I-Eur J Pharm Sci. 2014 Jun 16;57:2-10. doi: 10.1016/j.ejps.2014.01.008. Epub 2014 Jan 25.
Ikota D1, Smolders I2.
Abstract
I-hypothalamus yinkqubo edityanisiweyo yokubona amandla edibana nezakhiwo ezikhuthazayo eziphezulu zenkqubo ye-mesocorticolimbic dopamine (DA). Oku kudityaniswa kulawulwa ngokungqongqo ngamanani e-orexigenic hypothalamic neuropeptides, kubandakanywa ngakumbi i-ghrelin, i-orexins kunye ne-neuropeptide Y (NPY), eyenza ukuba le yokugqibela imodareyithe iziganeko ezibalulekileyo zendalo kunye neekhemikhali zokuqinisa. Kolu hlaziyo sijonge ukuhlalutya ulwazi lwangoku kwezi nkqubo zintathu ze-orexigenic neuropeptide ezibandakanyekayo kulawulo lwe-DAergic lokuziphatha kwengqondo. Siza kuqala sihlolisise intsebenziswano ekhoyo phakathi kwe-ghrelin, i-orexins kunye ne-NPY kwi-nuclei ye-hypothalamic. Siza kuchaza ngokulandelayo ukuba ezi neuropeptides zinokuchaphazela i-DAergic neurotransmission ngokulawula izinga lokudubula kwe-DA neurons kwindawo ye-ventral tegmental (VTA) okanye ngokusebenzisana kwangaphambili kwi-terminal ye-DAergic nerve. Okokugqibela, siya kugxininisa izifundo eziphambili ezichaza ukubandakanyeka kwe-ghrelin, i-orexins kunye ne-NPY ngokuvuza, ukomeleza kunye neempawu zenkuthazo zabaqinisi bendalo kunye neziyobisi zokuxhatshazwa. Ukunxibelelana kwe-hypothalamic ye-ghrelin, i-orexins kunye ne-NPY inokumela umbono omtsha ophambili kwiindlela ze-neuronal ezilawula i-phenomenology yokuziphatha yokulutha egcinwe yinkqubo ye-DA.
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