Izimvo: TeAmanqanaba e-stosterone awazange ahluke ngokudibanisa enye okanye ngokudibanisa ukudinwa ngokwesondo. Ukukhupha ubudoda ukuya ekudinweni idibeneyo ukuhla kwingqondo ye-androgen receptors.
Fernandez-Guasti A, Swaab D, Rodriguez-UManzo G.
Psychoneuroendocrinology. 2003 May;28(4):501-12.
KwiSebe Pharmacobiology, CINVESTAV, Calz. de Los Tenorios I-235, iCor. I-Granjas Coapa, Mexico 14330 DF, Mexico. jfernand@imeyile.cinvestav.mx
KWI-ABSTRACT
Ukuziphatha kwamadoda ngokwesondo kulawulwa ngu limbic iindawo ezifana ne-medial i-preoptic i-nucleus (MPN), i-nucleus yebhedi ye-stria itheminali (BST), i-nucleus uqokelela (nAcc) kwaye i i-ventromedial i-hypothalamic i-nucleus (VMN). IiNeurons kwezi ndawo zobuchopho zizityebi kwi-ANDROGEN RECEPTORS (AR) kwaye ubonise i-FOS-ukungasebenzi kakuhle ekuphenduleni ukukhwelana. Kwiintlobo ezininzi ze-sexual satiation, imeko yokuthintela ukuziphatha ngokwesondo, ifunyenwe emva kokuphuma amaninzi.. Iindlela ezisisiseko sokwaneliseka ngokwesondo azaziwa ubukhulu becala. Kolu phononongo sibonisa ukuba umsebenzi wesondo unciphisa i-androgen receptor ukungasebenzi kakuhle (I-ANDROGEN RECEPTORS –ir) kwezinye iindawo zobuchopho ezinxulumene nolawulo lokuziphatha ngokwesondo kwamadoda, kodwa hayi kwezinye. Ngaloo ndlela, enye i-ejaculation yanciphisa i-AR-ir kwiMPN kunye nAcc, kodwa hayi kwi-BST kunye ne-VMN. Ukudibanisa ukuya kwi-satiation, kwelinye icala, kuncitshiswe i-AR-ir kwiMPN, nAcc kunye ne-VMN, kwaye hayi kwi-BST. I-AR-ir ukunciphisa okubonwe kwi-MPN yeegundane ezihluthwe ngokwesondo kwakunzima xa kuthelekiswa nezilwanyana ezikhupha kanye.
Amanqanaba e-androgen e-serum awazange ahluke emva kokuphuma kwe-ejaculation okanye ukudibanisa ukudinwa. Ezi nkcukacha zityhila ukuba umsebenzi wesondo unciphisa i-ANDROGEN RECEPTORS kwiindawo ezithile zobuchopho kwaye iphakamisa ukuba kunokwenzeka ukuba ukunciphisa okunjalo kuphantsi kwesithintelo sesondo esibonakalisa ukuhlutha ngokwesondo.
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