Iipeptides. 2014 Jul; 57: 122-8. doi: 10.1016/j.peptides.2014.05.004.
UDonlin M1, Cavanaugh BL1, I-Spagnuolo OS1, Yan L1, Lonstein JS2.
Abstract
Abemi abaninzi beeseli ezenza i-neuropeptide orexin (OX) zikhona kwi-caudal hypothalamus yazo zonke iintlobo ezivavanyiweyo kwaye zibandakanyeka kwiinkqubo zomzimba kunye nokuziphatha kubandakanya ukuvuswa, uxinzelelo, ukuxhalaba kunye nokudakumba, ukuvelisa, kunye nokuziphatha okujoliswe kuko. Intetho ye-Hypothalamic OX yi-sexual dimorphic kumacala ahlukeneyo kwiimpuku zaselabhoratri (F>M) kunye neempuku (M>F), icebisa iindima ezahlukeneyo kwiphysiology yamadoda nabasetyhini kunye nokuziphatha okuxhomekeke kuhlobo oluthile. Apha sivavanye ukuba ngaba inani leeseli ze-hypothalamic immunoreactive ze-orexin A (OXA) ziyahluka phakathi kwe-prairie voles yamadoda nabasetyhini (Microtus ochrogaster), uhlobo oluhlala umntu omnye ekuhlaleni oludibanisa i-pairbond emva kokukhwelana nalapho zombini izini zikhathalele inzala, kwaye ukuba amava okuzala aphembelela. inani labo OXA-immunoreactive (OXA-ir) iiseli. Kwafunyaniswa ukuba inani elipheleleyo leeseli ze-OXA-ir alizange lihluke phakathi kwesini, kodwa amabhinqa aneeseli ezininzi ze-OXA-ir kunamadoda kumanqanaba angaphambili e-caudal hypothalamus, ngelixa amadoda aneeseli ezininzi ze-OXA-ir ngasemva. Abasetyhini abanamava ngokwesondo babingelela iintsuku ezili-12 emva kokuzalwa kwe-litter yabo yokuqala, okanye usuku olunye emva kokuzalwa kwe-litter yesibini, babeneeseli ezininzi ze-OXA-ir kumanqanaba angaphambili kodwa ingengawo amanqanaba angasemva kwe-caudal hypothalamus xa kuthelekiswa nabasetyhini abahlaliswe nomntakwabo ukuphepha kuthintela ukukhwelana kwabantwana bakowenu). I-prairie voles yamadoda ayizange ibonise umphumo wamava okuzala kodwa ibonise umphumo ongalindelekanga wokuhlala ixesha elide ngaphandle kokukhwelana. Umahluko ngokwesini ekusasazweni kweeseli ze-OXA-ir, kunye nenani labo elandisiweyo kumanqanaba angaphambili e-caudal hypothalamus ye-female prairie voles enamava okuzala, inokubonisa indlela ethe ngqo yesini ebandakanyekayo kwi-pairbonding, umzali, okanye ukuncancisa kolu didi.
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