Ukucatshulwa kwemilotiki kubonisa ukuba inyosi engapheliyo yokutshaya iyaphazamisa ubuchopho beengqondo
Juni 6th, 2011 kwi-Neuroscience
Ubungqina obucacileyo besiphumo esibi sokusetyenziswa kwentsangu okungapheliyo esityhilwe kwiNtlanganiso yoNyaka yama-58 yeSNM kunokukhokelela kunyango olunokubakho kunye nokunceda olunye uphando olubandakanyekayo kwii-cannabinoid receptors, inkqubo ye-neurotransuction yokufumana ingqwalaselo enkulu. Oososayensi basebenzise imaging yemolekyuli ukujonga ngamehlo utshintsho olwenzeka kwiinkuku ezinamandla zentsangu xa kuthelekiswa nabantu abangatshayiyo kwaye bafumanisa ukuba ukusetyenziswa gwenxa kwesiyobisi kukhokelele kwinani elinciphileyo le-CB1 receptors, ezingabandakanyekanga kulonwabo, ukuthanda ukutya kunye nokunyamezeleka kwentlungu yeminye imisebenzi yengqondo kunye nokuma komzimba.
UJussi Hirvonen, MD, PhD, umbhali ophambili wesifundo sentsebenziswano phakathi kweZiko leSizwe lezeMpilo yeNgqondo kunye neZiko leLizwe lokuSetyenziswa gwenxa kweziyobisi, eBethesda, Md. ukuqonda iindlela ze-neurobiological ezichaphazelekayo kwikhoboka leziyobisi. Ngalesi sifundo, sikwazile ukubonisa okokuqala ukuba abantu abahlukumeza i-cannabis banokungaqhelekanga kwe-cannabinoid receptors kwingqondo. Olu lwazi lunokungqina lubalulekile kuphuhliso lonyango lwenoveli lokuxhatshazwa kwe-cannabis. Ngapha koko, olu phando lubonisa ukuba ukwehla kwezamkeli kubantu abasebenzisa kakubi i-cannabis babuyela esiqhelweni xa beyeka ukutshaya ichiza. ”
Ngokutsho kweNational Institute of Drug Abuse, i-marijuana yile nombolo-enye yeziyobisi ezingekho mthethweni eMelika. Ikhemikhali yengqondo engqondweni, okanye i-cannabis, i-delta-9-tetrahydrocannabinol (THC), ebophelela kwiimvumi ezininzi ze-cannabinoid engqondweni nasemzimbeni wonke xa zitshiza okanye zitshiswa, zivelisa eziphezulu. Iimvumi ze-Cannabinoid ebuchosheni zichaphazela udidi lweengqondo nezenzo, kuquka ukuzonwabisa, ukuxininisa, ukujonga ixesha kunye nenkumbulo, ukuqonda kwengqondo, kunye nokulungelelaniswa kokuhamba. Kukho i-receptor ye-cannabinoid kuwo wonke umzimba ochaphazelekayo kwimisebenzi eyahlukeneyo yokutya, i-cardiovascular, yokuphefumula kunye nezinye iinkqubo zomzimba. Okwangoku iimbini zeeproductions ze-cannabinoid ziyakwaziwa, i-CB1 kunye ne-CB2, eyabandakanyeka kakhulu kwimisebenzi yenkqubo ye-nervous central kunye neyokugqibela kwimisebenzi yamasosha omzimba kunye nakwii-stem ze-system circulatory system.
Kulo pho nonongo, abaphandi bafumana i-30 engapheliyo yokutshaya i-cannabis yosuku oluye lwabekwa iliso kwiziko elinesibini elivaliweyo. Izifundo zazingumfanekiso usebenzisa i-postitron emission tomography (PET), enika ulwazi malunga neenkqubo zomzimba emzimbeni. Izifundo zazifakwe nge-radioligand, i-18F-FMPEP-d2, edibanisa i-isotope ye-fluorine ne-neurotransmitter analog ehlangene ne-CB1 i-receptors yengqondo.
Iziphumo zesifundo zibonisa ukuba inani le-receptor lancitshiswe malunga neepesenti ze-20 kwiibhokhwe ze-smokenabis xa ziqhathaniswa nezifundo zokulawula impilo enokungabikho kwinqanaba le-cannabisi ngexesha lokuphila kwabo. Ezi zinguqu zifunyenwe ukuba zilungelelaniswe nenani leemfundo ezidlulileyo. Kwi-30 i-smokenabis yokutshaya i-14, i-1 yezifundo zafundwa kwe-PET yesibini emva kwenyanga yokuziyeka. Kukho ukunyuka okuphawulekayo kwintsebenzo ye-receptor kule mimandla eyayisele iyancipha ekuqaleni kweso sifundo, isibonakaliso sokuba ngelixa i-cannabis engapheliyo yokubhema ibangela ukuhlaselwa kwe-CBXNUMX receptors, umonakalo uguquke ngokuziyeka.
Iinkcukacha ezithe zafunyanwa kule nkqubo kunye nezifundo ezizayo ziyakunceda abanye uphando oluhlola inxaxheba ye-PET imaging ye-receptors ye-CB1-kungekhona nje ukusetyenziswa kwezidakamizwa, kodwa kunye neentlobo zezifo zabantu, kubandakanya izifo zesifo kunye nomhlaza.
Ulwazi oluthe kratya: IPhepha lezeNzululwazi le-10: J. Hirvonen, R. Goodwin, C. Li1, G. Terry, S. Zoghbi, C Morse, V. Pike, N. Volkow, M. Huestis, R. Innis, iZiko leSizwe leNgqondo Ezempilo, iBethesda, MD; Iziko leLizwe leSizwe ngokuSetyenziswa gwenxa kweziyobisi, iBaltimore, MD; "Ukubuyela umva nokukhetha ubume bengingqi kwi-CB1 receptors kwi-CB58 kwii-cannabis ezingatshaywayo zemihla ngemihla," Intlanganiso yoNyaka yama-4 ye-SNM, kaJuni 8-2011, XNUMX, eSan Antonio, TX.
Ukubonelelwa nguMbutho weNyukliya
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