ACS Chem Neurosci. I-2015 Jan 21; 6 (1): 138-46. I-Doi: 10.1021 / cn500246j. Epub 2014 Dec 11.
CD yeNkosana1, Rau AR, Yorgason JT, España RA.
Abstract
Ubungqina obongezelelekileyo bubonisa ukuba ii-hypocretins / orexins ziphembelela ukuqiniswa kwe-cocaine kunye nokusayina dopamine ngezenzo kwi-hypocretin receptor 1.
Ngokuthelekisa, ukubandakanyeka kwe-hypocretin receptor 2 kumvuzo kunye neenkqubo zokuqinisisa zifumene ingqalelo encinci. Ke, nangona kukho ubungqina bokuba i-hypocretin receptor 2 ilawula ukuthathwa kweziyobisi ezithile zokuxhatshazwa, okwangoku akucaci ukuba li-hypocretin receptor 2 ithatha inxaxheba njani kulawulo lokusayina dopamine okanye i-cocaine self-management, ngakumbi phantsi kweemeko eziphezulu zokuzama. Ukujongana noku, sivavanye iziphumo ze-hypocretin receptor 1, kunye / okanye i-hypocretin receptor 2 blockade on signopop ye-dopamine kunye nokuqiniswa kwe-cocaine. Sisebenzise kwi-vivo ngokukhawuleza i-scan cyclic voltammetry yokuvavanya iziphumo zabachasene ne-hypocretin kwi-dopamine signaling in the nucleus accumbens core kunye neshedyuli yomgaqo oqhubekayo wokuvavanya iziphumo zezi zinto zichasene nolawulo lwe-cocaine. Iziphumo zibonisa ukuba i-blockade ye-hypocretin receptor 1 okanye zombini i-hypocretin receptor 1 kunye ne-2 zinciphisa kakhulu iimpembelelo ze-cocaine kwisiginali ye-dopamine kunye nokunciphisa ukukhuthaza ukuthatha i-cocaine. Ngokwahlukileyo, i-blockade ye-hypocretin receptor 2 iyodwa ayinaziphumo zibalulekileyo kwi-dopamine signaling okanye kwi-self-management.
Ezi ziphumo zibonisa ukubandakanyeka ngokungafaniyo kwezi receptor zehypocretin receptor, kunye ne-hypocretin receptor 1 ebonakala ngathi ibandakanyeka ngaphezulu kwe-hypocretin receptor 2 kulawulo lokusayina dopamine kunye nolawulo lwe-cocaine. Xa kuthathelwa ingqalelo kuncwadi olukhoyo, ezi datha zixhasa i-hypothesis ethi i-hypocretins isebenze ifuthe lokuvumela ukwenziwa kwe-dopamine kunye nokuziphatha okukhuthazayo ngezenzo ezikhethiweyo kwi-hypocretin receptor 1.
;