Neuroscience. 2012 Aug 30;218: 138-53. doi: 10.1016/j.neuroscience.2012.05.033. Epub 2012 Meyi 22.
Nocjar C1, UZhang J, Feng P, Panksepp J.
Abstract
I-Anhedonia luphawu olungundoqo loxinzelelo lwezonyango. Iineuropeptides ezimbini zobuchopho eziye zabandakanyeka kwi-anhedonia symptomology kwiimodeli zokudakumba kwangaphambili ziyi-dynorphin kunye ne-orexin; ezigxile ecaleni kwendlela yomvuzo we-hypothalamic dopamine. Ezi zichaphazela ukulawula i-neuropeptides zimodareyitha umsebenzi womnye nomnye, zibandakanya ukungasebenzi kakuhle phakathi kwazo kwi-anhedonia symptomology.
Kodwa nokuba iimpembelelo zabo ziguquliwe okanye azilingani ngaphakathi kwe-hypothalamus okanye inkqubo ye-dopamine kwiimodeli zokudakumba kwe-anhedonic preclinical ayikacaci.
Sasebenzisa i-radioimmunoassay ukumisela oku kwimodeli yokoyiswa kwentlalo yempuku yokudakumba; ngexesha apho ukungathandeki ngokwesondo kwe-anhedonic kubonakaliswe. Kwiisampulu zezicubu ze-medial prefrontal cortex (mPFC), indawo ye-ventral tegmental (VTA) kunye ne-nucleus accumbens, amanqanaba e-basal dynorphin ayefana nezilwanyana eziqhelekileyo. Kodwa i-orexin yancitshiswa kwi-VTA kunye ne-mPFC.
Kwakhona, i-dynorphin kunye ne-orexin zombini ziye zancipha kwi-hypothalamus ephawulekayo kuba phantse zonke iiseli ze-hypothalamic orexin zi-express dynorphin. Ezi ziphumo zibonisa ukuba umsebenzi we-orexin kunye ne-dynorphin unokungalingani phakathi kwe-hypothalamus kunye nemimandla yengqondo ye-mesocortical dopaminergic kuxinzelelo.
;