Behav Neurosci. 2013 Jun;127(3):458-64. doi: 10.1037/a0032332.
UGarduño-Gutiérrez R, Guadarrama-Bazante L, I-León-Olea M, URodríguez-Manzo G.
imvelaphi
Isebe leFarmacobiología, Cinvestav Sede Sur, Cinvestav Sede Sur, México City, México.
Abstract
Ukuphambuka komzimba kukhuthaza ukukhutshwa kwe-opioid opoid. Ukupheliswa kokukhathala kuvelisa iinguqu ezingapheliyo zokuziphatha nezomzimba, phakathi kwazo indlela yokuziphatha engapheliyo ngokwesondo kunye ne-hypersensitivity jikelele yeziyobisi zezona zibalulekileyo. Kungenxa yokuba ikopi ekukhuseleni ibandakanya ukuvela ngokulandelelana okuphindaphindiweyo, kulo msebenzi sigqithise ukuba ii-opioids ze-endo zemveli ezikhutshwe zi-ejukoations ezininzi ngexesha lokukhuphela inkqubo yokuphelisa amandla kuya kuguqula utshintsho olukhankanyiweyo ngokwesini oluchazwe ngasentla. Ukuvavanya le hypothesis, iigundane ezingamadoda ezabelana ngesondo zifakwe kwisifo se-opioid receptor antagonist naltrexone ngaphambi kokukhupha ukudinwa kwaye kwavavanywa indlela yokuziphatha ngokwesondo okanye i-hypersensitivity 24 h kamva. Le yokugqibela yavavanywa ngokubonakala komqondiso wokuma komzimba kwiflethi ye-serotonergic syndrome, ekuphenduleni idosi ye-5-hydroxytryptamine-1A (5-HT1A) i-receptor agonist 8-hydroxy-2-di-n-propylamino-tetralin ( I-8-OH-DPAT), iphantsi kunezo ziqhelekileyo zokuphembelela olu phawu. Isiphumo sokuhambisa i-naltrexone kwizilwanyana esele ziphelelwe ngamandla ngokwesondo (okt, i-24 h emva kwenkqubo yokuhluthwa ngokwesini) kuzo zombini iimpendulo zavavanywa.
Iziphumo zibonise ukuba i-opioids engapheliyo ilamla ukusekwa kunye nokugcinwa kwe-inhibition yokuziphatha ngokwesondo ixesha elide kodwa hayi i-hypersensitivity yeziyobisi. (ukuya ku-8-OH-DPAT) uphawu lweempuku zamadoda ezidinwe ngokwesondo. Kugqitywe ekubeni nangona zombini ezi ziganeko zibonakala zisisiphumo sokudityaniswa kwe-satiation kwaye zilandela ixesha elifanayo lokuchacha, ziya ziveliswa ngeendlela ezahlukeneyo.
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