-glutamate transmission kunye nezo zijongwe nge-DA emva kokuvezwa okuphindaphindiweyo kokungaqiniseki ziyafana nezo ziveliswa kukuvezwa kweziyobisi ezixhatshaziweyo. Ngokudibeneyo, bakhomba ekuqeshweni kwe-DA kunye neendlela zokubonisa i-glutamate kwi-NAcc kuzo zombini iziyobisi kunye nokuziphatha. Njengoko ukungaqiniseki kusembindini wemidlalo yamathuba, ezi zinto zifunyanisiweyo zinokubaluleka okukodwa kwiziphazamiso zongcakazo ezaziwa ngokubonisa ukuhambelana nokusetyenziswa gwenxa kweziyobisi.
IINKCUKACHA: iAmphetamine; iDopamine; Ukungcakaza; I-Glutamate; Ukuqonda; Ukungaqiniseki
PMID: 31952958
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